DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sos and Rasgef1b

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_665838.1	Gene:	Rasgef1b / 320292	MGIID:	2443755	Length:	473	Species:	Mus musculus

Alignment Length:	508	Identity:	109/508 - (21%)
Similarity:	187/508 - (36%)	Gaps:	111/508 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 MPSPEIYKFAVPDSGDNIVL---EERESAGVPMIKGATLCKLIERLTYHI------YADPTFVRT 666
            ||....:......||.|..|   .|....|:.......|...:|.|..|:      |.|.|::.|
Mouse     1 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFT 65

  Fly   667 FLTTYRYFCSPQQLL----QLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKR 727
            ||.:.|.|..|.:|:    .|.||...:.:                    ||.: ||..|:
Mouse    66 FLLSSRLFMHPYELMAKVCHLCVEHQRLSE--------------------GDGD-KNQMRK---- 105

  Fly   728 YRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPML--LEKLLNFLEHVNGKSMRKWVDSVLKIVQR 790
                 :.|   ::|.:|..|.:...|||..:.|:  |:.|.:.:.....::.||.|..:::.:.|
Mouse   106 -----IAP---KILQLLTEWTETFPYDFRDERMMRNLKDLAHRMASGEEQTYRKNVQQMMQCLIR 162

  Fly   791 K----NEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTL--------------HPLELARQL 837
            |    ::.|:...|:              .|...|.:|:|..              .|..||:||
Mouse   163 KLAALSQYEEVLAKL--------------SSTATDRLTVLKTKPQSIQRDIMTVCSDPYTLAQQL 213

  Fly   838 TLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTRWIE----------KSITEAE 892
            |.:|.|....:.|.|.| ..:.:||......:.....|.|.|:..::|          ..|....
Mouse   214 THIELERLNYIGPEEFV-QAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPV 277

  Fly   893 NYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECRELS 957
            ..:.|..:::..|:|......:.|||.:::|::.|..:.|.||:.|:..:.......||...:.|
Mouse   278 KKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPS 342

  Fly   958 DDHLKKYQERLR-----------SINPPCVPFFGRYLTNILHLEEGNPDLLANTELINFSKRRKV 1011
             .:...|:..||           |.....:|||...:.:|..|.||..:.|.|.. :||.|..::
Mouse   343 -SNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCVNRLPNGH-VNFEKFWEL 405

  Fly  1012 AEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIE 1064
            |:.:.|...::........:..:.|:...:..|:       .|.||..|...|
Mouse   406 AKQVSEFMTWKQVECPFERDRKVLQYLLSVPVFS-------EDALYLASYESE 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	36/165 (22%)
		RasGEF	825..1062	CDD:238087	58/271 (21%)
Rasgef1b	NP_665838.1	REM	42..167	CDD:100121	36/157 (23%)
Rasgef1b	NP_665838.1	RasGEF	209..403	CDD:366198	48/196 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810