DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sos and RASGRP3

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_001132960.1	Gene:	RASGRP3 / 25780	HGNCID:	14545	Length:	690	Species:	Homo sapiens

Alignment Length:	479	Identity:	97/479 - (20%)
Similarity:	185/479 - (38%)	Gaps:	104/479 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   642 KGAT----LCKLIERLTYHIYADPTFV-RTFLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQDTG 701
            |.||    ||..||....:...|.::: |..|..:|::.|..:|.:.|:..:
Human     8 KAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMY------------- 59

  Fly   702 TAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLEKLL 766
                            :|:..|....:|        .::...:|:|:.....:|..|..|:....
Human    60 ----------------RNATGESCNEFR--------LKICYFMRYWILKFPAEFNLDLGLIRMTE 100

  Fly   767 NFLEHVNGKSMRKWV-----------DSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPN 820
            .|.|..:.....|.|           |.:.::.|||...:|....:::         :|
Human   101 EFREVASQLGYEKHVSLIDISSIPSYDWMRRVTQRKKVSKKGKACLLF---------DH------ 150

  Fly   821 DEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEV------KSPNLLKIMKHTTN 879
                   |.|:|||..||.||.:.::.:.        :|.....|      .:|.|.:.:.....
Human   151 -------LEPIELAEHLTFLEHKSFRRIS--------FTDYQSYVIHGCLENNPTLERSIALFNG 200

  Fly   880 VTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPE 944
            :::|::..:......::|..::.:.|.|...:|:|.|||.::::|..:..:|:.||:.|...|..
Human   201 ISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSS 265

  Fly   945 RYRKFLEECREL--SDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLANTELINFSK 1007
            ...|...|..||  |:.:...|::.....:...:|..|.:|.:::.:....||.....: :|..|
Human   266 EVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENK-VNIVK 329

  Fly  1008 RRKVAEIIGEIQQYQNQPYCLNEE-STIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCK-- 1069
            ..:::..:.|:...||..:.|... ..|......||.::      ..|.:|..||.:|||..|
Human   330 MHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYH------TEDDIYKLSLVLEPRNSKSQ 388

  Fly  1070 -TVPKFPRKWPHIPLK-SPGIKPR 1091
             |.|..|.| |.:||: :.|:.|:
Human   389 PTSPTTPNK-PVVPLEWALGVMPK 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	28/164 (17%)
		RasGEF	825..1062	CDD:238087	51/245 (21%)
RASGRP3	NP_001132960.1	REM	11..126	CDD:100121	24/151 (16%)
		RasGEF	148..384	CDD:214539	55/272 (20%)
		EF-hand_7	428..478	CDD:316058
		C1	495..544	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810