DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sos and Rgl2

DIOPT Version :10

Sequence 1:NP_476597.2 Gene:Sos / 34790 FlyBaseID:FBgn0001965 Length:1596 Species:Drosophila melanogaster
Sequence 2:NP_033085.2 Gene:Rgl2 / 19732 MGIID:107483 Length:778 Species:Mus musculus


Alignment Length:828 Identity:178/828 - (21%)
Similarity:282/828 - (34%) Gaps:263/828 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   650 IERLTYHIY------ADPTFVRTFLTTYRYFCSPQQLLQLLVERFNIPD---PSLVYQDTGTAGA 705
            :|.|..|:.      ||..|....|.|:|.|.|...|..|:.:|....:   |..:.:.||.|  
Mouse    97 LEALVRHLLDARTAGADMMFTPALLATHRAFTSTPALFGLVADRLEALESHPPGELERTTGVA-- 159

  Fly   706 GGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPM-LLEKLLNFL 769
                                               ::||..|:..|..||..:.. .|::|.:||
Mouse   160 -----------------------------------ISVLSTWLASHPEDFGSEVKGQLDRLESFL 189

  Fly   770 --------EHVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLL 826
                    |.|.|.|    .|.:..:..|.:.:.....|.:...|..|       :.|.|.:..|
Mouse   190 LRTGYAAREGVVGGS----ADLIRNLRARVDPRAPDLPKPLALPGDSP-------ADPTDVLVFL 243

  Fly   827 TLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKS---PNLLKIMKHTTNVTRWIEKSI 888
            ..|   ||.|||||:.|::.|:.||:.:|..|..:|:...|   |::...:.....|...:..|:
Mouse   244 ADH---LAEQLTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSV 305

  Fly   889 TEAENYEE--------------RLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLR--W 937
            ..|.:..|              |..::::.|.|......|.||:.:.::|:|:.::.::|||  |
Mouse   306 LGATSIGEGPREVTVRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAW 370

  Fly   938 TFQGLPERYRKFLEECRELS-DDHLKKYQERLR---SINPP-----------------CVPFFGR 981
            . :...:..|.|...|:..| :|:..:.:|.|.   ...||                 .||:.|.
Mouse   371 G-ETTRDSLRVFSSLCQIFSEEDNYSQSRELLMQEVKPQPPVEPHSKKAPRSGFRGGGVVPYLGT 434

  Fly   982 YLTNILHLEEGNPDLLANTELINFSKRRKVAEIIGEIQQYQNQ--PYCLNEESTIRQFFEQLDPF 1044
            :|.:::.|:..:.|.|.| ..|||.||||...|:.|:.:.|.:  .|.|...|.|:|:.:.|.| 
Mouse   435 FLKDLVMLDAASKDELEN-GYINFDKRRKEFAILSELLRLQKECRGYDLRPNSDIQQWLQGLQP- 497

  Fly  1045 NGLSDKQMSDYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQTNSSSKLSNSTSSV 1109
              |::.|.    :..|..:||.|....|                                     
Mouse   498 --LTEAQS----HRVSCEVEPPGTSDSP------------------------------------- 519

  Fly  1110 AAAAAASSTATSIATASAPSLHASSIMDAPTAAAANAGSGTLAGEQSPQHNPHAFSVFAPVIIPE 1174
               ||.:...|.:.|.....|                  |::.|.             .|::   
Mouse   520 ---AARTPRPTLVITQWTEVL------------------GSVGGP-------------TPLV--- 547

  Fly  1175 RNTSSWSGTPQHTRTDQNNGEV-SVPAPHLPKKPGAHVWANNNSTLASASAMDVVFSPALPEHLP 1238
                ||.      |......|| ..|||.|.:......|.:.:|..::..:...:.|||.|.||.
Mouse   548 ----SWD------RPSVGGDEVPGTPAPLLTRLAQHMKWPSVSSLDSALESSPSLHSPADPGHLS 602

  Fly  1239 PQSLPDSNPFASDTEAPPSPLPKLVVSPRHETGNRSPFHGRMQNSPTHSTASTVTLTGMSTSGGE 1303
            |               |.|       |||       |..|..:::...|..|..|..|.|.|.| 
Mouse   603 P---------------PAS-------SPR-------PSRGHRRSASCGSPLSGNTGEGTSRSAG- 637

  Fly  1304 EFCAGGFYFNSAHQGQPGAVPISPHVNVPMATNMEYRAVPPPLPPRRKERTESCADMAQKRQAPD 1368
              |.||.       ..||:.... .:.|.|... |..:|...:....:::..|......|:...|
Mouse   638 --CGGGV-------SGPGSSDCR-IIRVQMELG-EDGSVYKSILVTSQDKAPSVISRVLKKNNRD 691

  Fly  1369 APT--------LPPRDGELSPPPIPPRLNHSTGISYLRQSHGKSKEFV 1408
            :..        |.|.|.||:.|       ||..:.|...  |.|.:|:
Mouse   692 SAVASEFELVQLLPGDRELTIP-------HSANVFYAMD--GASHDFL 730

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SosNP_476597.2 HFD_SOS1_rpt1 68..145 CDD:467039
HFD_SOS1_rpt2 153..227 CDD:467040
RhoGEF 249..432 CDD:238091
PH_SOS 476..586 CDD:269963
RasGEFN 637..791 CDD:214571 33/158 (21%)
RasGEF 825..1062 CDD:238087 71/278 (26%)
PHA03247 <1197..1502 CDD:223021 51/220 (23%)
Rgl2NP_033085.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59
RasGEFN 90..212 CDD:214571 33/155 (21%)
RasGEF 239..513 CDD:214539 72/285 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 503..524 7/64 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 541..564 7/48 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 581..647 26/104 (25%)
RA_RGL2 649..734 CDD:340731 19/93 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 735..769
Blue background indicates that the domain is not in the aligned region.

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