DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sos and sos2

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_001334612.1	Gene:	sos2 / 561670	ZFINID:	ZDB-GENE-090319-5	Length:	1341	Species:	Danio rerio

Alignment Length:	1448	Identity:	614/1448 - (42%)
Similarity:	839/1448 - (57%)	Gaps:	189/1448 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 YDFTKC-ENAARWRGLFTPSLKKVLEQVHPRVTAKEDALLYVEKLCLRLLAMLCAKPLPHSVQDV 121
            :||:.. ||:|||||||...|:||..||||.::||||||.::|.|.|:||..||... |.::.||
Zfish     3 HDFSSSEENSARWRGLFVQGLRKVQVQVHPNLSAKEDALQHIEALILQLLNKLCVTQ-PRTIADV 66

  Fly   122 EEKVNKSFPAPIDQWALNEAKEVINSKKRKS--VLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVL 184
            |::|.|:||.|||:||:.:|:..|..:||::  :||.:|:|.|| |:||.||||.:|..::||||
Zfish    67 EDRVQKTFPNPIDKWAMGDAQNAIEKRKRRNPLLLPVDKIHPLL-KEVLGYKIDYNVCLYIVAVL 130

  Fly   185 EYISADILKMAGDYVIKIAHCEITKEDIEVVMNADRVLMDMLNQSEAHILPSPLSLPAQRASA-- 247
            |||||||||:||:||..|.|.||:::||.|.|.||:|||||.:|.|...|   ||...:..|:
Zfish   131 EYISADILKLAGNYVSNIRHYEISQQDITVSMCADKVLMDMFDQEEEMGL---LSQSVEEVSSSG 192

  Fly   248 --TYEETVKELIHDEKQYQRDLHMIIRVFREELV---KIVSDPRELEPIFSNIMDIYEVTVTLLG 307
              ||::.|:..|.:|:||.|:|.:||:|||:..:   |:.| .:::|..||||:::.|:||.|||
Zfish   193 VLTYDDLVRLEIAEERQYLRELDLIIKVFRQAFMSNSKLFS-AQDVELAFSNILEVQELTVKLLG 256

  Fly   308 SLEDVIEMSQEQSA-PCVGSCFEELAEAEEFDVYKKYAYDVTSQASRDALNNLLSKPGASSLTTA 371
            .:||.:||:.:.|. |.||||||:|||.:.||.|:..:.|:.|:......|.|:|:|     |.|
Zfish   257 LIEDAVEMTADGSPHPLVGSCFEDLAEEQAFDPYETLSQDILSKEFCQHFNTLMSRP-----TVA 316

  Fly   372 GH------GFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCD 430
            .|      ||::||:|.||:|::||:.|...||:.::.|::.|..|||.|..:|.|..|..|.|.
Zfish   317 LHFQSIAEGFKEAVQYVLPQLMMVPVYHCIHYFELLQQLQECSEEQDDRECLKQAQTALINLQCS 381

  Fly   431 LEKVMASLSKERQ-----VPVSGRVRR--QLAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLS 488
            :|::.|.....|:     ..:..|..|  |.||:|..::|..::.||.||:||.|::||.|.:|.
Zfish   382 IERIYAKHQPRRKQGEPLYRLYSRASRSKQAAIKRMNDIQKSIDGWEGKDIGQCCSQFILEGALL 446

  Fly   489 KLGSGKRIWSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLK 553
            :.|:.    .||..|||||||:.||||...:.|.||:.| ::|||||:.:|:..|.||.||.:.:
Zfish   447 RAGAK----HERHNFLFDGLMISCKANQSSRLPGAGSGA-EFRLKEKFVLRKYRIVDREDSPEFR 506

  Fly   554 NSFELAPRMQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYK 618
            ::|||..|.:...|.:|::|:.|..|||.|:.:..:..|||.||::|...|:..|||:|||::|:
Zfish   507 HAFELVGREESGAVFSARSAEEKSAWMAALVTLQYRPTLDRMLDTVLHREEQAQPLRLPSPDVYR 571

  Fly   619 FAVPDSGDNIVLEE--RESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLL 681
            ||:.||.:|||.||  :...|:|:||..|:.|||||||||:||||.||||||||||.||.||.||
Zfish   572 FAIQDSEENIVFEEGAQSKTGIPIIKAGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQDLL 636

  Fly   682 QLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHRE-----------DWKRYRKEYVQP 735
            .||:||..||:|                      |...:.||           :.:|:|:|||||
Zfish   637 TLLIERIEIPEP----------------------EPSEADREALWNGEQPMAAELQRFRREYVQP 679

  Fly   736 VQFRVLNVLRHWVDHHFYDFEKDPMLLEKLLNFL---EHVNGKSMRKWVDSVLKIVQRKNEQEKS 797
            ||.|||||.|.||:|||||||.||.|.|:|..:|   ..:.||||||||:|:.||::||.:.:.:
Zfish   680 VQLRVLNVFRQWVEHHFYDFENDPELYERLEGYLISTTQLRGKSMRKWVESISKIMRRKIQMQSN 744

  Fly   798 NKKIVYAYGHDPPPIEHHLSVPN--DEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTK 860
            .......:...|||||.|:|.|.  |...|:||||:|:||||||||.::|:.|:|||||||.|||
Zfish   745 GISHNITFESPPPPIEWHISRPGQVDTFDLMTLHPIEIARQLTLLESDLYRAVRPSELVGSVWTK 809

  Fly   861 KDKEVKSPNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVA 925
            :|||..|||||::::||||:|.|.||.|.||||.:||:|:..|.||::.|..|||||||:|.||:
Zfish   810 EDKEKNSPNLLRMIRHTTNLTLWFEKCIVEAENVDERVAVFSRIIEILQVFQELNNFNGVLEIVS 874

  Fly   926 AMGTASVYRLRWTFQGLPERYRKFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLE 990
            |:.:..||||..||:.:|||.|:.|||..|||.||.|||..:|:|||||||||||.||||||..|
Zfish   875 AINSVPVYRLDHTFEAVPERKRRILEEAVELSQDHFKKYLAKLKSINPPCVPFFGIYLTNILKTE 939

  Fly   991 EGNPDLLA--NTELINFSKRRKVAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMS 1053
            |||||.|.  ..||||||||||||||.|||||||||||||..|..|::|||.|:|...:::|..|
Zfish   940 EGNPDFLKRDGKELINFSKRRKVAEITGEIQQYQNQPYCLKVEHDIKRFFENLNPMGNMNEKDFS 1004

  Fly  1054 DYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQTNSSSKLSNSTSSVAAAAAASST 1118
            |||:|:||.||||..|..|:||||..: .|||||::|.|| .......|......:........|
Zfish  1005 DYLFNKSLEIEPRNSKQPPRFPRKTTY-SLKSPGVRPVRQ-AVGGGGTLKGHPVPLEREPPHKIT 1067

  Fly  1119 ATSIATA---SAPSLHASSIMDAPTAAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSW 1180
            ..|||..   :.|||..|.....|..:|::..:.....:..|..|.   ::||||.:|:....|.
Zfish  1068 FRSIAETEPETPPSLPTSPNTPTPPQSASSDFNSVFEQDFMPYGNN---TIFAPVFLPQSKFQSV 1129

  Fly  1181 SGTPQH-------------------TRTDQNNGEVSVPA--PHLPKKP--GAHVWANNNSTLASA 1222
            |....|                   |.:|:|:...|.||  |.||..|  ...|...|..|....
Zfish  1130 SCGSLHQLMSDEPLKPPPLPPRRKDTSSDKNSRSDSPPAIPPRLPPPPRLQPRVPVINGPTDGPL 1194

  Fly  1223 SAMDVVFSPALPEHLPPQSLPDSNPFASDTEAPPSPLPKLVVSPRHETGNRSPFHGRMQNSPTHS 1287
                    |:.|..||...|||:.|  ...:.||.......|:.:...|.|  ||.....||  |
Zfish  1195 --------PSPPPPLPRDPLPDTPP--PVPQRPPEIFINYPVNMQPSPGGR--FHWDFTTSP--S 1245

  Fly  1288 TASTVTLTGMSTSGGEEFCAGGFYFNSAHQGQPGAV-------PISPHVNVPMATNMEYRAVPPP 1345
            |.:|...|                 .|.....||..       |.:|.|:.|:..::     |||
Zfish  1246 TPNTPPGT-----------------PSPRAVLPGTPSPRVPRRPCTPSVSQPILVHL-----PPP 1288

  Fly  1346 LPPRRKERTESCADMAQKRQAPDAPTLPPRDGELSP-PPIPPRLNHSTGISYLRQSHGKSKEFVG 1409
            .|                     ||.:|||....|. |.:||:       :|.|:. .:|...:.
Zfish  1289 TP---------------------APPIPPRHNSTSALPKLPPK-------TYKREL-SQSSHTLS 1324

  Fly  1410 NSSLLLPNTSSIMIRRNS 1427
            ..||   :|.|::..|:|
Zfish  1325 QPSL---HTLSLVDNRDS 1339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551	68/127 (54%)
		H2A	155..>196	CDD:305064	26/40 (65%)
		RhoGEF	249..432	CDD:238091	77/192 (40%)
		PH_SOS	476..586	CDD:269963	47/109 (43%)
		PH	482..587	CDD:278594	44/104 (42%)
		RasGEFN	637..791	CDD:214571	85/167 (51%)
		RasGEF	825..1062	CDD:238087	152/238 (64%)
sos2	NP_001334612.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	242	1.000	Domainoid score	I2183
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1005	1.000	Inparanoid score	I284
OMA	1	1.010	-	-		QHG45786
OrthoDB	1	1.010	-	-		D262477at33208
OrthoFinder	1	1.000	-	-		FOG0002651
OrthoInspector	1	1.000	-	-		oto39670
orthoMCL	1	0.900	-	-		OOG6_101209
Panther	1	1.100	-	-	LDO	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2024
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840