DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sos and SOS2

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_008870.2	Gene:	SOS2 / 6655	HGNCID:	11188	Length:	1332	Species:	Homo sapiens

Alignment Length:	1390	Identity:	611/1390 - (43%)
Similarity:	840/1390 - (60%)	Gaps:	141/1390 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 YDFTKCENAARWRGLFTPSLKKVLEQVHPRVTAKEDALLYVEKLCLRLLAMLCAKPLPHSVQDVE 122
            |:|...||:.:||||...:|:||.|||||.::|.|::|.|:|:|..:||..||... |.:|||||
Human     8 YEFFSEENSPKWRGLLVSALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQ-PRTVQDVE 71

  Fly   123 EKVNKSFPAPIDQWALNEAKEVINSKKRKS--VLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVLE 185
            |:|.|:||.|||:||:.:|:..|..:||::  :||.:|:|..| |:||.||:|..||.::|||||
Human    72 ERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSL-KEVLGYKVDYHVSLYIVAVLE 135

  Fly   186 YISADILKMAGDYVIKIAHCEITKEDIEVVMNADRVLMDMLNQSEAHILPSPLSLPAQRASATYE 250
            ||||||||:||:||..|.|.||:::||:|.|.||:|||||.:|.:..::......|:......|.
Human   136 YISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYY 200

  Fly   251 ETVKELIHDEKQYQRDLHMIIRVFREELVKIVSD-----PRELEPIFSNIMDIYEVTVTLLGSLE 310
            :.|:..|.:|:||.|:|:|||:||||   ..:||     |.::|.|||||.||:|:||.|||.:|
Human   201 DLVRTEIAEERQYLRELNMIIKVFRE---AFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIE 262

  Fly   311 DVIEMSQEQSA-PCVGSCFEELAEAEEFDVYKKYAYDVTSQASRDALNNLLSKPG-ASSLTTAGH 373
            |.:||:.|.|. |..|||||:|||.:.||.|:..:.|:.|....:..|.|:::|. |....:...
Human   263 DTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIAD 327

  Fly   374 GFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMASL 438
            ||::||:|.||:|:|||:.|.:.||:.:|.||..|..|:|.|...|....|..|...::::....
Human   328 GFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQY 392

  Fly   439 SKERQV--PV----SGRVR-RQLAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSGKRI 496
            |..|:.  ||    |.::| :.|||::..|:|..::.||.||:||.|||||.|..|:::|:.
Human   393 SPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAK--- 454

  Fly   497 WSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSFELAPR 561
             .||.:|||||||:.||.| ..||...|.::.:||||||:.||::.|.|:.|:.:.|::|||..:
Human   455 -HERHIFLFDGLMISCKPN-HGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSK 517

  Fly   562 MQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAVPDSGD 626
            .:..|:..||:|:.|::|||.|:.:..:|.|||.|||:|...|.:.|||:||||:|:|.|.||.:
Human   518 DENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEE 582

  Fly   627 NIVLEE--RESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQLLVERFN 689
            |||.|:  :..:|:|:|||.|:.|||||||||:||||.||||||||||.||.||:||.||:|||.
Human   583 NIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFE 647

  Fly   690 IPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYD 754
            ||:|.....|......|           :.....|.||:|||||||||.|:|||.||||:|||||
Human   648 IPEPEPTDADKLAIEKG-----------EQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYD 701

  Fly   755 FEKDPMLLEKLLNFLEHVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVP 819
            ||:|..|||:|.:|:..|.||:|:|||:|:.||::||.:.:.:.......:...|||||.|:|.|
Human   702 FERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKP 766

  Fly   820 N--DEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTR 882
            .  :...|:||||:|:||||||||.::|:.|:|||||||.|||:|||:.||||||:::||||:|.
Human   767 GQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL 831

  Fly   883 WIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYR 947
            |.||.|.||||:|||:|::.|.||::.|..:||||||:|.||:|:.:.|||||..||:.|.||.|
Human   832 WFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKR 896

  Fly   948 KFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLL--ANTELINFSKRRK 1010
            |.|:|..|||.||.|||..:|:|||||||||||.||||||..||||.|.|  ...:|||||||||
Human   897 KILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRK 961

  Fly  1011 VAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFP 1075
            ||||.|||||||||||||..|..:|:|||.|:|....|:|:.:|||:|:||.||||.||..|:||
Human   962 VAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFP 1026

  Fly  1076 RKWPHIPLKSPGIKPR--RQNQTNSS------------SKLSNSTSSVAAAAAASSTATSIATAS 1126
            || ....||||||:|.  |...|:.:            .|:|.|..:.....:..|..||..|.|
Human  1027 RK-STFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPS 1090

  Fly  1127 APSLHASSIMDAPTAAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSWSGTPQHTRTDQ 1191
            .|.:.|||.:........|:..|             :.|:||||::|...:...|....|..::
Human  1091 TPPVSASSDLSVFLDVDLNSSCG-------------SNSIFAPVLLPHSKSFFSSCGSLHKLSE- 1141

  Fly  1192 NNGEVSVPAPHLPKKPGAHVWANNNSTLASASAMDVVFSPALPEHLPPQSLPDSNP--------F 1248
               |..:|.|..|:|...|..:|:...:.|...     .||:|...||.  |...|        |
Human  1142 ---EPLIPPPLPPRKKFDHDASNSKGNMKSDDD-----PPAIPPRQPPP--PKVKPRVPVPTGAF 1196

  Fly  1249 ASDTEAPPSPLPKLVVSPRHETGN----RSPFH-----GRMQNSPT-HSTASTVTLTGMSTSGGE 1303
            .....:||.|.|:   .|..:|..    |.|.|     ..:|..|. |....:..|..:||
Human  1197 DGPLHSPPPPPPR---DPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDIST---- 1254

  Fly  1304 EFCAGGFYFNSAHQGQPGAVPISPHVNVP-----MATNMEYRAVP--PPLPPRRKERTESCADMA 1361
              |.     ||     |...|.:|...||     ::::....|.|  ||:|||
Human  1255 --CP-----NS-----PSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPR------------ 1295

  Fly  1362 QKRQAPDAPTLPPR--DGELSPPPI 1384
             :..:|..|.|||:  ..|||.||:
Human  1296 -QNSSPHLPKLPPKTYKRELSHPPL 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551	67/127 (53%)
		H2A	155..>196	CDD:305064	25/40 (63%)
		RhoGEF	249..432	CDD:238091	80/189 (42%)
		PH_SOS	476..586	CDD:269963	48/109 (44%)
		PH	482..587	CDD:278594	43/104 (41%)
		RasGEFN	637..791	CDD:214571	88/153 (58%)
		RasGEF	825..1062	CDD:238087	152/238 (64%)
SOS2	NP_008870.2	Histone	63..169	CDD:329110	58/107 (54%)
		RhoGEF	199..386	CDD:238091	80/189 (42%)
		PH_SOS	437..543	CDD:269963	48/110 (44%)
		RasGEFN	595..739	CDD:214571	89/154 (58%)
		RasGEF	774..1013	CDD:238087	152/238 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1018..1061		16/43 (37%)
		NupH_GANP	<1023..>1142	CDD:318883	36/136 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1076..1096		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1142..1332		56/217 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I2281
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1040	1.000	Inparanoid score	I268
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45786
OrthoDB	1	1.010	-	-		D262477at33208
OrthoFinder	1	1.000	-	-		FOG0002651
OrthoInspector	1	1.000	-	-		otm42213
orthoMCL	1	0.900	-	-		OOG6_101209
Panther	1	1.100	-	-	LDO	PTHR23113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	1	1.000	-	-		X2024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870