DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sos and Rasgef1a

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_001349032.1	Gene:	Rasgef1a / 70727	MGIID:	1917977	Length:	498	Species:	Mus musculus

Alignment Length:	507	Identity:	104/507 - (20%)
Similarity:	194/507 - (38%)	Gaps:	121/507 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   624 SGDNIVLEERESAGVPMIKGATLCKLIERL--TYHIYADPTFVRTFLTTYRYFCSPQQLL----Q 682
            |.|.|..:.|.::|       :|..|:|.|  |...|.|.|::.|||.:.|.|..|..||    |
Mouse    43 SKDLIFQDGRLTSG-------SLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQ 100

  Fly   683 LLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHW 747
            :.:|:          :....||.                       .|..::....:::.:|:.|
Mouse   101 ICLEQ----------RQQLEAGP-----------------------EKAKLKSFSTKIVQLLKEW 132

  Fly   748 VDHHFYDFEKDPMLLEKLLNFLEH----------------VNG---KSMRKWVDSVLKIVQRKNE 793
            .:...|||:.:.::.|  |..:.|                .||   |::.:.:.|:|..:..:::
Mouse   133 TEAFPYDFQDEKVMAE--LKAIAHRVTQCDEYLMQPRPSQENGTVKKAIAQMIQSLLLSLAARSQ 195

  Fly   794 QEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSEL--VGS 856
            .::..:|:........|.::........:|..:...||.||:|||.:|.|...:::|.:|  :.|
Mouse   196 LQELREKLRSPVVDKGPVLKAKPPAAQKDILGVCSDPLVLAQQLTHIELERVNSIRPEDLMQIIS 260

  Fly   857 PWTKKDKEVKSPNLLKI--------------MKHTTNVTRWIEKSITEAENYEERLAIMQRAIEV 907
            .....|......::.|.              |...|.|.|.::|        :.|..:::..|:|
Mouse   261 HMDSLDNHRCRGDMTKTFSLEAYDNWFNCLSMLVATEVCRVVKK--------KHRTRMLEFFIDV 317

  Fly   908 MMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECRELSDDH------LKKYQE 966
            ......:.|||.:::|::.|..:.|.||:.|:..:.......||...:.|.:.      |:...:
Mouse   318 ARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQ 382

  Fly   967 RLRSINPP----CVPFFGRYLTNILHLEEGNPDLLANTELINFSKRRKVAEIIGEIQQYQN---- 1023
            |.::.|..    .:|.|..::.:|..|.:.:.:.|.|.. |||.|..:::..|.|...:..
Mouse   383 RSQTANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGH-INFKKFWEISRQIHEFMTWTQVECP 446

  Fly  1024 -------QPYCL-----NEESTIRQFFEQLDPFNGL---SDKQMSDYLYNES 1060
                   |.|.|     :||:.....||...|.|.:   |.|.:...|.|.:
Mouse   447 FEKDKKIQSYVLTAPIYSEEALFIASFESEGPENHMEKDSWKALRTTLLNRA 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	35/178 (20%)
		RasGEF	825..1062	CDD:238087	62/281 (22%)
Rasgef1a	NP_001349032.1	REM	57..163	CDD:100121	29/140 (21%)
Rasgef1a	NP_001349032.1	RasGEF	235..427	CDD:306970	44/200 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910