DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sos and RASGEF1A

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_001269791.1	Gene:	RASGEF1A / 221002	HGNCID:	24246	Length:	489	Species:	Homo sapiens

Alignment Length:	489	Identity:	104/489 - (21%)
Similarity:	187/489 - (38%)	Gaps:	128/489 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   624 SGDNIVLEERESAGVPMIKGATLCKLIERL--TYHIYADPTFVRTFLTTYRYFCSPQQLL----Q 682
            |||.|..:..      :|.| :|..|:|.|  |...|.|.|::.|||.:.|.|..|..||    |
Human    43 SGDLIFQDGH------LISG-SLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQ 100

  Fly   683 LLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHW 747
            :.||:                           |:...:..|      |..::....:::.:|:.|
Human   101 ICVEQ---------------------------KQQLEAGPE------KAKLKSFSAKIVQLLKEW 132

  Fly   748 VDHHFYDFEKDPMLLEKLLNFLEH-------VNG---KSMRKWVDSVLKIVQRKNEQEKSNKKIV 802
            .:...|||:.:..:.|  |..:.|       .||   |::.:...|:|..:..:::.::..:|:
Human   133 TEAFPYDFQDEKAMAE--LKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQELREKL- 194

  Fly   803 YAYGHDPPPIEH------HLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSEL--VGSPWT 859
                 .||.::.      .......:|..:...||.||:|||.:|.:...::.|.:|  :.|...
Human   195 -----RPPAVDKGPILKTKPPAAQKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLMQIVSHMD 254

  Fly   860 KKDKEVKSPNLLKI--------------MKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMV 910
            ..|......:|.|.              |...|.|.|.::|        :.|..:::..|:|...
Human   255 SLDNHRCRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKK--------KHRTRMLEFFIDVARE 311

  Fly   911 MLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECRELSDDH------LKKYQERLR 969
            ...:.|||.:::|::.|..:.|.||:.|:..:.......||...:.|.:.      |:...:|.:
Human   312 CFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQ 376

  Fly   970 SINPP----CVPFFGRYLTNILHLEEGNPDLLANTELINFSKRRKVAEIIGEIQQYQNQPYCLNE 1030
            ..|..    .:|.|..::.:|..|.:.:.:.|.|.. |||.|..:::..|.|...: .|..|
Human   377 MANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGH-INFKKFWEISRQIHEFMTW-TQVEC--- 436

  Fly  1031 ESTIRQFFEQLDPFNGLSDKQMSDYL-----YNE 1059
                        ||.  .||::..||     |:|
Human   437 ------------PFE--KDKKIQSYLLTAPIYSE 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	37/169 (22%)
		RasGEF	825..1062	CDD:238087	59/266 (22%)
RASGEF1A	NP_001269791.1	REM	57..184	CDD:100121	35/161 (22%)
RASGEF1A	NP_001269791.1	RasGEF	222..470	CDD:214539	59/262 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910