DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sos and Rasgef1a

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	XP_232315.7	Gene:	Rasgef1a / 312664	RGDID:	1305836	Length:	489	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	104/506 - (20%)
Similarity:	191/506 - (37%)	Gaps:	128/506 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   624 SGDNIVLEERESAGVPMIKGATLCKLIERL--TYHIYADPTFVRTFLTTYRYFCSPQQLL----Q 682
            |.|.|..:.|.::|       :|..|:|.|  |...|.|.|::.|||.:.|.|..|..||    |
  Rat    43 SKDLIFQDGRLTSG-------SLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQ 100

  Fly   683 LLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHW 747
            :.:|:          :....||.                       .|..::....:::.:|:.|
  Rat   101 ICLEQ----------RQQLEAGP-----------------------EKAKLKSFSTKIVQLLKEW 132

  Fly   748 VDHHFYDFEKDPMLLEKLLNFLEH-------VNG---KSMRKWVDSVLKIVQRKNEQEKSNKKIV 802
            .:...|||:.:..:.|  |..:.|       .||   |::.:.:.|:|..:..:::.::..:|:.
  Rat   133 TEAFPYDFQDEKAMAE--LKAIAHRVTQCDEENGTVKKAITQMIQSLLLSLAARSQLQELREKLR 195

  Fly   803 YAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSEL--VGSPWTKKDKEV 865
            .......|.::........:|..:...||.||:|||.:|.|...:::|.:|  :.|.....|...
  Rat   196 SPVVDKGPVLKAKPPAAQKDILGVCSDPLVLAQQLTHIELERVNSIRPEDLMQIISHMDSLDNHR 260

  Fly   866 KSPNLLKI--------------MKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNN 916
            ...::.|.              |...|.|.|.::|        :.|..:::..|:|......:.|
  Rat   261 CRGDMTKTYSLEAYDNWFNCLSMLVATEVCRVVKK--------KHRTRMLEFFIDVARECFNIGN 317

  Fly   917 FNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECRELSDDH------LKKYQERLRSINPP- 974
            ||.:::|::.|..:.|.||:.|:..:.......||...:.|.:.      |:...:|.::.|..
  Rat   318 FNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQTANSSR 382

  Fly   975 ---CVPFFGRYLTNIL--------HLEEGNPDLLANTELINFSKRRKVAEIIGEIQQYQN----- 1023
               .:|.|..::.:|.        ||..|:         |||.|..:::..|.|...:..
  Rat   383 EKIVIPVFNLFVKDIYFLHKIHTNHLPSGH---------INFKKFWEISRQIHEFMTWTRVECPF 438

  Fly  1024 ------QPYCL-----NEESTIRQFFEQLDPFNGL---SDKQMSDYLYNES 1060
                  |.|.|     :||:.....||...|.|.:   |.|.:...|.|.:
  Rat   439 EKDKKIQSYLLTAPIYSEEALFIASFESEGPENHMEKDSWKALRTTLLNRA 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	35/169 (21%)
		RasGEF	825..1062	CDD:238087	62/289 (21%)
Rasgef1a	XP_232315.7	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910