DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment b and gad1a

DIOPT Version :9

Sequence 1:	NP_001246025.1	Gene:	b / 34791	FlyBaseID:	FBgn0000153	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_002663350.1	Gene:	gad1a / 100329827	ZFINID:	ZDB-GENE-070912-472	Length:	591	Species:	Danio rerio

Alignment Length:	515	Identity:	234/515 - (45%)
Similarity:	351/515 - (68%)	Gaps:	10/515 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 NNNNNNNITSTKDDLSSFVASH--PAAEFEGFIRACVDEIIKLA---VFQGTNRSSKVVEWHEPA 129
            :|..::....|:.|.|:..|..  ||...|.:....:.|::::.   |.:..:||:||:::|.|.
Zfish    78 DNERDSRFRRTETDFSNLYARDLLPAKNGEEYTMQFLLEVVEILTNYVRKTFDRSTKVLDFHHPH 142

  Fly   130 EL---RQLFDFQLREQGESQDKLRELLRETIRFSVKTGHPYFINQLYSGVDPYALVGQWLTDALN 191
            :|   .:.|:.:|.:|.||.:::....|:|:::.|:||||.|.|||.||:|...|.|:|||...|
Zfish   143 QLLEGMEGFNLELCDQPESLEQILVDCRDTLKYGVRTGHPRFFNQLSSGLDIIGLAGEWLTSTAN 207

  Fly   192 PSVYTYEVAPLFTLMEEQVLAEMRRIVGFPNGGQGDGIFCPGGSIANGYAISCARYRHSPESKKN 256
            .:::|||:||:|.|||:..|.:||.|||:|| |:|||||.|||:|:|.|::..|||:|.||.|..
Zfish   208 TNMFTYEIAPVFVLMEQLTLKKMREIVGWPN-GEGDGIFSPGGAISNMYSVMVARYKHYPEIKIK 271

  Fly   257 GLFNAKPLIIFTSEDAHYSVEKLAMFMGFGSDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPL 321
            |:..|..|::||||.:|||::|.:..:|||::::..:.|:|.|::..:|||.:|....:.|:.|:
Zfish   272 GMAAAPRLVLFTSEHSHYSIKKASAVLGFGTENLILLRTDERGRVIPADLEAKVIDAKQKGFVPM 336

  Fly   322 MVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPH 386
            .|:||||:||.||||.:..|:::|:|||||:|||.|||||.|||:|::|.|:|||||:|||||||
Zfish   337 FVNATAGSTVYGAFDPINEIADICEKYNMWLHVDGAWGGGLLMSRKHKHKLSGIERANSVTWNPH 401

  Fly   387 KLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYDTSFDTGDKHIQCGRRADVFKFWFMWK 451
            |::....|||..|.|.:.:|..|:|..|.||||.||.||.::|||||.|||||..|:||||.|||
Zfish   402 KMMGVPLQCSAILVREKGLLQGCNSMCAGYLFQPDKQYDVTYDTGDKAIQCGRHVDIFKFWLMWK 466

  Fly   452 AKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLE-SPECTNISFWYVPPGLREMERNREFYDR 515
            :|||.|.|.|:::...::|:...|::.|.|:|:|.: .|:.||:.|||:||.||.:....|...|
Zfish   467 SKGTTGFEKHIDRCLELSEYLYHKIKNREGYEMVFQGEPQHTNVCFWYIPPSLRLLPDGEEKRHR 531

  Fly   516 LHKVAPKVKEGMIKKGSMMITYQPLRQLPNFFRLVLQNSCLEESDMVYFLDEIESLAQNL 575
            |||||||:|..|::.|:.|:.|||..:..||||:|:.|..:..||:.:.:||||.|.|:|
Zfish   532 LHKVAPKIKALMMECGTTMVGYQPQGEKVNFFRMVVSNPAVTRSDIDFLIDEIERLGQDL 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
b	NP_001246025.1	AAT_I	128..499	CDD:302748	183/374 (49%)
gad1a	XP_002663350.1	Pyridoxal_deC	141..515	CDD:278699	183/374 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020