Protein Alignment Sos and SOS2

DIOPT Version :10

• Sequence 1: NP_476597.2
• Gene: Sos / 34790
• FlyBaseID: FBgn0001965
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: XP_047287669.1
• Gene: SOS2 / 6655
• HGNCID: 11188
• Length: 1397
• Species: Homo sapiens
• Alignment Length: 1455
• Identity: 611/1455 - (41%)
• Similarity: 840/1455 - (57%)
• Gaps: 206/1455 - (14%)

  Fly    58 YDFTKCENAARWRGLFTPSLKK------------------------------------------- 79
            |:|...||:.:||||...:|:|
Human     8 YEFFSEENSPKWRGLLVSALRKMESRFFARLGCSGAILAHCNLHLSGSSDSPASASRVAGTTGVC 72

  Fly    80 ----VLEQVHPRVTAKEDALLYVEKLCLRLLAMLCAKPLPHSVQDVEEKVNKSFPAPIDQWALNE 140
                |.|||||.::|.|::|.|:|:|..:||..||... |.:||||||:|.|:||.|||:||:.:
Human    73 HHAQVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQ-PRTVQDVEERVQKTFPHPIDKWAIAD 136

  Fly   141 AKEVINSKKRKS--VLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVLEYISADILKMAGDYVIKIA 203
            |:..|..:||::  :||.:|:|..| |:||.||:|..||.::|||||||||||||:||:||..|.
Human   137 AQSAIEKRKRRNPLLLPVDKIHPSL-KEVLGYKVDYHVSLYIVAVLEYISADILKLAGNYVFNIR 200

  Fly   204 HCEITKEDIEVVMNADR------------------VLMDMLNQSEAHILPSPLSLPAQRASATYE 250
            |.||:::||:|.|.||:                  |||||.:|.:..::......|:......|.
Human   201 HYEISQQDIKVSMCADKPLVTTFYSASMSLFQIPHVLMDMFDQDDIGLVSLCEDEPSSSGELNYY 265

  Fly   251 ETVKELIHDEKQYQRDLHMIIRVFREELVKIVSD-----PRELEPIFSNIMDIYEVTVTLLGSLE 310
            :.|:..|.:|:||.|:|:|||:||||   ..:||     |.::|.|||||.||:|:||.|||.:|
Human   266 DLVRTEIAEERQYLRELNMIIKVFRE---AFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIE 327

  Fly   311 DVIEMSQEQSA-PCVGSCFEELAEAEEFDVYKKYAYDVTSQASRDALNNLLSKPG-ASSLTTAGH 373
            |.:||:.|.|. |..|||||:|||.:.||.|:..:.|:.|....:..|.|:::|. |....:...
Human   328 DTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFHEHFNKLMARPAVALHFQSIAD 392

  Fly   374 GFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMASL 438
            ||::||:|.||:|:|||:.|.:.||:.:|.||..|..|:|.|...|....|..|...::::....
Human   393 GFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRIYKQY 457

  Fly   439 SKERQV--PV----SGRVR-RQLAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSGKRI 496
            |..|:.  ||    |.::| :.|||::..|:|..::.||.||:||.|||||.|..|:::|:.
Human   458 SPRRRPGDPVCPFYSHQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAK--- 519

  Fly   497 WSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSFELAPR 561
             .||.:|||||||:.||.| ..||...|.::.:||||||:.||::.|.|:.|:.:.|::|||..:
Human   520 -HERHIFLFDGLMISCKPN-HGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDTCEHKHAFELVSK 582

  Fly   562 MQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAVPDSGD 626
            .:..|:..||:|:.|::|||.|:.:..:|.|||.|||:|...|.:.|||:||||:|:|.|.||.:
Human   583 DENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEE 647

  Fly   627 NIVLEE--RESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQLLVERFN 689
            |||.|:  :..:|:|:|||.|:.|||||||||:||||.||||||||||.||.||:||.||:|||.
Human   648 NIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFE 712

  Fly   690 IPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYD 754
            ||:|.....|......|           :.....|.||:|||||||||.|:|||.||||:|||||
Human   713 IPEPEPTDADKLAIEKG-----------EQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYD 766

  Fly   755 FEKDPMLLEKLLNFLEHVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVP 819
            ||:|..|||:|.:|:..|.||:|:|||:|:.||::||.:.:.:.......:...|||||.|:|.|
Human   767 FERDLELLERLESFISSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKP 831

  Fly   820 N--DEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTR 882
            .  :...|:||||:|:||||||||.::|:.|:|||||||.|||:|||:.||||||:::||||:|.
Human   832 GQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL 896

  Fly   883 WIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYR 947
            |.||.|.||||:|||:|::.|.||::.|..:||||||:|.||:|:.:.|||||..||:.|.||.|
Human   897 WFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKR 961

  Fly   948 KFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLL--ANTELINFSKRRK 1010
            |.|:|..|||.||.|||..:|:|||||||||||.||||||..||||.|.|  ...:|||||||||
Human   962 KILDEAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRK 1026

  Fly  1011 VAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFP 1075
            ||||.|||||||||||||..|..:|:|||.|:|....|:|:.:|||:|:||.||||.||..|:||
Human  1027 VAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCKQPPRFP 1091

  Fly  1076 RKWPHIPLKSPGIKPR--RQNQTNSS------------SKLSNSTSSVAAAAAASSTATSIATAS 1126
            || ....||||||:|.  |...|:.:            .|:|.|..:.....:..|..||..|.|
Human  1092 RK-STFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPCKISFSRIAETELESTVSAPTSPNTPS 1155

  Fly  1127 APSLHASSIMDAPTAAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSWSGTPQHTRTDQ 1191
            .|.:.|||.:........|:..|             :.|:||||::|...:...|....|..::
Human  1156 TPPVSASSDLSVFLDVDLNSSCG-------------SNSIFAPVLLPHSKSFFSSCGSLHKLSE- 1206

  Fly  1192 NNGEVSVPAPHLPKKPGAHVWANNNSTLASASAMDVVFSPALPEHLPPQSLPDSNP--------F 1248
               |..:|.|..|:|...|..:|:...:.|...     .||:|...||.  |...|        |
Human  1207 ---EPLIPPPLPPRKKFDHDASNSKGNMKSDDD-----PPAIPPRQPPP--PKVKPRVPVPTGAF 1261

  Fly  1249 ASDTEAPPSPLPKLVVSPRHETGN----RSPFH-----GRMQNSPT-HSTASTVTLTGMSTSGGE 1303
            .....:||.|.|:   .|..:|..    |.|.|     ..:|..|. |....:..|..:||
Human  1262 DGPLHSPPPPPPR---DPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDSDWLRDIST---- 1319

  Fly  1304 EFCAGGFYFNSAHQGQPGAVPISPHVNVP-----MATNMEYRAVP--PPLPPRRKERTESCADMA 1361
              |.     ||     |...|.:|...||     ::::....|.|  ||:|||
Human  1320 --CP-----NS-----PSTPPSTPSPRVPRRCYVLSSSQNNLAHPPAPPVPPR------------ 1360

  Fly  1362 QKRQAPDAPTLPPR--DGELSPPPI 1384
             :..:|..|.|||:  ..|||.||:
Human  1361 -QNSSPHLPKLPPKTYKRELSHPPL 1384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	HFD_SOS1_rpt1	68..145	CDD:467039	39/123 (32%)
		HFD_SOS1_rpt2	153..227	CDD:467040	45/91 (49%)
		RhoGEF	249..432	CDD:238091	80/189 (42%)
		PH_SOS	476..586	CDD:269963	48/109 (44%)
		RasGEFN	637..791	CDD:214571	88/153 (58%)
		RasGEF	825..1062	CDD:238087	152/238 (64%)
		PHA03247	<1197..1502	CDD:223021	55/215 (26%)
SOS2	XP_047287669.1	HFD_SOS1_rpt1	18..142	CDD:467039	39/124 (31%)
		HFD_SOS1_rpt2	151..219	CDD:467040	40/68 (59%)
		RhoGEF	264..451	CDD:238091	80/189 (42%)
		PH_SOS	502..608	CDD:269963	48/110 (44%)
		RasGEFN	660..804	CDD:214571	89/154 (58%)
		RasGEF	839..1078	CDD:238087	152/238 (64%)