DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sos and Sos2

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	XP_006515698.1	Gene:	Sos2 / 20663	MGIID:	98355	Length:	1333	Species:	Mus musculus

Alignment Length:	1395	Identity:	608/1395 - (43%)
Similarity:	836/1395 - (59%)	Gaps:	150/1395 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 YDFTKCENAARWRGLFTPSLKKVLEQVHPRVTAKEDALLYVEKLCLRLLAMLCAKPLPHSVQDVE 122
            |:|...||:.:||||..|:|:||.|||||.::|.|::|.|:|:|..:||..||... |.:|||||
Mouse     8 YEFFSEENSPKWRGLLVPALRKVQEQVHPTLSANEESLYYIEELIFQLLNKLCMAQ-PRTVQDVE 71

  Fly   123 EKVNKSFPAPIDQWALNEAKEVINSKKRKS--VLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVLE 185
            |:|.|:||.|||:||:.:|:..|..:||::  :||.:|:|..| |:||.||:|..||.::|||||
Mouse    72 ERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSL-KEVLGYKVDYHVSLYIVAVLE 135

  Fly   186 YISADILKMAGDYVIKIAHCEITKEDIEVVMNADRVLMDMLNQSEAHILPSPLSL----PAQRAS 246
            ||||||||:||:||..|.|.||:::||:|.|.||:|||||.:|.:...|   :||    |.....
Mouse   136 YISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDDDIGL---VSLCEDEPCSSGE 197

  Fly   247 ATYEETVKELIHDEKQYQRDLHMIIRVFREE--LVKIVSDPRELEPIFSNIMDIYEVTVTLLGSL 309
            ..|.:.|:..|.:|:||.|:|:|||:||||.  |.:.:..|.|:|.|||||.||:|:||.|||.:
Mouse   198 LNYYDLVRTEIAEERQYLRELNMIIKVFREAFLLDRKLFKPSEIEKIFSNISDIHELTVKLLGLI 262

  Fly   310 EDVIEMSQEQSA-PCVGSCFEELAEAEEFDVYKKYAYDVTSQASRDALNNLLSKPG-ASSLTTAG 372
            ||.:||:.|.|. |..|||||:|||.:.||.|:..:.|:.:....|..:.|:::|. |....:..
Mouse   263 EDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDILAPEFNDHFSKLMARPAVALHFQSIA 327

  Fly   373 HGFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMAS 437
            .||::||:|.||:|:|||:.|.:.||:.:|.||..|..|:|.|...|....|..|...::::...
Mouse   328 DGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDKECLNQAITALMNLQGSMDRIYKQ 392

  Fly   438 LSKERQV--PVSGRVRRQ-----LAIERTRELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSGKR 495
            .|..|:.  ||.....||     |||::..|:|..::.||.||:||.|||||.|..|:::|:.
Mouse   393 HSPRRRPGDPVCLFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAK-- 455

  Fly   496 IWSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPDSDDLKNSFELAP 560
              .||.:|||||||:.||.| ..||...|.::.:||||||:.||::.|.|:.|:.:.:::|||..
Mouse   456 --HERHIFLFDGLMISCKPN-HGQTRLPGYSSAEYRLKEKFVMRKIQICDKEDACEYRHAFELVS 517

  Fly   561 RMQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPEIYKFAVPDSG 625
            :.:..::..||:|:.|::|||.|:.:..:|.|||.|||:|...|.:.|||:|||::|:|.|.||.
Mouse   518 KDENSVIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENEQPLRLPSPDMYRFVVTDSE 582

  Fly   626 DNIVLEE--RESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQLLVERF 688
            :|||.|:  :..:|:|:|||.|:.|||||||||:||||.||||||||||.||.||:||.||:|||
Mouse   583 ENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLNLLIERF 647

  Fly   689 NIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFY 753
            .||:|.....|......|           :.....|.||:|||||||||.|||||.||||:||:|
Mouse   648 EIPEPEPTEADKLALEKG-----------EQPISADLKRFRKEYVQPVQLRVLNVFRHWVEHHYY 701

  Fly   754 DFEKDPMLLEKLLNFLEHVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSV 818
            |||:|..|||:|.:|:..|.||:|:|||:|:.||::||.:.:.:.......:...|||:|.|:|.
Mouse   702 DFERDLELLERLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESSPPPVEWHISR 766

  Fly   819 PN--DEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVT 881
            ..  :...|:||||:|:||||||||.::|:.|:|||||||.|||:|||:.||||||:::||||:|
Mouse   767 TGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLT 831

  Fly   882 RWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERY 946
            .|.||.|.||||:|||:|::.|.:|::.|..:||||||:|.||:|:.:.|||||..||:.|.||.
Mouse   832 LWFEKCIVEAENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERK 896

  Fly   947 RKFLEECRELSDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLL--ANTELINFSKRR 1009
            |:.|::..|||.||.|||..:|:|||||||||||.||||||..||||.|.|  ...:||||||||
Mouse   897 RRILDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKRR 961

  Fly  1010 KVAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKF 1074
            |||||.|||||||||||||..|..:|:|||.|:|...||:|:.:|||:|:||.||||.||..|:|
Mouse   962 KVAEITGEIQQYQNQPYCLRTEPEMRRFFENLNPMGILSEKEFTDYLFNKSLEIEPRNCKQPPRF 1026

  Fly  1075 PRKWPHIPLKSPGIKPRRQNQTNSSSKLSN------------STSSVAAAAAAS--STATSIATA 1125
            ||| ....||||||:|......::|..|..            |.|.:|.....|  |..||..|.
Mouse  1027 PRK-STFSLKSPGIRPNAGRHGSTSGTLRGHPTPLEREPYKISFSRIAETELESTVSAPTSPNTP 1090

  Fly  1126 SAPSLHASS----IMDAPTAAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSWSGTPQH 1186
            |.|.:.|||    .:|..  ..::.||.|               :||||::|...|...|....|
Mouse  1091 STPPVSASSDHSVFLDVD--LNSSCGSNT---------------IFAPVLLPHSKTFFSSCGSLH 1138

  Fly  1187 TRTDQNNGEVSVPAPHLPKKPGAHVWANNNSTLASASAMDVVFSPALPEHLPPQSLPDSNP---- 1247
            ..::    |..:|.|..|:|...|...|:...:.|...     .||:|...||.  |...|
Mouse  1139 KLSE----EPLIPPPLPPRKKFDHDALNSKGAVKSDDD-----PPAIPPRQPPP--PKVKPRVPV 1192

  Fly  1248 ----FASDTEAPPSPLPKLVVSPRHETGN----RSPFH-----GRMQNSPT-HSTASTVTLTGMS 1298
                |.....:||.|.|:   .|..:|..    |.|.|     ..:|..|. |.......|..:|
Mouse  1193 LMGTFDGPVPSPPPPPPR---DPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHPHRDPDWLRDVS 1254

  Fly  1299 TSGGEEFCAGGFYFNSAHQGQPGAVPISPHVNVPMATNM------EYRAVP-PPLPPRRKERTES 1356
            |      |.     ||     |...|.:|...:|.:.::      ....:| ||:|||
Mouse  1255 T------CP-----NS-----PSTPPTTPSPRIPRSCHLLSSSHSSLAHLPAPPVPPR------- 1296

  Fly  1357 CADMAQKRQAPDAPTLPPR--DGELSPPPI 1384
                  :..:|..|.|||:  ..|||.||:
Mouse  1297 ------QNSSPLLPKLPPKTYKRELSHPPL 1320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551	67/127 (53%)
		H2A	155..>196	CDD:305064	25/40 (63%)
		RhoGEF	249..432	CDD:238091	79/186 (42%)
		PH_SOS	476..586	CDD:269963	46/109 (42%)
		PH	482..587	CDD:278594	41/104 (39%)
		RasGEFN	637..791	CDD:214571	88/153 (58%)
		RasGEF	825..1062	CDD:238087	150/238 (63%)
Sos2	XP_006515698.1	Histone	70..169	CDD:333859	54/99 (55%)
		RhoGEF	200..387	CDD:238091	79/186 (42%)
		PH_SOS	438..544	CDD:269963	46/110 (42%)
		RasGEFN	596..740	CDD:214571	89/154 (58%)
		RasGEF	775..1019	CDD:214539	154/243 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I2269
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1027	1.000	Inparanoid score	I277
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45786
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002651
OrthoInspector	1	1.000	-	-		otm44267
orthoMCL	1	0.900	-	-		OOG6_101209
Panther	1	1.100	-	-	LDO	PTHR23113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	1	1.000	-	-		X2024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860