DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sos and sos1

DIOPT Version :9

Sequence 1:NP_476597.2 Gene:Sos / 34790 FlyBaseID:FBgn0001965 Length:1596 Species:Drosophila melanogaster
Sequence 2:NP_001076462.1 Gene:sos1 / 556286 ZFINID:ZDB-GENE-070209-128 Length:713 Species:Danio rerio


Alignment Length:1379 Identity:341/1379 - (24%)
Similarity:455/1379 - (32%) Gaps:727/1379 - (52%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 YDFTKCENAARWRGLFTPSLKKVLEQVHPRVTAKEDALLYVEKLCLRLLAMLCAKPLPHSVQDVE 122
            |||...|||.:||||..|||.|||.||||:::::::||.|:|.|.|.||..|| :..|.:|||||
Zfish     8 YDFYSEENAHKWRGLLVPSLNKVLNQVHPKLSSQQEALQYIEGLILVLLNTLC-QAQPRTVQDVE 71

  Fly   123 EKVNKSFPAPIDQWALNEAKEVINSKKRKS--VLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVLE 185
            |:|.:|||.||::||:.:|:..|..:||::  .||.:|:|.|| |:||.||||..||.::|||||
Zfish    72 ERVQRSFPHPIEKWAIADAQAAIEKRKRRNPLALPVDKIHPLL-KEVLGYKIDHQVSVYIVAVLE 135

  Fly   186 YISADILKMAGDYVIKIAHCEITKEDIEVVMNADRVLMDMLNQSEAHILPSPLSLPAQRASATYE 250
            ||||||||:||:||..|.|.||:::||.|.|.||:|||||                         
Zfish   136 YISADILKLAGNYVRNIRHYEISQQDITVAMCADKVLMDM------------------------- 175

  Fly   251 ETVKELIHDEKQYQRDLHMIIRVFREELVKIVSDPRELEPIFSNIMDIYEVTVTLLGSLEDVIEM 315
                                                                             
Zfish   176 ----------------------------------------------------------------- 175

  Fly   316 SQEQSAPCVGSCFEELAEAEEFDVYKKYAYDVTSQASRDALNNLLSKPGASSLTTAGHGFRDAVK 380
                                                                             
Zfish   176 ----------------------------------------------------------------- 175

  Fly   381 YYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMASLSKERQVP 445
                                                                             
Zfish   176 ----------------------------------------------------------------- 175

  Fly   446 VSGRVRRQLAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSGKRIWSERKVFLFDGLMV 510
                                                                             
Zfish   176 ----------------------------------------------------------------- 175

  Fly   511 LCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSFELAPRMQPPIVLTAKNAQH 575
                                                                             
Zfish   176 ----------------------------------------------------------------- 175

  Fly   576 KHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAVPDSGDNIVLEERESAGVPM 640
                                                                             
Zfish   176 ----------------------------------------------------------------- 175

  Fly   641 IKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQDTGTAGA 705
                                                                             
Zfish   176 ----------------------------------------------------------------- 175

  Fly   706 GGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLEKLLNFLE 770
                                                                             
Zfish   176 ----------------------------------------------------------------- 175

  Fly   771 HVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELAR 835
                                                                     |||:|:||
Zfish   176 ---------------------------------------------------------LHPIEIAR 183

  Fly   836 QLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTRWIEKSITEAENYEERLAI 900
            ||||||.:.|:.|:|||||||.|||:|||:.|||||::::||||:|.|:||.|.|.||.|||:::
Zfish   184 QLTLLESDFYRAVQPSELVGSVWTKEDKEINSPNLLRMIRHTTNLTLWLEKCIVETENVEERVSV 248

  Fly   901 MQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECRELSDDHLKKYQ 965
            :.|.||::.|..|||||||:|.:|:||.::.||||..||:.:|.|.||.|||..|||:||.|||.
Zfish   249 VSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQRKILEEAHELSEDHYKKYL 313

  Fly   966 ERLRSINPPCVPFFGRYLTNILHLEEGNPDLLA--NTELINFSKRRKVAEIIGEIQQYQNQPYCL 1028
            .:|||||||||||||.||||||..||||||.|.  .|||||||||||||||.|||||||||||||
Zfish   314 AKLRSINPPCVPFFGIYLTNILKTEEGNPDFLKRHGTELINFSKRRKVAEITGEIQQYQNQPYCL 378

  Fly  1029 NEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRR- 1092
            ..|:.||:|||.|:|...:.:|:.:|||:|:||.||||..:|:|:|.:|: ..||||||::|.. 
Zfish   379 RVENDIRKFFENLNPMEDMMEKEFTDYLFNKSLEIEPRNARTLPRFAKKY-SCPLKSPGVRPSAV 442

  Fly  1093 -----------QNQTN--SSSKLSNSTSSVAAAAAASSTATSIA--TASAPSLHASSIMDAPTAA 1142
                       ||:..  |.|::.:|.:..:||:|.:|..|.:.  .|||.|....|:.|:|...
Zfish   443 RPGAMRHPTPLQNEPRKISYSRIPDSETESSAASAPNSPRTPLTPPPASAASTDTCSVFDSPQQP 507

  Fly  1143 AANAGSGTLAGEQSPQHNPHAFSVFAPVIIPE-RNTSSWSGTPQHTRTDQNNGEVSVPAPHLPKK 1206
            :            ||.|: ::..|||||.:|. ..:||.|......|.|    :..||.|..|::
Zfish   508 S------------SPFHS-NSECVFAPVALPHGPRSSSVSSMMGFLRND----DPPVPPPVPPRR 555

  Fly  1207 PGAHVWANNNSTLASASAMDVVFSPALPEHLPPQSLPDSNPFASDTEAPPSP--LPKLVVSPRHE 1269
            ......|.::.:...::.:|  ..||:|...|..|...| |..|.|:.|.||  ||     ||..
Zfish   556 RPESAPAESSPSKMMSTHLD--SPPAIPPRQPTSSKVYS-PRYSLTDPPESPPLLP-----PREP 612

  Fly  1270 TGNRSPFHGRMQNSPTHSTASTVTLTGMSTSGGEEFCAGGFYFNSAHQGQ-------------PG 1321
            .  |:|                           :.||:...:......|:             |.
Zfish   613 V--RTP---------------------------DVFCSSPLHLQPPPPGRRAPELQAFFPPQTPS 648

  Fly  1322 AVPISPHVNVPMATNMEYRAVPPPLPPRRKERTESCADMAQKRQAPDAPTLPPRDGELSPPPIPP 1386
            ..|:.|..:          ..|||.||.                   .|.:|||.....||...|
Zfish   649 PSPLGPRKH----------PEPPPEPPL-------------------GPPVPPRLSTAGPPAHIP 684

  Fly  1387 RLNHSTGISYLRQS 1400
            :|...|   |.|:|
Zfish   685 KLPPKT---YKRES 695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SosNP_476597.2 Histone 90..216 CDD:278551 68/127 (54%)
H2A 155..>196 CDD:305064 27/40 (68%)
RhoGEF 249..432 CDD:238091 0/182 (0%)
PH_SOS 476..586 CDD:269963 0/109 (0%)
PH 482..587 CDD:278594 0/104 (0%)
RasGEFN 637..791 CDD:214571 0/153 (0%)
RasGEF 825..1062 CDD:238087 151/238 (63%)
sos1NP_001076462.1 Histone 58..169 CDD:278551 61/112 (54%)
H2A 97..183 CDD:305064 53/688 (8%)
RasGEF 174..412 CDD:238087 153/839 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 242 1.000 Domainoid score I2183
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D262477at33208
OrthoFinder 1 1.000 - - FOG0002651
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101209
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 1 1.000 - - X2024
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
98.850

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