DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment b and gad1b

DIOPT Version :9

Sequence 1:	NP_001246025.1	Gene:	b / 34791	FlyBaseID:	FBgn0000153	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_919400.1	Gene:	gad1b / 378441	ZFINID:	ZDB-GENE-030909-3	Length:	587	Species:	Danio rerio

Alignment Length:	590	Identity:	255/590 - (43%)
Similarity:	376/590 - (63%)	Gaps:	44/590 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 STTSGDDLASVSPLTATAALVASTSSPADSTSTVA--------------------FEQASKMLAN 65
            |:::||    :.|.||.....|:||   |:...||                    .::.|:|:.:
Zfish     7 SSSAGD----MDPNTANLRQPATTS---DAWYGVAHGCTRKLGMKICGFLQKNNSLDEKSRMVGS 64

  Fly    66 ---AANNNNNNNNNITSTKD--DLSSFVASH--PAAEFE----GFIRACVDEIIKLAVFQGTNRS 119
               :|.|..:.:||...|:|  |.|:..|..  ||...|    .|:...| ||:...|.:..:||
Zfish    65 FKESAKNQMSCDNNERFTRDETDFSNLFARDLLPAKNGEEPTIQFLLEVV-EILTNYVRKTFDRS 128

  Fly   120 SKVVEWHEPAEL---RQLFDFQLREQGESQDKLRELLRETIRFSVKTGHPYFINQLYSGVDPYAL 181
            :||:::|.|.:|   .:.|:.:|.:|.||.:::....|:|:::.|:||||.|.|||.||:|...|
Zfish   129 TKVLDFHHPHQLLEGMEGFNLELSDQPESLEQILVDCRDTLKYGVRTGHPRFFNQLSSGLDIIGL 193

  Fly   182 VGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPNGGQGDGIFCPGGSIANGYAISCAR 246
            .|:|||...|.:::|||:||:|.|||:..|.:||.|:|:|| |.||.:|.|||:|:|.|::..||
Zfish   194 AGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIIGWPN-GDGDALFSPGGAISNMYSVMVAR 257

  Fly   247 YRHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMGFGSDHVRKIATNEVGKMRLSDLEKQVK 311
            |::.||.|..|:..|..|::||||.:|||::|....:|||.::|..:.|:|.|::..:|||.:|.
Zfish   258 YKYFPEVKTKGMSAAPRLVLFTSEHSHYSIKKAGAVLGFGKENVILLKTDERGRVIPADLEAKVI 322

  Fly   312 LCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKYRHLLNGIE 376
            ...:.|:.||.|:|||||||.||||.:..|:::|:|||:|:|||.|||||.|||:|:||.|:|||
Zfish   323 DAKQKGYVPLFVNATAGTTVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMSRKHRHKLSGIE 387

  Fly   377 RADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYDTSFDTGDKHIQCGRRA 441
            ||:||||||||::....|||..|.|.:.:|..|:|..|.||||.||.||.::|||||.|||||..
Zfish   388 RANSVTWNPHKMMGVPLQCSAILVREKGILQGCNSMCAGYLFQPDKQYDVTYDTGDKAIQCGRHV 452

  Fly   442 DVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLE-SPECTNISFWYVPPGLRE 505
            |:||||.|||||||.|.|.|:::...::|:...|::.|.|:|:|.| .|:.||:.|||:||.||.
Zfish   453 DIFKFWLMWKAKGTIGFEQHIDRCLELSEYLYNKIKNREGYEMVFEGQPQHTNVCFWYIPPSLRG 517

  Fly   506 MERNREFYDRLHKVAPKVKEGMIKKGSMMITYQPLRQLPNFFRLVLQNSCLEESDMVYFLDEIES 570
            |....|..::||:||||:|..|::.|:.|:.|||.....||||:|:.|..:.:||:.:.:||||.
Zfish   518 MPNGDERREKLHRVAPKIKAMMMECGTTMVGYQPQGDKVNFFRMVVSNHAVTKSDIDFLIDEIER 582

  Fly   571 LAQNL 575
            |.|:|
Zfish   583 LGQDL 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
b	NP_001246025.1	AAT_I	128..499	CDD:302748	184/374 (49%)
gad1b	NP_919400.1	Pyridoxal_deC	137..511	CDD:278699	184/374 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020