DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sos and Rasgrp2

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_035372.2	Gene:	Rasgrp2 / 19395	MGIID:	1333849	Length:	608	Species:	Mus musculus

Alignment Length:	462	Identity:	96/462 - (20%)
Similarity:	179/462 - (38%)	Gaps:	106/462 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   660 DPTFVRTFLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHRED 724
            ||..||.||..:.::....||...|:.         .||.:
Mouse    32 DPQLVRMFLMMHPWYIPSSQLASKLLH---------FYQQS------------------------ 63

  Fly   725 WKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLEKLLNFLEHVNGKSMRKW-----VDSV 784
                ||:....:|.:..:::|:|:.....:|:.:|.|.|::......::.:..|:.     ::||
Mouse    64 ----RKDNSNSLQMKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIESV 124

  Fly   785 -----LKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEM 844
                 .:.|.::|..|:..:|:...:.|                    |.|:|||..||.||:..
Mouse   125 PTYKWKRQVTQRNPVEQKKRKMSLLFDH--------------------LEPMELAEHLTYLEYRS 169

  Fly   845 YKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMM 909
            :..:...:.  ..:......|.:|.|.:.:....:|::|::..|.......:|..::...:.|..
Mouse   170 FCKILFQDY--HSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTATQRALVITHFVHVAE 232

  Fly   910 VMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECREL--SDDHLKKYQERLRSIN 972
            .:|:|.|||.::::|..:..:|:.||:.|...:.....|..|...||  :..:...|:.||.:
Mouse   233 RLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPDTIKLWEGLTELVTATGNYSNYRRRLAA-- 295

  Fly   973 PPCV----PFFGRYLTNILHLEEGNPDLL--ANTELINFSKRRKVAEIIGEIQQYQN-QPYCLNE 1030
              ||    |..|.:|.:::.|:...||.|  ..|.| |.:|.|::..|:.|:....: :|.....
Mouse   296 --CVGFRFPILGVHLKDLVALQLALPDWLDPGRTRL-NGAKMRQLFCILEELAMVTSLRPPVQAN 357

  Fly  1031 ESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPR---------GCKTVPKFP--RKWPHIPLK 1084
            ...:......||.:      |..|.||..||:.|||         .|...|:.|  .:|..:
Mouse   358 PDLLSLLTVSLDQY------QTEDELYQLSLQREPRSKSSPTSPTSCTPPPRPPVLEEWTSV--- 413

  Fly  1085 SPGIKPR 1091
               .||:
Mouse   414 ---AKPK 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	24/140 (17%)
		RasGEF	825..1062	CDD:238087	58/245 (24%)
Rasgrp2	NP_035372.2	RasGEFN	7..121	CDD:214571	21/125 (17%)
		RasGEF	150..387	CDD:214539	61/269 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..405		6/22 (27%)
		EFh	430..481	CDD:238008
		C1	499..548	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810