DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sos and Rasgrp1

DIOPT Version :9

Sequence 1:NP_476597.2 Gene:Sos / 34790 FlyBaseID:FBgn0001965 Length:1596 Species:Drosophila melanogaster
Sequence 2:NP_035376.1 Gene:Rasgrp1 / 19419 MGIID:1314635 Length:795 Species:Mus musculus


Alignment Length:496 Identity:107/496 - (21%)
Similarity:184/496 - (37%) Gaps:120/496 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   640 MIKGATLCKLIERLTYHIYADPTFVR------TFLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQ 698
            :.|||:|..||:.......||....|      ..||.:|...|..:|||.::..:.         
Mouse    56 LAKGASLDDLIDSCIQSFDADGNLCRNNQLLQVMLTMHRIIISSAELLQKVMNLYK--------- 111

  Fly   699 DTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLE 763
                           |...|||             ..|..::...:|:|:...:..|:.|..|..
Mouse   112 ---------------DALEKNS-------------PGVCLKICYFVRYWITEFWIMFKMDASLTS 148

  Fly   764 KLLNF--LEHVNGK------------SMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEH 814
            .:..|  |...||:            :.|.|   ..|:.||........:|:...:.|       
Mouse   149 TMEEFQDLVKANGEETHCHLIDTTQINSRDW---SRKLTQRIKSNTSKKRKVSLLFDH------- 203

  Fly   815 HLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSE----LVGSPWTKKDKEVK-SPNLLKIM 874
                         |.|.||:..||.|||:.::.:..|:    ||.|.       || :|.:.:.:
Mouse   204 -------------LEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSC-------VKENPTMERSI 248

  Fly   875 KHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTF 939
            .....:::|::..:......:.|..:..:.|.|...:.:|.|||.:::::..:..:|:.||:.|.
Mouse   249 ALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETS 313

  Fly   940 QGLPERYRKFLEECREL------SDDHLKKYQERLRSINPPC----VPFFGRYLTNILHLEEGNP 994
            ..:|....|.|.|..||      .|::.:.|.|        |    :|..|.:|.:::.|.|..|
Mouse   314 SHVPHEINKVLGEMTELLSSCRNYDNYRRAYGE--------CTHFKIPILGVHLKDLISLYEAMP 370

  Fly   995 DLLANTELINFSKRRKVAEIIGEIQQYQNQ--PYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLY 1057
            |.|.:.: :|..|...:...|.|:.|.|..  |...|:: .:......||.:      ...|.:|
Mouse   371 DYLEDGK-VNVQKLLALYNHINELVQLQEMAPPLDANKD-LVHLLTLSLDLY------YTEDEIY 427

  Fly  1058 NESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQTNS 1098
            ..|...|||..:..|..|.|.|.:...:.|:.|:...:|.|
Mouse   428 ELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTIS 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SosNP_476597.2 Histone 90..216 CDD:278551
H2A 155..>196 CDD:305064
RhoGEF 249..432 CDD:238091
PH_SOS 476..586 CDD:269963
PH 482..587 CDD:278594
RasGEFN 637..791 CDD:214571 34/170 (20%)
RasGEF 825..1062 CDD:238087 59/253 (23%)
Rasgrp1NP_035376.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
RasGEFN 54..176 CDD:214571 30/156 (19%)
Ras exchanger motif region, required for transforming activity 57..110 16/52 (31%)
RasGEF 201..437 CDD:214539 62/278 (22%)
EFh 474..521 CDD:238008
EF-hand_7 478..526 CDD:290234
C1_1 542..591 CDD:278556
Suppress the PT region-mediated translocation to plasma membrane 686..694
PT region, mediates the BCR-dependent translocation to plasma membrane 717..795
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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