DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sos and LOC797658

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	XP_009301929.2	Gene:	LOC797658 / 797658	-ID:	-	Length:	598	Species:	Danio rerio

Alignment Length:	519	Identity:	96/519 - (18%)
Similarity:	191/519 - (36%)	Gaps:	125/519 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   660 DPTFVRTFLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHRED 724
            ||:|||.||..:.::.|...|.:.|:         |..|:            |.|.|
Zfish    30 DPSFVRMFLMMHPWYISSTDLSKKLL---------LKSQE------------GSDDE-------- 65

  Fly   725 WKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLEKLLNFLEHVN--------------GK 775
                       ::.::.::::.|:.....:|:.:|.|.:::.:..:::|              ..
Zfish    66 -----------LRAKICHLVKFWISEFPAEFDLNPALADQIKDLRDNLNTGGNETPSQLIDVESV 119

  Fly   776 SMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLL 840
            ...||...|.|.|...:::    :|:...:.|                    |.|.|||..||.|
Zfish   120 PSYKWKRQVTKRVPSMSKR----RKMSLLFDH--------------------LDPYELAEHLTYL 160

  Fly   841 EFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAI 905
            |::.:..:...:.  ..:......|.:|.|.:.:....:|::||:..:.......:|.|::...|
Zfish   161 EYKSFCKILFQDY--HSFVMHGCTVDNPILERFITLFNSVSQWIQLMVLSKPTAPQRAAVIAHFI 223

  Fly   906 EVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECREL--SDDHLKKYQERL 968
            :|...:|:|.|||.::::|..:..:|:.||:.|...:.....|......::  |..:..:|:.|.
Zfish   224 QVAEKLLQLQNFNTLMAVVGGLSNSSISRLKETQANISSDTNKVFNSLLDMLTSSGNYSQYRRRF 288

  Fly   969 RSINPPCVPFFGRYLTNILHLEEGNPDLL-ANTELINFSKRRKVAEIIGEIQQYQ-NQPYCLNEE 1031
            ........|.....|.:::.:.....|.. |....:|.:|.:::..|:.|:...| |.|:.....
Zfish   289 AECTGFRFPILAVSLKDLIAVHVALSDWTDAQKTQVNLTKTQQLYAILQELSLVQSNPPHIEANT 353

  Fly  1032 STIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQT 1096
            ..:......||.::      ..:.:|..||:.|||..|                         ..
Zfish   354 DLLNLLTVSLDQYH------TEEEIYQLSLQREPRATK-------------------------PA 387

  Fly  1097 NSSSKLSNSTSSVA--AAAAASSTATSIATASAPSL---HASSIMDAPTAAAANAGSGTLAGEQ 1155
            |||     ||||.|  ..:.....|.|:...:.|::   |...::|:........|.|.::.|:
Zfish   388 NSS-----STSSPAPKKLSIIDDWAASVKPKADPAIISKHIEKMVDSVFKNFDTNGDGFISREE 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	25/144 (17%)
		RasGEF	825..1062	CDD:238087	48/240 (20%)
LOC797658	XP_009301929.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910