Protein Alignment Sos and rapgef1a

DIOPT Version :9

• Sequence 1: NP_476597.2
• Gene: Sos / 34790
• FlyBaseID: FBgn0001965
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: XP_005166961.1
• Gene: rapgef1a / 558635
• ZFINID: ZDB-GENE-081105-26
• Length: 1085
• Species: Danio rerio
• Alignment Length: 1181
• Identity: 242/1181 - (20%)
• Similarity: 424/1181 - (35%)
• Gaps: 374/1181 - (31%)

  Fly   111 AKPLPHS-VQDVEEKVNKS-----------------FPAPIDQWALNEAKEVINSKKRKSVLP-- 155
            :||.|.. |:..|:.|.||                 |...||:.|::        ||...:||
Zfish    41 SKPPPEQPVKSPEKTVTKSLSRLEEHEKEVVSALRYFKTIIDKMAVD--------KKVLEMLPGS 97

  Fly   156 ----TEKVHTLLQKDVLQYKIDSS--VSAFLVAVLEYISADILKMAGDYVIKIAHCEITKEDIEV 214
                .|.|..|:|   |..||.||  ||:.|..:.:.: |::::.:...:::..:.| .|:.|..
Zfish    98 ASKVLEAVTGLVQ---LDSKILSSSRVSSCLNRLYQSL-ANLIRWSDQVMLEGVNLE-DKDTITT 157

  Fly   215 VMNADRVLMDMLN-------QSEAHILPS-------PLSLPAQRASATYEETVKELIHDEKQYQR 265
            |.|..:.::|.:.       :.:.|..|:       |::.|.:.......||.:.:::|......
Zfish   158 VTNVIKAVLDGVKELVKVAIEKQEHPSPTTPVKTIPPVASPQRVPEPPVIETKEPILNDSPAPAE 222

  Fly   266 DLHMIIRVFREEL---------VKIVSD---------PRELEPIFSNIMDIYEVTVTLLGSLEDV 312
            ::.....|..||:         :|:...         .|:..|..:.|..:..::.|..||
Zfish   223 NIETPNDVPEEEVAPPKPPLPGLKVPEQHCPPALPPKKRQSAPSPTRIAVVAPMSRTTSGS---- 283

  Fly   313 IEMSQEQSAPCVGSCFEELAEAEEFDVYKK------YAYDVTS------------QASRDALNNL 359
                   |.| :|.|.:|.    |.|..::      ::|...|            ..|.:.|::|
Zfish   284 -------SLP-IGICRQEY----EADALQRRFSGGSHSYGGESPRLSPCGSIGILSKSDEQLSSL 336

  Fly   360 LSKPGASSLTTAGHGFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQ--- 421
            ....|..|..|:.... |..:.|.|.            :|::         ..|:.|.||:.
Zfish   337 DQDSGQCSRNTSCETL-DTAESYDPD------------YDFL---------HQDLSSTEQIPHTH 379

  Fly   422 --GLLHPLHCDL-EKVMASLSKERQVPVSGRVRRQLAIERTRELQMKVEHWEDKDV--------- 474
              |.|.||...| |.....:..:...|...:..|:..:.....|..:.::..|:|:
Zfish   380 TGGCLSPLPESLHESSSFPVQHQSMPPALPKKERRPPLPPVERLYSQYDNVPDEDMHTPPFPLFG 444

  Fly   475 --------------GQNCNEFI----------REDSLSKLGSGKRIWSERKVFLFDGLMVLCKAN 515
                          |.:.|..|          :...:.|.......:||....:|
Zfish   445 AIPPSNPGVFMGNFGPSENTQIPQSPPPLPEKKSRHILKYMQFMEDYSEPLPSVF---------- 499

  Fly   516 TKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSFELAPRMQPPIVLTAKNAQHKHDWM 580
              .|||.: .:.|:.|.::::          .:...|.:||..:....||..|..|..|......
Zfish   500 --YQTPQS-ESIYEQRNRKRF----------QEVYGLSDSFSSSDETLPPPALPPKQRQLASSHS 551

  Fly   581 A------------DLLMVI-------TKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAVPDSGD 626
            |            .|...:       |:|.|.  |.:....:.|:..|.:|:.|    :..|.|.
Zfish   552 ASPSSSSSSSLSCQLQQCVSGPGPGETESTLS--LSASNSSLNREGSLPVPTSE----SANDEGG 610

  Fly   627 -----NIVLEERESAGVPMIKGATLC--------------------------------------- 647
                 |:....:.:..|.:..|.:.|
Zfish   611 EGEYVNLYSSNQANGDVTLSNGDSFCGAEDSPQDSAIEHSKDPADREGWKQKCVDSDLTSEEVDE 675

  Fly   648 -------KLIERLTYH------------------IYADPT-------FVRTFLTTYRYFCSPQQL 680
                   :::.|:|..                  ::|..|       :...||||||.|.:|:.|
Zfish   676 LCLIDHDEIMSRITLKQENDDGPDVRAGSGDILLVHATETDRKDRVLYCEAFLTTYRTFLTPEDL 740

  Fly   681 LQLL---VERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLN 742
            ::.|   ..||::...|:                 ..:..||:..             |..||::
Zfish   741 IKKLRYRYTRFSLSSDSI-----------------KQRASKNTFF-------------VLVRVVD 775

  Fly   743 VLRHWVDHHFYDFEKD--PMLLEKLLNFL---EHVNGKSMRKWVDSVL-KIVQRKNEQEKSNKKI 801
            .|      ...:..:|  ..|:|.:.|.|   |....:.:||   ::| |:.|:|..|..::.|.
Zfish   776 EL------CLVELTEDILKQLMELVFNLLCKGELTLARVLRK---NILDKVQQKKLLQYTNSLKT 831

  Fly   802 VYAYGHDPPPIEHHLSVPNDEITLLTLHPL---ELARQLTLLEFEMYKNVKPSELVGSPWTKKDK 863
            :.|.|....|              .|||..   |:|.|||||:.|::..::..|::  .|.|:..
Zfish   832 LAARGVAARP--------------GTLHDFRSHEIADQLTLLDAELFYKIEIPEVL--LWAKEQN 880

  Fly   864 EVKSPNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMG 928
            |.|||||.:..:|..|::.|:...|...|..::|..::.:.|::|..:.:|||||..|:|::|:.
Zfish   881 EEKSPNLTQFTEHFNNMSYWVRSIIILQEKAQDREKLLLKFIKIMKHLRKLNNFNSYLAILSALD 945

  Fly   929 TASVYRLRW---TFQGLPERYRKFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLE 990
            :|.:.||.|   |.:|| |.|...::     |....:.|:..|..:.|||:|:.|..|.::..:.
Zfish   946 SAPIRRLEWQKQTSEGL-EEYCTLID-----SSSSFRAYRAALADVEPPCIPYLGLILQDLTFVH 1004

  Fly   991 EGNPDLLANTELINFSKRRKVAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDY 1055
            .||||.:...  ||||||.:...|:..::::|...|.|.....|..|      ||..||....:.
Zfish  1005 LGNPDHIEGK--INFSKRWQQFNILDTMRRFQQVHYDLKHNDDIVSF------FNDFSDHLAEEA 1061

  Fly  1056 LYNESLRIEPR 1066
            |:..||:|:||
Zfish  1062 LWELSLKIKPR 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551	32/130 (25%)
		H2A	155..>196	CDD:305064	14/48 (29%)
		RhoGEF	249..432	CDD:238091	41/224 (18%)
		PH_SOS	476..586	CDD:269963	21/131 (16%)
		PH	482..587	CDD:278594	20/126 (16%)
		RasGEFN	637..791	CDD:214571	37/233 (16%)
		RasGEF	825..1062	CDD:238087	76/242 (31%)
rapgef1a	XP_005166961.1	RasGEFN	696..837	CDD:214571	36/179 (20%)
		RasGEF	844..1073	CDD:214539	79/245 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840