DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment b and gad3

DIOPT Version :9

Sequence 1:	NP_001246025.1	Gene:	b / 34791	FlyBaseID:	FBgn0000153	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001083039.2	Gene:	gad3 / 100038790	ZFINID:	ZDB-GENE-070424-80	Length:	546	Species:	Danio rerio

Alignment Length:	553	Identity:	230/553 - (41%)
Similarity:	331/553 - (59%)	Gaps:	29/553 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 TSSPADSTSTVAFEQASKMLANAANNNNNNNNNITSTKDDLS--------SFVASH-----PAAE 95
            |.||   .|.:.|.||.:   ...:.:..:.:::.:|.|.|.        .|...|     ||.:
Zfish     2 TRSP---ESIMDFTQADR---RHLDKSKQDTSSLENTDDGLKYDSGRVTHDFSCIHSKDLLPAED 60

  Fly    96 FEGFIRACVDEIIKLA---VFQGTNRSSKVVEWHEPAELRQ-LFDFQLREQGESQDKLRELL--- 153
            .|...:..:.|::.:.   :.:...||:||:::|.|.:|.: |..|.| |..:..|.|.:||
Zfish    61 GEEATKHFLQELVNILLAYISKSLKRSTKVLDFHYPHQLNEGLEGFSL-ELPDQPDNLEQLLVDC 124

  Fly   154 RETIRFSVKTGHPYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIV 218
            |:|:::.||||||.|.|||.:|:|...|.|:|||...|.:::|||::|:|.||||.||.:|..|:
Zfish   125 RDTLKYGVKTGHPRFFNQLSTGLDIVGLAGEWLTSTANTNMFTYEISPVFILMEEVVLRKMHTII 189

  Fly   219 GFPNGGQGDGIFCPGGSIANGYAISCARYRHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAMFM 283
            |:|. ..||||||||||::|.|::..||:...|..|.:|:.....|.:|||..:|||::|.|..:
Zfish   190 GWPE-EDGDGIFCPGGSMSNLYSVLLARFHLFPAVKTHGMCAIPRLAMFTSAHSHYSIKKSAAVL 253

  Fly   284 GFGSDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKY 348
            |.|:::|..:..:|.|||..|:|...::.....|..|..|:|||||||.||||.|..|:::|:.:
Zfish   254 GIGTENVIVVRCDERGKMISSELNSSIEEAKSKGLVPFYVNATAGTTVYGAFDPLHKIADICEHH 318

  Fly   349 NMWMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTN 413
            .:|||||||||||.|:|.|:|..|:|||||.||||||||::....||||.|.:.:.:|.||:...
Zfish   319 GLWMHVDAAWGGGLLLSNKHRVKLHGIERAHSVTWNPHKMMGVPLQCSTILVKRKGLLQQCNQLC 383

  Fly   414 ATYLFQKDKFYDTSFDTGDKHIQCGRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRE 478
            |.||||.||.|:.|:|||||.|||||..|:||.|.||||||::|.|:.|......||:...|::.
Zfish   384 AEYLFQPDKHYEVSYDTGDKSIQCGRHVDIFKLWLMWKAKGSEGFESQVNHCLENAEYLYYKLKR 448

  Fly   479 RPGFELVLE-SPECTNISFWYVPPGLREMERNREFYDRLHKVAPKVKEGMIKKGSMMITYQPLRQ 542
            |..|:||.: .||.:|:.|||:|..::.:....|....||.||||:|..|:::|..||.||||..
Zfish   449 RTDFQLVFKGKPEHSNVCFWYLPKRVQNIPLGPEREKELHMVAPKIKTKMMEEGFTMIGYQPLED 513

  Fly   543 LPNFFRLVLQNSCLEESDMVYFLDEIESLAQNL 575
            ..||||.|..|...:..|:.:.||||..|...|
Zfish   514 KVNFFRCVFSNPATQREDVDFLLDEIVRLGCEL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
b	NP_001246025.1	AAT_I	128..499	CDD:302748	178/375 (47%)
gad3	NP_001083039.2	Pyridoxal_deC	96..469	CDD:278699	177/374 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920