DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sos and SOS1

DIOPT Version :9

Sequence 1:NP_476597.2 Gene:Sos / 34790 FlyBaseID:FBgn0001965 Length:1596 Species:Drosophila melanogaster
Sequence 2:NP_005624.2 Gene:SOS1 / 6654 HGNCID:11187 Length:1333 Species:Homo sapiens


Alignment Length:1507 Identity:619/1507 - (41%)
Similarity:853/1507 - (56%) Gaps:235/1507 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 YDFTKCENAARWRGLFTPSLKKVLEQVHPRVTAKEDALLYVEKLCLRLLAMLCAKPLPHSVQDVE 122
            |:|...|||.:||||..|:||||..||||.:.:.:|||.|||:|.|:||.||| :..|.|..|||
Human     8 YEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC-QAQPRSASDVE 71

  Fly   123 EKVNKSFPAPIDQWALNEAKEVINSKKRKS--VLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVLE 185
            |:|.||||.|||:||:.:|:..|..:||::  .||.||:|.|| |:||.||||..||.::|||||
Human    72 ERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLL-KEVLGYKIDHQVSVYIVAVLE 135

  Fly   186 YISADILKMAGDYVIKIAHCEITKEDIEVVMNADRVLMDMLNQ--SEAHILPSPLSLPAQRASAT 248
            ||||||||:.|:||..|.|.||||:||:|.|.||:|||||.:|  .:.:||......|:.....|
Human   136 YISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQT 200

  Fly   249 YEETVKELIHDEKQYQRDLHMIIRVFREELV---KIVSDPRELEPIFSNIMDIYEVTVTLLGSLE 310
            |.:.||..:.:.:||.|:|::||:||||..|   |:.| ..::|.|||.|:||:|::|.|||.:|
Human   201 YYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFS-ANDVENIFSRIVDIHELSVKLLGHIE 264

  Fly   311 DVIEMSQEQSA-PCVGSCFEELAEAEEFDVYKKYAYDVTSQASRDALNNLLSKPGAS-SLTTAGH 373
            |.:||:.|.|. |.||||||:|||...||.|:.||.|:......|...:.||||||: .|.:.|.
Human   265 DTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQLSKPGAALYLQSIGE 329

  Fly   374 GFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMA-S 437
            ||::||:|.||:|||.|:.|...||:.:|.|::.|..|:|.|..:|....|..:...:||:.: |
Human   330 GFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICSKS 394

  Fly   438 LSKERQVPVSGRV------RRQLAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSGKRI 496
            |:|.|....:.|.      .:||||::..|:|..::.||.||:||.|||||.|.:|:::|:.   
Human   395 LAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAK--- 456

  Fly   497 WSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSFELAPR 561
             .||.:|||||||:.||:| ..|....||:..:||||||:|||:|.|||:.|:::.|::||:..:
Human   457 -HERHIFLFDGLMICCKSN-HGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILK 519

  Fly   562 MQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAVPDSGD 626
            .:..::.:||:|:.|::|||.|:.:..:|.|:|.||..:...|::..:|:||.::|:||.|||.:
Human   520 DENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEE 584

  Fly   627 NIVLEE--RESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQLLVERFN 689
            ||:.||  :..||:|:||..|:.|||||||||:||||.||||||||||.||.||:||.|::|||.
Human   585 NIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFE 649

  Fly   690 IPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYD 754
            ||:|.....|.       :....||:...    .:.||:||||:||||.|||||.||||:|||||
Human   650 IPEPEPTEADR-------IAIENGDQPLS----AELKRFRKEYIQPVQLRVLNVCRHWVEHHFYD 703

  Fly   755 FEKDPMLLEKLLNFLEHVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVP 819
            ||:|..||:::..|:..|.||:|:|||:|:.||:|||.....:.......:...||.:|.|:|.|
Human   704 FERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRP 768

  Fly   820 N--DEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTR 882
            .  :...||||||:|:||||||||.::|:.|:|||||||.|||:|||:.||||||:::||||:|.
Human   769 GHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL 833

  Fly   883 WIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYR 947
            |.||.|.|.||.|||:|::.|.||::.|..|||||||:|.:|:||.::.||||..||:.:|.|.:
Human   834 WFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQK 898

  Fly   948 KFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLA--NTELINFSKRRK 1010
            |.|||..|||:||.|||..:|||||||||||||.||||||..|||||::|.  ..||||||||||
Human   899 KILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRK 963

  Fly  1011 VAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFP 1075
            ||||.|||||||||||||..||.|::|||.|:|.....:|:.:|||:|:||.||||..|.:|:||
Human   964 VAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFP 1028

  Fly  1076 RKWPHIPLKSPGIKPRRQNQTNSSSKLSNSTSSVAAAAAASSTATSIATASAPSLHASSIMDAPT 1140
            :|:.: ||||||::|                                                  
Human  1029 KKYSY-PLKSPGVRP-------------------------------------------------- 1042

  Fly  1141 AAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSWSGTPQHTRTDQNNGEVSVPAPHLPK 1205
               :|...||:......|..|...|...   |||..|.|.:..|...||              |.
Human  1043 ---SNPRPGTMRHPTPLQQEPRKISYSR---IPESETESTASAPNSPRT--------------PL 1087

  Fly  1206 KPGAHVWANNNSTLASA----------SAMDVVFSPALPEHLPPQSLPDSNPFASDTEAPPSPLP 1260
            .|.....|::.:.:.|.          |:.|.||......|.|..:...|......|:..|.|.|
Human  1088 TPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISLTKGTDEVPVPPP 1152

  Fly  1261 KLVVSPRHETGNRSPFHGRMQNSPTHSTASTVTLTGMSTSGGEEFCAGGFYFNSAHQGQPGAVP- 1324
               |.||.          |.:::|..|:.|.:.                    |.|...|.|:| 
Human  1153 ---VPPRR----------RPESAPAESSPSKIM--------------------SKHLDSPPAIPP 1184

  Fly  1325 -------ISPHVNVPMATNM-EYRAVPPPLPPRRKERTESCADMAQKRQAPDAPTLPPRDGELSP 1381
                   .||..::...|:: :....||.||||...||            ||..:..|.  .|.|
Human  1185 RQPTSKAYSPRYSISDRTSISDPPESPPLLPPREPVRT------------PDVFSSSPL--HLQP 1235

  Fly  1382 PPIPPRLNHSTGISYLRQSHGKSKEFVGNSSLLLPNTSSIMIRRNSAIEKRAAATSQPNQAAAGP 1446
            ||:..:.:|                  ||:  ..||:.|             ..|..|.|..:  
Human  1236 PPLGKKSDH------------------GNA--FFPNSPS-------------PFTPPPPQTPS-- 1265

  Fly  1447 ISTTLVTVSQAVATDEPLPLPISPAASSSTTTSPLTPAMSPMSPNIPSHPVESTSSSYAHQLRMR 1511
                      ...|...||.|            |||..:...|...|..|...::|.:..:|..:
Human  1266 ----------PHGTRRHLPSP------------PLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPK 1308

  Fly  1512 QQQQQQTHPAIY 1523
            ..:::.|||:::
Human  1309 TYKREHTHPSMH 1320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SosNP_476597.2 Histone 90..216 CDD:278551 74/127 (58%)
H2A 155..>196 CDD:305064 28/40 (70%)
RhoGEF 249..432 CDD:238091 81/187 (43%)
PH_SOS 476..586 CDD:269963 49/109 (45%)
PH 482..587 CDD:278594 44/104 (42%)
RasGEFN 637..791 CDD:214571 85/153 (56%)
RasGEF 825..1062 CDD:238087 153/238 (64%)
SOS1NP_005624.2 Histone 63..169 CDD:333859 62/106 (58%)
RhoGEF 204..389 CDD:214619 80/185 (43%)
PH_SOS 439..545 CDD:269963 49/110 (45%)
RasGEFN 597..741 CDD:214571 86/154 (56%)
RasGEF 776..1015 CDD:238087 153/238 (64%)
PTZ00449 <1018..1319 CDD:185628 97/475 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1019..1103 30/154 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1129..1333 60/296 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 239 1.000 Domainoid score I2281
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4117
Inparanoid 1 1.050 1040 1.000 Inparanoid score I268
Isobase 1 0.950 - 0 Normalized mean entropy S3092
OMA 1 1.010 - - QHG45786
OrthoDB 1 1.010 - - D262477at33208
OrthoFinder 1 1.000 - - FOG0002651
OrthoInspector 1 1.000 - - otm42213
orthoMCL 1 0.900 - - OOG6_101209
Panther 1 1.100 - - O PTHR23113
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 1 1.000 - - X2024
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.960

Return to query results.
Submit another query.