DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sos and RAPGEF1

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	XP_011516871.1	Gene:	RAPGEF1 / 2889	HGNCID:	4568	Length:	1278	Species:	Homo sapiens

Alignment Length:	917	Identity:	198/917 - (21%)
Similarity:	349/917 - (38%)	Gaps:	254/917 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 QSEAHILPSPLS-----LPAQR--ASATYE----ETVKELIHDEKQ-----YQRDLHMIIRVFRE 276
            ||.|.|...|.:     ||.|.  :||..|    .|..|...|.::     .:::.||:..:
Human   525 QSTAPIPSVPYAPFAAILPFQHGGSSAPVEFVGDFTAPESTGDPEKPPPLPEKKNKHMLAYM--- 586

  Fly   277 ELVKIVSDPR--------ELEPIFSN----IMDIYEVTVTLLGSLEDVIEMS---------QEQS 320
            :|::..|:|:        :.|.|:..    :|::|..:.:..| ::.|.|::         ::..
Human   587 QLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSG-VDSVQELAPPPALPPKQRQLQ 650

  Fly   321 APCVGSCFEELAEAEEFDVYKKYAYDVTSQASRDAL-----NNLLSKPGASSLTTAGHGFRDAVK 380
            |.|..|.|..::...:   ..|.|:.....::...|     |:.||:.|:..:.:....||...:
Human   651 ASCAASSFSSVSHCVQ---QTKVAFTPEDGSAAQGLSVSVSNSFLSRHGSLPVPSYKSVFRSYSQ 712

  Fly   381 YYLPKLLLVPICHAFVYFDYIKH--------LKDLSSSQDDIESFEQVQGLLHPLHCDL------ 431
                              |::.|        |...|||........|.|.      .||
Human   713 ------------------DFVPHHQASVPPFLPPTSSSSPHFPPAHQSQS------SDLAVPTMA 753

  Fly   432 ----EKVMASLSKERQVPVSGRVRRQLAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLSKL-G 491
                ..|...||..::....|         .|..|..:...   .|..:|.:|...|.....| .
Human   754 GPPPSTVDGPLSASQESSFHG---------NTVCLPSETSF---TDSSENASEEAGEGEYVNLYS 806

  Fly   492 SGKRIWSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSF 556
            ||:                    ::::..||.|.....   |:.:......::..|..|. ::..
Human   807 SGQ--------------------SSEELAPSRGEPPAG---KDGHPRDPSAVSGVPGKDS-RDGS 847

  Fly   557 ELAPRMQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAV 621
            |.||:  .|..|.:..::.:.|.:         |::|.:      :|..:..|:....:     .
Human   848 ERAPK--SPDALESAQSEEEVDEL---------SLIDHN------EIMSRLTLKQEGDD-----G 890

  Fly   622 PD----SGDNIVLEERESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQ 682
            ||    |||.:::...|:               :|....:|.:     .||||||.|.||::|::
Human   891 PDVRGGSGDILLVHATET---------------DRKDLVLYCE-----AFLTTYRTFISPEELIK 935

  Fly   683 LLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHW 747
            .|..|:....|   :.||                           ::|...:...|.::.|:
Human   936 KLQYRYEKFSP---FADT---------------------------FKKRVSKNTFFVLVRVV--- 967

  Fly   748 VDHHFYDFEKDPM----LLEKLLNFLEHV------NGKSMRKWVDSVLKIVQRKNEQEKSNKKIV 802
                      |.:    |.|::|..|..:      ||       :..|..|.|||..:|.::|.:
Human   968 ----------DELCLVELTEEILKLLMELVFRLVCNG-------ELSLARVLRKNILDKVDQKKL 1015

  Fly   803 YAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKS 867
            ........|:... .|.....||...|..|:|.|||||:.|::..::..|::  .|.|:..|.||
Human  1016 LRCATSSQPLAAR-GVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVL--LWAKEQNEEKS 1077

  Fly   868 PNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASV 932
            |||.:..:|..|::.|:...|...|..::|..::.:.|::|..:.:|||||..|:|::|:.:|.:
Human  1078 PNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPI 1142

  Fly   933 YRLRW---TFQGLPERYRKFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNP 994
            .||.|   |.:||.| |...::     |....:.|:..|..:.|||:|:.|..|.::..:..|||
Human  1143 RRLEWQKQTSEGLAE-YCTLID-----SSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNP 1201

  Fly   995 DLLANTELINFSKRRKVAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNE 1059
            |.:...  :|||||.:...|:..::.:|...|.:.....|..|      ||..||....:.|:..
Human  1202 DYIDGK--VNFSKRWQQFNILDSMRCFQQAHYDMRRNDDIINF------FNDFSDHLAEEALWEL 1258

  Fly  1060 SLRIEPR 1066
            ||:|:||
Human  1259 SLKIKPR 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091	39/235 (17%)
		PH_SOS	476..586	CDD:269963	18/110 (16%)
		PH	482..587	CDD:278594	16/105 (15%)
		RasGEFN	637..791	CDD:214571	29/163 (18%)
		RasGEF	825..1062	CDD:238087	73/239 (31%)
RAPGEF1	XP_011516871.1	RasGEFN	889..1030	CDD:214571	41/216 (19%)
RAPGEF1	XP_011516871.1	RasGEF	1037..1266	CDD:214539	77/245 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840