DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sos and pxf-1

DIOPT Version :9

Sequence 1:NP_476597.2 Gene:Sos / 34790 FlyBaseID:FBgn0001965 Length:1596 Species:Drosophila melanogaster
Sequence 2:NP_001023389.1 Gene:pxf-1 / 177894 WormBaseID:WBGene00004254 Length:1470 Species:Caenorhabditis elegans


Alignment Length:1542 Identity:286/1542 - (18%)
Similarity:511/1542 - (33%) Gaps:527/1542 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 SYGG----GI-------GLGTGGGGGSGGSGSGSQGGGGGIGIG--------GGGVAGLQDCDGY 58
            |.||    ||       |..|.....:.|..:.::|.......|        .||...|:|    
 Worm   257 SVGGQAQNGISTARRLRGRSTASSTTTEGETASNEGADSDEDEGSMPSQESSSGGFMDLRD---- 317

  Fly    59 DFTKCENAARWRGLFTPSLKKVLEQVHPRVTAKEDALLYVE---------KLCLRLLAMLCAKPL 114
                             |:::.||: .|.....||..:.::         .|.:.:...||.|.:
 Worm   318 -----------------SVRECLEK-EPSERNSEDLAVLLDFMQHMSAFAALPMSIKRQLCLKMV 364

  Fly   115 PHSVQDVEEKV---NKSFPAPIDQWA--LNEAKEVINSKKRKSVLPTEKVHTLLQKDVLQYKIDS 174
            ...|.|....|   |:.    :|.|:  :|...||:.....:                ::||:..
 Worm   365 FAVVNDAGTVVLAHNEK----LDSWSVIVNGCVEVVKPSGER----------------VEYKLGD 409

  Fly   175 SVSAFLVAVLEYISADILKMAGDYVIKIAHCEITKEDIEVVMNADRVLMDMLNQSEAHILPSPLS 239
            |..|......:              |.|.......:|.|.|:...|....:::....||......
 Worm   410 SFGAEPTPATQ--------------IHIGEMRTMVDDCEFVLVEHRDFCSIMSTIGDHIEKDRDG 460

  Fly   240 LPAQRASATYEETV-------------KELIH---DEKQYQRDLHMI------IRVFREELVKIV 282
            |..:..|.....||             .:|||   ||:.:..|.|.:      .|||       :
 Worm   461 LTGEVVSEVERRTVGTHCGQVLIKGKPDKLIHHLVDERDHNVDPHYVDDFLLTYRVF-------I 518

  Fly   283 SDPRELEPIFSNIM-----DIYEVTVTLLGSLEDVIEMSQEQSAPCVGSCFEELAEAEE-FDVYK 341
            .||   ..||..:|     .||...|..|..|             .|.:.|.:....:| :::.:
 Worm   519 RDP---TTIFEKLMLWFADSIYRDKVARLVLL-------------WVNNHFNDFETNDEMWNLLE 567

  Fly   342 KYAYDVTSQASRDALNNLLS----------KPGASSLTTAGHGFRDAVKYYLPKLLL-------- 388
            ::    .....||.:::.||          ||....||..    :|      .|:::        
 Worm   568 RF----EGALERDGMHSQLSLLNIACSVKAKPRQVILTRR----KD------DKMMMRLVGGQES 618

  Fly   389 ---VPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMASLSKERQVPVSGRV 450
               |.:...|         .|.|::::.::..:::      |..:.:......:|:.:..::|.:
 Worm   619 GNSVYVAEVF---------PDTSAAREGVKRADEM------LEVNQQSAKYLSAKKAEDLLTGSL 668

  Fly   451 RRQLAIERT----RELQMKVEHWEDKDVGQNCNEFIREDSLSKLGSG---------------KRI 496
            ...|.::..    :|...|:||.:.|            :..|:.|:|               |..
 Worm   669 SLTLMLKNNVLGYKETIGKIEHNKPK------------NGTSRSGAGIPMVIPVHKTSITGKKSS 721

  Fly   497 WSERKVFLFDGLMVLCKANTKKQTPSAGATAYDYRLKEKYFMRRVDINDRPD-SDDLK-NSFELA 559
            .:..|..:.:.||.:.|::                 ||          |..| :|:.| :|.:|.
 Worm   722 TTSSKSGMMEKLMTILKSS-----------------KE----------DSMDFTDEAKISSADLR 759

  Fly   560 P-RMQPPIVLTAKNAQHKHDWMADLLMVITKSMLDRHLDSILQDIERKHPLRMPSPE----IYKF 619
            | |..|.|.                              ||.|   ...|:|...||    ||: 
 Worm   760 PSRSNPDIT------------------------------SISQ---YYGPVRSECPEHVLKIYR- 790

  Fly   620 AVPDSGDNIVLEERESAGVPMIKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQLL 684
                                                   .|.||  .:|..|:. .|.|.::||.
 Worm   791 ---------------------------------------NDQTF--KYLPVYKE-TSAQNVVQLA 813

  Fly   685 VERFNI-----PDPSLVYQDTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVL 744
            ::.||:     |:.||. :.|.|     :.||                 .|:...|.|...| ..
 Worm   814 LQEFNMTAEGSPEWSLC-ECTVT-----IDGV-----------------IKQRRLPPQMENL-AE 854

  Fly   745 RHWVDHHFY---DFEKDPMLLEKLLNFLEHVNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYG 806
            |..::..:|   :...:|::.::|               ...:||..|.:               
 Worm   855 RIALNSRYYLKNNSRSEPLVPDEL---------------APELLKEAQTQ--------------- 889

  Fly   807 HDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLL 871
                              ||:|:...:|.||||.:|.::..::|:|.:.:.: |.|.:..||.|.
 Worm   890 ------------------LLSLNAQVVAAQLTLQDFSVFSAIEPTEFLDNLF-KLDSKYGSPKLE 935

  Fly   872 KIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLR 936
            :..:.......|:...|....:.::|..::::.|:|.....:|.|||.:.:|::.:...:|.||.
 Worm   936 EFEQLFNREMWWVATEICTERHVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLH 1000

  Fly   937 WTFQGLPERYRKFLEECRELSDD--HLKKYQERLRSI--NPPCVPFFGRYLTNILHLEEGNPDLL 997
            .:::.:..:|.:.|:|..:|.|.  ::.||::.|..:  .||.||.:.....::....:||... 
 Worm  1001 SSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDGNATY- 1064

  Fly   998 ANTELINFSKRRKVAEIIGEIQQYQNQPY---CLNEES--TIRQFFEQLDPF---------NGLS 1048
             :.:||||.|.|.:|:.|..:.:..:.||   .:.|.|  .:......::.|         .|:|
 Worm  1065 -SEKLINFEKLRLIAKSIRGVMKLSSAPYEIASMAERSGGVVMDALLHMNSFENSNVATMRKGMS 1128

  Fly  1049 DKQMS--DYLYNESLRIEP-----RGCKTVPKFPRKWPHIPLKSPG--IKPRRQNQTNSSSKLSN 1104
            .||..  ..:|.::|.:..     .|...|..      .:.|.|..  |:|    |..::.:.:|
 Worm  1129 GKQNQPRKKVYEQALMVRKVKSYLEGLHVVDN------EMELDSMSYDIEP----QVQTAHRGAN 1183

  Fly  1105 STSSVAAAAAASSTATSIATASAPSLHASS---IMDAPTAAAANAGSGTLAGEQSPQHNPHAFSV 1166
            |:|:.......|.|.:|:::.||.|...||   ::...|.:.::||.|:..|.:|||......|:
 Worm  1184 SSSTANIRRVPSPTPSSLSSQSAGSADQSSRHRLLFNGTGSISSAGGGSKFGVESPQAVQKMLSL 1248

  Fly  1167 FAPVIIPERNTSSWSGTPQHTRTDQNNGEVSVPAPHLPKKPGAHVWANNNSTLASASAMDVVFSP 1231
            .        ..|...|.|....:...:...|:.. ::|:..|..         |::||..     
 Worm  1249 V--------QNSKVKGAPPQITSPSTSARSSLQR-NMPRVTGRQ---------ATSSAQG----- 1290

  Fly  1232 ALPEHLPPQSLPDSNPFASDT-------------EAPPSPL----PKLVVSPRHETGNRSPF--H 1277
              |..|..::...:..:.||.             ..|||..    ..|.||||.......|.  |
 Worm  1291 --PVQLNEETSTVTTYYQSDNGRRQRSGSEGRFDNIPPSTFYLTSDGLTVSPRQSLSVVIPTHPH 1353

  Fly  1278 GRMQNSP-------------THSTASTVTLTGMSTSGGEEFCAGGFYFNSAHQGQPGAVPISPHV 1329
            |....||             :.||.:::..|.|:.:      ...|..|.....|.....:..|.
 Worm  1354 GHSPTSPRCRSRSPASSGCSSFSTIASIAATSMAAA------PSAFVSNPYQHHQTVRGHVIGHR 1412

  Fly  1330 NVPMATN----MEYRAVPPPLPPRRK------ERTESCADMAQKRQA 1366
            .:|:.|:    :.....|..|||:.:      ..|.|.:.|...::|
 Worm  1413 PMPIVTSGSATLPNHVSPRGLPPKSRPTILPGSHTNSSSRMGTIKEA 1459

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SosNP_476597.2 Histone 90..216 CDD:278551 23/139 (17%)
H2A 155..>196 CDD:305064 4/40 (10%)
RhoGEF 249..432 CDD:238091 40/231 (17%)
PH_SOS 476..586 CDD:269963 20/127 (16%)
PH 482..587 CDD:278594 20/122 (16%)
RasGEFN 637..791 CDD:214571 29/161 (18%)
RasGEF 825..1062 CDD:238087 61/256 (24%)
pxf-1NP_001023389.1 CAP_ED 45..131 CDD:237999
cNMP 348..458 CDD:197516 25/143 (17%)
RasGEFN 479..592 CDD:214571 27/139 (19%)
PDZ_signaling 595..662 CDD:238492 11/91 (12%)
PDZ_GEF_RA 782..867 CDD:176380 28/151 (19%)
RasGEF 890..1118 CDD:238087 56/230 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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