Protein Alignment b and HDC

DIOPT Version :9

• Sequence 1: NP_001246025.1
• Gene: b / 34791
• FlyBaseID: FBgn0000153
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_016877583.1
• Gene: HDC / 3067
• HGNCID: 4855
• Length: 697
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 132/538 - (24%)
• Similarity: 217/538 - (40%)
• Gaps: 112/538 - (20%)

  Fly   101 RACVDEIIKLAVFQGTNRSSKVVEWHEPAELRQLFDFQLREQGESQDKL-----RELLRETIRFS 160
            |..||.|.:   :..|.|..:|....:|..||........|..:|.|.:     |.::...:.:.
Human    12 REMVDYICQ---YLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVVHWQ 73

  Fly   161 VKTGHPYFINQLYSGVDPY-ALVGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPN-- 222
            ....|.|     |..:..: :|:|..|.||:|...:|:..:|..|.:|..|:..:.:::|.|.
Human    74 SPHMHAY-----YPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHF 133

  Fly   223 -----GGQGDGIFCPGGSIANGYAISCARYRHSPESKKN------GLFNAKPLIIFTSEDAHYSV 276
                 ..||.|:.....|.:...|:..||.....|.|.:      ...||: |:.:.|:.||.||
Human   134 LHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNAR-LVAYASDQAHSSV 197

  Fly   277 EKLAMF----MGFGSDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDD 337
            ||..:.    |.|       :..::...:|...|:|.::...:.|..|:.|.||.|||.:.|||.
Human   198 EKAGLISLVKMKF-------LPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDC 255

  Fly   338 LAGISEVCKKYN-----------------------------------MWMHVDAAWGGGALMSKK 367
            |:.:..:.|.::                                   :|:|:|||:.|.|.:..:
Human   256 LSELGPISKAHHPCSPPLSLARCETSFPTSYLPSGQVMFASSGAREGLWLHIDAAYAGTAFLCPE 320

  Fly   368 YRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYDTSFDTGD 432
            :|..|.|||.|||.|:||.|.:.....|:.|..:.:..|.|..|.|..||...:....|.|
Human   321 FRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDF---- 381

  Fly   433 KH--IQCGRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELV---------- 485
            .|  |...||....|.||:.::.|.:.|:|||.....||::|.:.||..|.||:.
Human   382 MHWQIPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVF 446

  Fly   486 -LESPEC--TNISFWYVPPGLREMERNREFYDRLHKVAPKVKEGMIKK---GSMMITYQPLRQLP 544
             |:.|.|  .|:        |:|:.:    ..||..:...:::.:|.:   .|...|...:.:..
Human   447 RLKGPNCLTENV--------LKEIAK----AGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDW 499

  Fly   545 NFFR----LVLQNSCLEE 558
            |..|    |:|...|..:
Human   500 NLIRDAATLILSQHCTSQ 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
b	NP_001246025.1	AAT_I	128..499	CDD:302748	113/443 (26%)
HDC	XP_016877583.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900