DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sos and BUD5

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_009967.2	Gene:	BUD5 / 850405	SGDID:	S000000634	Length:	642	Species:	Saccharomyces cerevisiae

Alignment Length:	795	Identity:	153/795 - (19%)
Similarity:	271/795 - (34%)	Gaps:	269/795 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 PKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEK----VMASLSKERQV 444
            ||...|.||..::|..:.|..|..:.|.|..:.|..:..:|..|   ||:    |.|..:.:.|:
Yeast     3 PKNKYVYICVEYIYIYFAKIHKQSTLSSDTTKMFVLIDNVLAYL---LEQDDLFVTARFAIQGQI 64

  Fly   445 PVSGRVRRQLAIERTRE--LQMKVEH---WEDKDVGQNCNEFI---------------REDSLSK 489
             ||.||.: :.|....:  ||..:.|   :.|..|.:...:.:               ||..|.|
Yeast    65 -VSRRVNK-IHISNITDVLLQQFISHTLPYNDNIVPKKILDSMRTAVRQLLEATACVSRECPLVK 127

  Fly   490 LGSGKRIWSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRV--DIND------- 545
              ..:.|...||..|.|.                      |||.....|..|  .:|.
Yeast   128 --RSQDIKRARKRLLSDW----------------------YRLGADANMDAVLLVVNSAWRFLAV 168

  Fly   546 -RPDSDDLKNSF-ELAPRMQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIER--- 605
             ||..:.::::. ||...:...::....|.|..   .|.:.:|:.:..|...:|.:||::.|
Yeast   169 WRPFVNSIQHATQELYQNIAHYLLHGNVNIQRV---TALIQLVMGQDDLLFSMDDVLQEVFRIQL 230

  Fly   606 ---------KHPLRMPSPEIYKFAVPDSGDNIVLEERESAGVPMIKGATLCKLIERLTYHIYADP 661
                     .|..:.|||.       ||. |::|..|:..    ...|.|.:|:  |:|     |
Yeast   231 YLNKMLPHNSHKWQKPSPF-------DSA-NLLLNFRDWT----TDNALLQELL--LSY-----P 276

  Fly   662 TFVRTFLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWK 726
            |..:.....:    |..:|:|:.||.:        :||:.|.
Yeast   277 TINKNKHKNH----SVPRLIQIWVESY--------WQDSETT----------------------- 306

  Fly   727 RYRKEYVQPVQFRVLNVLRHWVDH--HFYDFEKDPMLLEKLLNFLEHVNGKSMRKWVDSVLKIVQ 789
                         :.::|..|..|  .:|::::   |...::...  :|.|..|:.....:.:..
Yeast   307 -------------LKDILNFWYSHLAEYYEYQE---LFADIVQLF--INKKRTRQLKIHYIGLTD 353

  Fly   790 RKNEQEKSNKKIVYAYGHDPPPIEHH---------LSVPNDEIT--------------------- 824
            ::.|:.|             ||:::.         .:..|||:.
Yeast   354 KEIEENK-------------PPLDYENLFLQYEIDKTNANDELCGATDLSDLLFQWKQGELLEVE 405

  Fly   825 --LLTLHPLELARQLTLLEFEMYKNVKPSEL----------VGSPWTKKDKEVKSPNLLKIMKHT 877
              .|.:.|..||:.|||||..:|.:::..|.          :.|.:|..: ::.|..|...::.|
Yeast   406 AFALNVSPWSLAKTLTLLESSLYLDIETIEFTRHFKHNDTTIDSVFTLSN-QLSSYVLETTLQQT 469

  Fly   878 TNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGL 942
            ..::.|                     ::|.:..|.|.|.|.:.||:.::...|:.||     .|
Yeast   470 HTISYW---------------------LQVALSCLYLRNLNSLASIITSLQNHSIERL-----SL 508

  Fly   943 PERYRKFLEECRELSDDHL--------------KKYQERLRSI---NPPCVPFFGRYLTNILHLE 990
            |          .::..|||              ..|:..::.|   ..|||||....:.:|..:.
Yeast   509 P----------IDVKSDHLFQRLKVVVHPNNNYNVYRRTIKHIFHSQLPCVPFTSLLIRDITFIR 563

  Fly   991 EGNPDLLANTELINFSKRRKVAEIIGEIQQYQNQPY----CLNEESTIRQFFEQLDPFNGLSDKQ 1051
            :||.....:...:|..|..::.:|:...|..|.:.|    |.|  :|.|.....:...:.|.:..
Yeast   564 DGNDTFTKDGNNVNMQKFNQITKIVAFAQYLQQKQYEDIHCSN--TTARSLLGAMIKVHTLYNDN 626

  Fly  1052 MSDYLYNESLRIEPR 1066
             .|..|..|:...||
Yeast   627 -KDRAYQVSIAKVPR 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091	13/47 (28%)
		PH_SOS	476..586	CDD:269963	22/135 (16%)
		PH	482..587	CDD:278594	22/130 (17%)
		RasGEFN	637..791	CDD:214571	23/155 (15%)
		RasGEF	825..1062	CDD:238087	56/267 (21%)
BUD5	NP_009967.2	RasGEFN	230..339	CDD:214571	30/180 (17%)
BUD5	NP_009967.2	RasGEF	409..640	CDD:214539	56/270 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910