DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sos and Rgl3

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_001100275.1	Gene:	Rgl3 / 300444	RGDID:	1309756	Length:	346	Species:	Rattus norvegicus

Alignment Length:	363	Identity:	90/363 - (24%)
Similarity:	144/363 - (39%)	Gaps:	99/363 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   706 GGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQF-----RVLNVLRHWVDHHFYDFEKDPMLLEKL 765
            ||.......:....:.|.|.||...   |.:.|     .|::||..|:..|..||...|
  Rat    10 GGSAASAQPQRGLETARVDSKRTEG---QDLNFSKNLRAVVSVLGSWLRDHPQDFRDPP------ 65

  Fly   766 LNFLEHVN--------------GKSMR---KWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIE 813
                :|.|              |..:|   |.::..||  :.|.||.:..:::.:|   .||
  Rat    66 ----DHQNLGDVRIFLGWAAPGGAEVREAEKLLEDFLK--EAKEEQTEGEQRLAWA---GPP--- 118

  Fly   814 HHLSVPNDEIT---------------LLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDK 863
            .....|..|..               ||.....|:|.||||::.|::..|:..|.:||.|:::|:
  Rat   119 WAAQSPRSEFAEDYSEEEGLRSEGPELLDFSVDEVAEQLTLMDVELFLRVRSCECLGSMWSQRDR 183

  Fly   864 EVK---SPNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRA------IEVMMVMLELNNFNG 919
            ...   ||.:...:.....||..:..|:..|..    ||..|||      |.:.....||.||:.
  Rat   184 PGAAGISPTVRATVAQFNAVTGCVLGSVLAAPG----LAASQRAQRIEKWIRIAQRCRELRNFSS 244

  Fly   920 ILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECRELS------DDHLKK----YQER------- 967
            :.:|::|:.:..:|||:.::..:.   |:.|...|:||      |:||..    .||.
  Rat   245 LRAILSALQSNPIYRLKRSWGAVS---REPLSVFRKLSQIFSDEDNHLSSRAILSQEETTEGPQG 306

  Fly   968 -------LRSINPP-CVPFFGRYLTNILHLEEGNPDLL 997
                   |.|..|| .||:.|.:||:::.|:...||:|
  Rat   307 DDCSPGSLPSKLPPGPVPYLGTFLTDLVMLDTALPDML 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	23/106 (22%)
		RasGEF	825..1062	CDD:238087	59/207 (29%)
Rgl3	NP_001100275.1	REM	<36..100	CDD:295342	16/75 (21%)
Rgl3	NP_001100275.1	RasGEF	152..345	CDD:279011	57/200 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910