DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sos and rgef-1

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_505469.3	Gene:	rgef-1 / 179344	WormBaseID:	WBGene00009100	Length:	654	Species:	Caenorhabditis elegans

Alignment Length:	426	Identity:	86/426 - (20%)
Similarity:	168/426 - (39%)	Gaps:	103/426 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   740 VLNVLRHWVDHHFYDFEKDPML---LEKLLNFLEHVNGKSMRKWVD-------SVLKIVQRKNEQ 794
            |...:..|::.....|:..|.:   :.:|....|.:| :::|..:|       :.|:.|..:|..
Worm    77 VCRAVSFWIEKFPMHFDAQPQVCAQVVRLKTIAEDIN-ENIRNGLDVSALPSFAWLRAVSVRNPL 140

  Fly   795 EKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWT 859
            .|..     |:                .::.:...|.:::..|:.:::.:...:..:||   ...
Worm   141 AKQT-----AF----------------SLSFVQASPSDISTSLSHIDYRVLSRISITEL---KQY 181

  Fly   860 KKDKEVKS-PNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSI 923
            .||..::| |.|.:.:....|::.|::..|......:||..|:.:.:.|...:.::||||.::|:
Worm   182 VKDGHLRSCPMLERSISVFNNLSNWVQCMILNKTTPKERAEILVKFVHVAKHLRKINNFNTLMSV 246

  Fly   924 VAAMGTASVYRLRWTFQGLPERYRKFLEECREL--SDDHLKKYQERLRSINPPC-VPFFGRYLTN 985
            |..:..:||.||..|:..|....:|.|.:...|  :..:..:|::.|.:.|... :|..|
Worm   247 VGGITHSSVARLAKTYAVLSNDIKKELTQLTNLLSAQHNFCEYRKALGACNKKFRIPIIG----- 306

  Fly   986 ILHLEEGNPDLLA-NTELINFSKRR--------KVAEIIGEIQQYQNQPYCLNEESTIRQFFEQL 1041
             :||:    ||:| |....||.|.:        |:::::.....:..:.:.|.|.:        :
Worm   307 -VHLK----DLVAINCSGANFEKTKCISSDKLVKLSKLLSNFLVFNQKGHNLPEMN--------M 358

  Fly  1042 DPFN----GLSDKQMSDYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQTNSSSKL 1102
            |..|    .|..:...|.:|..|||.||   ||...|              :|.|
Worm   359 DLINTLKVSLDIRYNDDDIYELSLRREP---KTFMNF--------------EPSR---------- 396

  Fly  1103 SNSTSSVAAAAAASSTATSIATASAPSLHASSIMDA 1138
                 .:..|..||....:...|:. |.|.|:::||
Worm   397 -----GLVFAEWASGVTVAPDNATV-SKHISAMVDA 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	11/60 (18%)
		RasGEF	825..1062	CDD:238087	54/253 (21%)
rgef-1	NP_505469.3	RasGEF	150..388	CDD:214539	58/261 (22%)
		EFh	423..473	CDD:238008	2/4 (50%)
		EF-hand_7	427..477	CDD:290234	86/426 (20%)
		C1	493..542	CDD:237996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910