DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment b and Csad

DIOPT Version :9

Sequence 1:	NP_001246025.1	Gene:	b / 34791	FlyBaseID:	FBgn0000153	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001346055.1	Gene:	Csad / 246277	MGIID:	2180098	Length:	493	Species:	Mus musculus

Alignment Length:	473	Identity:	246/473 - (52%)
Similarity:	339/473 - (71%)	Gaps:	9/473 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 VDEIIKLAVFQGTNRSSKVVEWHEPAELRQLFDFQLREQGESQDKLRELLRETIRFSVKTGHPYF 168
            |||    |:.:||:.|.||.||.||.||:||.|.:|:.||||::::.|..|..|.:|||||||.|
Mouse    29 VDE----AILKGTSASEKVCEWKEPEELKQLLDLELQSQGESREQILERCRTVIHYSVKTGHPRF 89

  Fly   169 INQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPNGGQGDGIFCPG 233
            .|||:||:||:||.|:.:|::||.|.||||:||:|.||||:||.::|.:||:   ..|||:||||
Mouse    90 FNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLKKLRALVGW---NSGDGVFCPG 151

  Fly   234 GSIANGYAISCARYRHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMGFGSDHVRKIATNEV 298
            |||:|.||::.||::..|:.|:.||....||.:|||::.|||:.|.|.|:|.|:|.||.:..:|.
Mouse   152 GSISNMYAMNLARFQRYPDCKQRGLRALPPLALFTSKECHYSITKGAAFLGLGTDSVRVVKADER 216

  Fly   299 GKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGAL 363
            |:|...|||:|:.|....|..|.:||||:|||||||||.|..|::||:::.:|.||||||||..|
Mouse   217 GRMIPEDLERQIILAEAEGSVPFLVSATSGTTVLGAFDPLDAIADVCQRHGLWFHVDAAWGGSVL 281

  Fly   364 MSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRH-QQVLAQCHSTNATYLFQKDKFYDTS 427
            :|:.:||||:||:|||||.|||||||||..|||..|.|. ..:|.:||.:.|:||||:|||||.:
Mouse   282 LSRTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLRDTSNLLKRCHGSQASYLFQQDKFYDVA 346

  Fly   428 FDTGDKHIQCGRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLESPECT 492
            .|||||.:|||||.|..|.|.||||:|.||||..:::.|.:..:...::::|.|||||:| ||..
Mouse   347 LDTGDKVVQCGRRVDCLKLWLMWKAQGGQGLERRIDQAFALTRYLVEEIKKREGFELVME-PEFV 410

  Fly   493 NISFWYVPPGLREMERNREFYDRLHKVAPKVKEGMIKKGSMMITYQPLRQLPNFFRLVLQNSCLE 557
            |:.||:|||.||..:.:.::..||.:|||.:||.|:|||:|||.|||.....||||:|:.|..|.
Mouse   411 NVCFWFVPPSLRGKKESPDYSQRLSQVAPVLKERMVKKGTMMIGYQPHGTRANFFRMVVANPILA 475

  Fly   558 ESDMVYFLDEIESLAQNL 575
            ::|:.:.|.|:|.|.|:|
Mouse   476 QADIDFLLGELELLGQDL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
b	NP_001246025.1	AAT_I	128..499	CDD:302748	198/371 (53%)
Csad	NP_001346055.1	DOPA_deC_like	89..481	CDD:99743	207/395 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850747
Domainoid	1	1.000	426	1.000	Domainoid score	I611
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1283
Isobase	1	0.950	-	0.918296	Normalized mean entropy	S2959
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	1	1.000	-	-		otm44124
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45677
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5043
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.940