DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tam and polg

DIOPT Version :9

Sequence 1:	NP_476821.1	Gene:	tam / 34792	FlyBaseID:	FBgn0004406	Length:	1145	Species:	Drosophila melanogaster
Sequence 2:	XP_001921130.3	Gene:	polg / 100150924	ZFINID:	ZDB-GENE-060303-1	Length:	1206	Species:	Danio rerio

Alignment Length:	1231	Identity:	531/1231 - (43%)
Similarity:	703/1231 - (57%)	Gaps:	176/1231 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SSSVKIFRRVKPPQKVNKPKKPENVENGPTEYAENLVKVQMISRNLHAQLFPQAPRSISEQQVAS 84
            |:|||           :||      :.|..:...|.:.:||:||||..|:|....:..:::.|..
Zfish    24 STSVK-----------SKP------QQGSDQTRLNPLNIQMLSRNLQEQIFRGQTQEYTDEDVER 71

  Fly    85 AKVYKDELRRHGVDIESSAPVSDVQLKLPALRGANIEEHFHNIAKEQVQPYEELLLPLVQCEQLP 149
            :..:   |..||:..:.::.:.||||:||.:.|:||:|||..:|::|..||.|....| |..|:|
Zfish    72 SIRH---LEHHGLWGKETSLLPDVQLRLPEMYGSNIDEHFRLLAQKQSLPYLEAASQL-QKAQIP 132

  Fly   150 KRPKRWAFHTGWTAYDPEDGTATPVDHPLEKGLVFDVEVCVSEGQAPVLATAVSTKRWYSWVSSK 214
            :.|:.||:..|||.|. .||.:..|:.|.|..||||||||::||..|.||.|:|...||||.|.:
Zfish   133 EMPQEWAWEVGWTRYG-ADGESQKVNFPDENALVFDVEVCMAEGHCPTLAVALSPTAWYSWCSHR 196

  Fly   215 LTKHR------LSVEKLEPLDVDTDSERPHYTTDELIPLGTTGPGLVVGHNVSYDRARLKEQYLT 273
            |.:.|      ||:..|.||:...:|.:|..        |.....||||||||:|||.:|||||.
Zfish   197 LVEDRYAWSSDLSLADLIPLETLANSSQPRG--------GEWKERLVVGHNVSFDRAHIKEQYLL 253

  Fly   274 EDTGTRFVDTMSLHMCVSGVTSYQRAM-----------LKSKKE--------PAAEDLG---WLE 316
            :.:..||:|||||||.:||:|.:||::           |:..||        |....:|   |:.
Zfish   254 KGSKMRFLDTMSLHMAISGLTGFQRSLWMASKYGKRKGLQEVKEHMKRLGRRPEGPKIGSWEWVN 318

  Fly   317 QSSLNSLVEVHRLYCGGDTLSKEPRNIFVEGTLEQVRQSFQSLTNYCASDVEATHRILRVLYPLY 381
            .||:|:|.:||.||.|||.|.||.|.:||:|::..:|.:||.|..|||.||.||..:.....||:
Zfish   319 ISSINNLADVHALYVGGDPLMKESRELFVKGSMSDIRGNFQELMQYCALDVLATQEVFTQQLPLF 383

  Fly   382 AERFPHPASLAGMLEMGSAYLPVNSNWERYIREAQLTYEDLSIEAKYHLGRRAEEACSLLLDDQY 446
            .||.|||.:||||||||..|||||.||.||:.:||.|||:|..|.|..|...|::||.||.||:|
Zfish   384 MERCPHPVTLAGMLEMGVCYLPVNHNWRRYLEDAQATYEELQREMKKSLMILADDACQLLQDDRY 448

  Fly   447 RQNLWLWDEDWSVQELKLKQPP--KRK----------------------PLPTVELKDSGNTPEE 487
            :.:.||||.||.|||.|.|:.|  |:|                      |.|.:| ::.|::...
Zfish   449 KDDPWLWDLDWDVQEFKQKKVPVSKKKAKQEAEATEAANDSEAIDWPEDPGPPLE-EEEGDSDPR 512

  Fly   488 RRLQAKFQHLYDQQALLPARRPLLPGYPLWYRKLCRKPPAKRADEILEDDEEPWSPGASEISTGM 552
            |.|   .|.|.:..:.||.||..||.:|.||||||.|          ..:.|.||||||.||..|
Zfish   513 REL---LQRLKETVSCLPKRRQHLPAHPSWYRKLCVK----------MSEAEDWSPGASLISLQM 564

  Fly   553 QIAPKLLSLCWEGYPLHYEREQGWGFLVPFRSDSEGVDRLPMEQLLAHCPVPEFARLSASKAE-- 615
            :|.|||:.|.|:|:||||..:.|||:|||.|.|:..:.....|.:   ||......:.....|
Zfish   565 RITPKLMGLTWDGFPLHYTDQHGWGYLVPGRRDNLDISEDNEEPV---CPYRAIESVYKEYCEQK 626

  Fly   616 ------------SD--MAFDMLPGQVEQHLGKREHY-----------KKLSQKQQRL------ET 649
                        ||  |..|....|..:.:.:.|.:           |::::|...:      |.
Zfish   627 GKEQPKYPDSPVSDELMLTDTAVWQTVEEVSRLEMFDDEALSTAAPSKRITKKVNSVFKSLNGEC 691

  Fly   650 QY-QGSGVWCNKVLDDCCFFLKLPHKNGPSFRVGNPLSKDFLNKFAENVLSSGDPSCQAAARVID 713
            .| .|:|.: |.|....|:|.|||||:|....||:|.|||||:|.....|.:|..... |.|.::
Zfish   692 PYHHGNGPY-NDVNIPGCWFFKLPHKDGNENNVGSPFSKDFLSKMESGTLQAGREGTN-ATRALE 754

  Fly   714 IARMMSYWRNNRDRIMGQMVVWLDSQQLP-----NEFTGEKCQPIAYGAICPQVVACGTLTRRAM 773
            |.:|:|:|||.:.||..||||||...:||     ::...|:.|   ||||.|||:..||:||||:
Zfish   755 INKMISFWRNAQKRISSQMVVWLRRAELPRSVRLHQDYDEEGQ---YGAILPQVIPAGTVTRRAV 816

  Fly   774 EPTWMTASNSRPDRLGSELRSMVQAPPGYRLVGADVDSQELWIASVLGDAYACGEHGATPLGWMT 838
            ||||:||||:|.||:||||::|||.||.|.||||||||||||||::||:|:..|.||.|..||||
Zfish   817 EPTWLTASNARKDRVGSELKAMVQVPPAYHLVGADVDSQELWIAAMLGEAHFAGMHGCTAFGWMT 881

  Fly   839 LSGSKSNGSDMHSITAKAVGISRDHAKVINYARIYGAGQLFAETLLRQFNPTFSASEAKAKAMKM 903
            |.|.||.|:|:||.||.||||||:||||.||.|||||||.|||.||.|||...|..||..||.:|
Zfish   882 LQGKKSQGTDLHSRTADAVGISREHAKVFNYGRIYGAGQPFAERLLMQFNHRLSQQEAAGKARQM 946

  Fly   904 FSITKGKRVYRLREEFH----------DELEDRAYSSYE---ASRLAIQR---------NRTLAE 946
            :::|||.|.|.|.||..          :..||.:.|..:   .|::|.|.         |.|...
Zfish   947 YALTKGLRRYHLSEEGEWLLQKLNVNVERAEDGSISLQDLRKISKVATQSTTRGSKKKWNLTAGR 1011

  Fly   947 VFHRPNWQGGTESAMFNRLEEIATGSQPRTPFLGGRLSRALEADTGPEQEQRFLPTRINWVVQSG 1011
            |     |..||||.|||:||.||...:|.||.|..|:|||||.....|:   |:.:|:||||||.
Zfish  1012 V-----WTDGTESYMFNKLESIAQSDRPATPVLNCRISRALEPSAVQEE---FITSRVNWVVQSS 1068

  Fly  1012 AVDFLHLMLVSMRWLMGSH---VRFCLSFHDELRYLVKEELSPKAALAMHITNLMTRSFCVSRIG 1073
            |||:|||||||||||...|   .|||:|.|||:||||..|...:||||:.||||:||.....::|
Zfish  1069 AVDYLHLMLVSMRWLFEEHDIDGRFCISIHDEVRYLVTSEDRYRAALALQITNLLTRCMFAFKLG 1133

  Fly  1074 LQDLPMSVAFFSSVEVDTVLRKECTMDCKTPSNPHGLRIGYGIQPGQSLSVAEAIEKAGGN 1134
            :.|||.||||||:|::|..||||.||||||||:|.|:...||:..|::|.:.:.||...|:
Zfish  1134 MMDLPQSVAFFSAVDIDKCLRKEVTMDCKTPSSPAGVERRYGLPQGEALDIYQIIEITKGS 1194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tam	NP_476821.1	DNA_pol_A	398..>440	CDD:295402	22/41 (54%)
		TRH	<420..539	CDD:283171	49/142 (35%)
		DNA_pol_gammaA	705..1107	CDD:176478	231/431 (54%)
polg	XP_001921130.3	DnaQ_like_exo	<230..>266	CDD:299142	21/35 (60%)
		DNA_pol_A	400..>442	CDD:295402	22/41 (54%)
		eIF3_subunit	445..>521	CDD:285763	25/79 (32%)
		DNA_pol_gammaA	741..1167	CDD:176478	232/437 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592254
Domainoid	1	1.000	401	1.000	Domainoid score	I698
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2016
Inparanoid	1	1.050	879	1.000	Inparanoid score	I383
OMA	1	1.010	-	-		QHG52013
OrthoDB	1	1.010	-	-		D192641at33208
OrthoFinder	1	1.000	-	-		FOG0004939
OrthoInspector	1	1.000	-	-		oto40561
orthoMCL	1	0.900	-	-		OOG6_104329
Panther	1	1.100	-	-	LDO	PTHR10267
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3481
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810