Protein Alignment Sos and CG7369

DIOPT Version :9

• Sequence 1: NP_476597.2
• Gene: Sos / 34790
• FlyBaseID: FBgn0001965
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: NP_649415.2
• Gene: CG7369 / 2768961
• FlyBaseID: FBgn0037188
• Length: 680
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 132/629 - (20%)
• Similarity: 221/629 - (35%)
• Gaps: 191/629 - (30%)

  Fly   577 HDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAVPDS---GDNIVLEERE---- 634
            |..:.||....:.|..  |....|..:.|...|..|..::..:....|   |.    |.||
  Fly    53 HKTLPDLKTQRSNSAC--HAHESLSALRRIALLEKPPEKLLSYGAAQSRILGQ----EAREDFLV 111

  Fly   635 -SAGVPMIKGATLCKLIERL--TYHIYADPTFVRTFLTTYRYFCSPQQLLQLLVERFNIPDPSLV 696
             |.|  .:....|..||..:  |:..|.|..|:..||.:.|.|..|.:||..:.:.:....
  Fly   112 YSEG--RLHSGPLQSLIAHMVPTHEYYPDEGFIFAFLLSARLFVRPHELLAQISQTWEHQQ---- 170

  Fly   697 YQDTGTAG-----AG-GMG-----------------GVGGDKEHKNSHREDWKRYRKEYVQPVQF 738
             ||.||.|     || |.|                 |......| :|..|...:.|....:..|
  Fly   171 -QDVGTGGDVVDDAGQGPGRTMMVSINSASPLTQRKGSAAAASH-SSELEPRLQQRTNTQRSAQ- 232

  Fly   739 RVLNVLRHWVDHHFYDFEKDPMLLEK---LLNFLEHVNGKSMRKWVDSVLKIVQRK--------- 791
            ..:.:|..|::...||| :|..|:::   |.....::: .|:.|.|..:|:::..:
  Fly   233 HCIRLLSEWIEIFPYDF-RDERLMQQVRILARKCVYID-NSLGKQVSRILQLLVSRLTTLEQYEE 295

  Fly   792 -------NEQEKSNKKIVYAYGHDPPPIEHHL--------------------------------- 816
                   .|.:...::..:.:||     .:||
  Fly   296 FLQTISSEEAQSQQQQHHHHHGH-----HNHLHNAFQTFLGSSSHANGASGGGGSASGTSNSSSS 355

  Fly   817 ----------SV-----PNDEITLLTLHP--LELARQLTLLEFEMYKNVKPSELVGSPWTK---- 860
                      |:     |:|...::.:.|  ..||.|||.:|.|...::.|.|.| ..:.|
  Fly   356 GHTSSASTSNSISTTPQPDDVFGIMDMCPSCAHLAHQLTAIELERLSHIGPEEFV-QAFAKDYQQ 419

  Fly   861 --KDKEVKSPN---------LLKIMKHTTNVTRWIE----------KSITEAENYEERLAIMQRA 904
              ||...::.|         .|..||.|.|:..:::          ..|.:....::|:.|::..
  Fly   420 QAKDGSREANNSKCSGGGGGSLNDMKKTRNLESYVQWFNRLSYLTASEIVKYPKKKQRVRIIEYW 484

  Fly   905 IEVMMVMLELNNFNGILSIVAAMGTASVYRLRWT--------FQGLPER---------YRKFLEE 952
            ||.......:.|||.:::|:|.:..|.:.||:.|        |..|..:         ||..|:.
  Fly   485 IETARECFNIGNFNSLMAIIAGLNLAPIGRLKKTWAKVQSAKFSVLEHQMDPTSNFNSYRSTLKA 549

  Fly   953 CRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLANTELINFSKRRKVAEIIGE 1017
            ....|:.   ..:||.|.|    :|||..::.::..|.||..:.|.|.. |||.|..::|:.:.|
  Fly   550 AMWRSEG---ATEERERII----IPFFSLFVKDLYFLNEGCSNRLPNNH-INFEKCSQLAKQVME 606

  Fly  1018 IQQYQ--NQPY--------------CLNEESTIRQFFEQLDPFN 1045
            ..:::  |.|:              .|||.:.....||...|.|
  Fly   607 FNEWKKVNCPFERLPNVIAYLQNSAVLNENTLSMASFECEPPEN 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963	3/8 (38%)
		PH	482..587	CDD:278594	3/9 (33%)
		RasGEFN	637..791	CDD:214571	42/181 (23%)
		RasGEF	825..1062	CDD:238087	67/281 (24%)
CG7369	NP_649415.2	RasGEF_N	116..261	CDD:279012	36/152 (24%)
		RasGEF	388..649	CDD:214539	64/269 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940