DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sos and Rasgrp3

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_001159965.1	Gene:	Rasgrp3 / 240168	MGIID:	3028579	Length:	691	Species:	Mus musculus

Alignment Length:	391	Identity:	79/391 - (20%)
Similarity:	158/391 - (40%)	Gaps:	69/391 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 HKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLEKLLNFLEHVNGKSMRKWV 781
            ::|:..|....:|        .::...:|:|:.....:|..|..|:.....|.|..:.....|.:
Mouse    59 YRNASGESCDEFR--------LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGHEKHI 115

  Fly   782 -----------DSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELAR 835
                       |.:.::.|||...::....:::         :|             |.|:|||.
Mouse   116 SLMDISSVPSYDWMRRVTQRKKVSKRGKACLLF---------DH-------------LEPIELAE 158

  Fly   836 QLTLLEFEMYKNVKPSELVGSPWTKKDKEV------KSPNLLKIMKHTTNVTRWIEKSITEAENY 894
            .||.||.:.::.:.        :|.....|      .:|.|.:.:.....:::|::..:....:.
Mouse   159 HLTFLEHKSFRRIS--------FTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSA 215

  Fly   895 EERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECREL--S 957
            ::|..::.:.|.|...:|:|.|||.::::|..:..:|:.||:.|...|.....|...|..||  |
Mouse   216 QQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSS 280

  Fly   958 DDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLLANTELINFSKRRKVAEIIGEIQQYQ 1022
            :.:...|::.....:...:|..|.:|.:::.:....||.:...: :|..|..:::..:.|:...|
Mouse   281 NGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENK-VNVVKMHQLSVTLSELVSLQ 344

  Fly  1023 NQPYCLNEE-STIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCK---TVPKFPRKWPHIPL 1083
            |..:.|... ..|......||.::      ..|.:|..||.:|||..|   |.|..|.| |.:||
Mouse   345 NASHHLEPNMDLINLLTLSLDLYH------TEDDIYKLSLVLEPRNSKSQPTSPTTPNK-PVVPL 402

  Fly  1084 K 1084
            :
Mouse   403 E 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	13/84 (15%)
		RasGEF	825..1062	CDD:238087	51/245 (21%)
Rasgrp3	NP_001159965.1	REM	11..126	CDD:100121	11/74 (15%)
		RasGEF	148..384	CDD:214539	55/272 (20%)
		EF-hand_7	428..478	CDD:372618
		C1	495..544	CDD:237996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810