DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sos and Ralgps1

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_780420.1	Gene:	Ralgps1 / 241308	MGIID:	1922008	Length:	585	Species:	Mus musculus

Alignment Length:	587	Identity:	124/587 - (21%)
Similarity:	218/587 - (37%)	Gaps:	198/587 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   825 LLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTRWIEKSIT 889
            :|.:.|.|.|.|:||::..::|.::|.||....|:||:|...:||::...:....|:.|:.:.|.
Mouse    46 VLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREIL 110

  Fly   890 EAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECR 954
            .|:..:.|..|:...:::...:|||||.:.::|:|:|:.:|.::||..|:..|..:.:...|:..
Mouse   111 TAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLD 175

  Fly   955 EL--SDDHLKKYQERLRSIN-PPCVPFFGRYLTNILHLEEGNP---DLLANTELINFSKRRKVAE 1013
            .|  .:|:.|:.::.:||:. .|.:|:.|.||.::::::...|   .::.|.:..|  :...:..
Mouse   176 YLMSKEDNYKRTRDYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIMENEQRSN--QMNNILR 238

  Fly  1014 IIGEIQ---QYQN---QPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVP 1072
            ||.::|   .|.:   .|:......::| :.|:|..|       :.|..|..||||||
Mouse   239 IIADLQVSCSYDHLTTLPHVQKYLKSVR-YIEELQKF-------VEDDNYKLSLRIEP------- 288

  Fly  1073 KFPRKWPHIPLKSPGIKPRRQNQTNSSSKLSNSTSSVAAAAAASSTATSIATASAPSLHASSIMD 1137
                                   .:||.:|.:|...:|..:|.||:|......:.|..
Mouse   289 -----------------------GSSSPRLVSSKEDLAGPSAGSSSARFRRRPTCPDT------- 323

  Fly  1138 APTAAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSWSGTPQHTRTDQNNGEVSVPAPH 1202
                        ::||                                           |:|.|.
Mouse   324 ------------SVAG-------------------------------------------SLPTPP 333

  Fly  1203 LPKKPGAHVWANN----NSTLASASAMDVVFSPALPEHLPPQSLPDSNPFASDTEAPPSPLPKLV 1263
            :|:...:|...||    .|.:.|.||   .|......||...|:.:|
Mouse   334 VPRHRKSHSLGNNLMCQLSVVESKSA---TFPSEKARHLLDDSVLES------------------ 377

  Fly  1264 VSPRHETGNRSPFHGRMQNSPTHSTASTVTLTGMSTSGGEEFCAGGFYFNSAHQGQPGAVPISPH 1328
                     |||..|.     || |:||....|:|....|                      |..
Mouse   378 ---------RSPRRGL-----TH-TSSTAITNGLSLGSSE----------------------SSE 405

  Fly  1329 VNVPMATNME-----YRAVPP--PLPPRRKERTESCADMAQKRQAPDAP---------TLPPRDG 1377
            .:..|:..:|     |..:.|  .:|.|...||.||.      .:|.:|         |:|..:|
Mouse   406 FSEEMSAGLESRGRLYATLGPNWRVPVRNSPRTRSCV------YSPTSPCTCTVGSSATVPTMEG 464

  Fly  1378 EL 1379
            .|
Mouse   465 PL 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571
		RasGEF	825..1062	CDD:238087	62/248 (25%)
Ralgps1	NP_780420.1	RasGEF	46..288	CDD:214539	65/251 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..342		16/114 (14%)
		PXXP	330..333		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..410		13/59 (22%)
		Required for stimulation of nucleotide exchange by RALA. /evidence=ECO:0000250	461..585		2/6 (33%)
		PH_RalGPS1_2	461..576	CDD:270120	2/6 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810