DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sos and Rapgef1

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	XP_038962085.1	Gene:	Rapgef1 / 63881	RGDID:	619793	Length:	1269	Species:	Rattus norvegicus

Alignment Length:	923	Identity:	197/923 - (21%)
Similarity:	355/923 - (38%)	Gaps:	257/923 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 DMLNQSEAHILPSPLSLP--------AQRASATYEE-----TVKELIHDEKQ-----YQRDLHMI 270
            |.:::.:......|:|.|        .|.||:|..|     :|.|...|.::     .:::.||:
  Rat   511 DNISEDDLQNPAQPVSYPPFAAILPFQQGASSTPVEFVGDFSVPESAGDPEKPPPLPEKKNKHML 575

  Fly   271 IRVFREELVKIVSDPR--------ELEPIFSN----IMDIYEVTVTLLGSLEDVIEMSQEQSAPC 323
            ..:   :|::..|:|:        :.|.|:..    :|::|..:.:..|| :...|::...:.|.
  Rat   576 AYM---QLLEDYSEPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSDSFCGS-DSTQELAPPPALPP 636

  Fly   324 VGSCFEELAEAEEFDV-----YKKYAYDVTSQASRDAL-----NNLLSKPGASSLTTAGHGFRDA 378
            .....:....|..|.|     ..|.|:.....::...|     |:.|::.|:..:.:....||..
  Rat   637 KQRQLQASYAASSFSVSHCVQQTKVAFTPEDGSAAQGLSVSVSNSFLNRHGSLPVPSYKSVFRSY 701

  Fly   379 VKYYLP--KLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMASLSKE 441
            .:.::|  :..:.|.            |...|||.....          |:|       ||.|.:
  Rat   702 SQDFMPHHQASVQPF------------LPPTSSSSPHFP----------PVH-------ASQSSD 737

  Fly   442 RQVP---------VSGRVRRQLAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSGKRIW 497
            ..||         |.|.:...                              :|| |..|:..|:.
  Rat   738 LAVPTVSSPPPSTVDGPLSSS------------------------------QDS-SFHGNPVRLP 771

  Fly   498 SERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSFELAPR- 561
            ||..         ...::....:..||...|            |::.....:.:     ||||.
  Rat   772 SETS---------FTDSSENASSEEAGGGEY------------VNLYSSGQTSE-----ELAPSG 810

  Fly   562 MQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMP-----------SPE 615
            .:||   :.|:. |..|     |.|.:.|..|          .|::..|.|           ..|
  Rat   811 GEPP---SGKDG-HPRD-----LSVSSASGKD----------SRENGERSPKSLDALESAQSEEE 856

  Fly   616 IYKFAVPDSGD---NIVLEERESAGVPMIKGATLCKLIERLTYHIYADPT-------FVRTFLTT 670
            :.:.::.|..:   .:.|::....| |.::|.:...|:      ::|..|       :...||||
  Rat   857 VDELSLIDHNEIMARLTLKQEGDDG-PDVRGGSGDILL------VHATETDRKDLVLYCEAFLTT 914

  Fly   671 YRYFCSPQQLLQLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQP 735
            ||.|.||::|::.|..|:....|   :.||                           ::|...:.
  Rat   915 YRTFISPEELIKKLQCRYEKFSP---FADT---------------------------FKKRVSKN 949

  Fly   736 VQFRVLNVLRHWVDHHFYDFEKDPM----LLEKLLNFLEHVNGKSMRKWVDSVLKIVQRKNEQEK 796
            ..|.::.|:             |.:    |.|::|..|..:..:.:.....|:.::: |||..:|
  Rat   950 TFFVLVRVV-------------DELCLVELTEEILKLLMELVFRLVCSGELSLARVL-RKNILDK 1000

  Fly   797 SNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKK 861
            .::|.:....|...|:... .|.....||...|..|:|.|||||:.|::..::..|::  .|.|:
  Rat  1001 VDQKKLLRCAHSDQPLAAR-GVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKE 1062

  Fly   862 DKEVKSPNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAA 926
            ..|.|||||.:..:|..|::.|:...|...|..::|..::.:.|::|..:.:|||||..|:|::|
  Rat  1063 QNEEKSPNLTQFTEHFNNMSYWVRSVIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSA 1127

  Fly   927 MGTASVYRLRW---TFQGLPERYRKFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILH 988
            :.:|.:.||.|   |.:||.| |...::     |....:.|:..|..:.|||:|:.|..|.::..
  Rat  1128 LDSAPIRRLEWQRQTSEGLAE-YCTLID-----SSSSFRAYRAALSEVEPPCIPYLGLILQDLTF 1186

  Fly   989 LEEGNPDLLANTELINFSKRRKVAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMS 1053
            :..||||.:...  :|||||.:...|:..::.:|...|.:.....|..|      ||..||....
  Rat  1187 VHLGNPDYIDGK--VNFSKRWQQFNILDSMRCFQQVHYEIRRNDDIINF------FNDFSDHLAE 1243

  Fly  1054 DYLYNESLRIEPR 1066
            :.|:..||:|:||
  Rat  1244 EALWELSLKIKPR 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091	36/216 (17%)
		PH_SOS	476..586	CDD:269963	21/110 (19%)
		PH	482..587	CDD:278594	21/105 (20%)
		RasGEFN	637..791	CDD:214571	30/164 (18%)
		RasGEF	825..1062	CDD:238087	73/239 (31%)
Rapgef1	XP_038962085.1	PHA03247	<230..351	CDD:223021
		RasGEFN	880..1021	CDD:214571	37/192 (19%)
		RasGEF	1028..1257	CDD:214539	77/245 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810