DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sos and RASGRP2

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	XP_016872571.1	Gene:	RASGRP2 / 10235	HGNCID:	9879	Length:	898	Species:	Homo sapiens

Alignment Length:	396	Identity:	86/396 - (21%)
Similarity:	169/396 - (42%)	Gaps:	59/396 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   725 WKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLEKLLNFLEHVNGKSMRKW-----VDSV 784
            :::.||:....:|.:..:::|:|:.....:|:.:|.|.|::......::.:..|:.     :|||
Human   348 YQQSRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDIDSV 412

  Fly   785 -----LKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEM 844
                 .:.|.::|...:..:|:...:.|                    |.|:|||..||.||:..
Human   413 PTYKWKRQVTQRNPVGQKKRKMSLLFDH--------------------LEPMELAEHLTYLEYRS 457

  Fly   845 YKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMM 909
            :..:...:.  ..:......|.:|.|.:.:....:|::|::..|.......:|..::...:.|..
Human   458 FCKILFQDY--HSFVTHGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAE 520

  Fly   910 VMLELNNFNGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECREL--SDDHLKKYQERLRSIN 972
            .:|:|.|||.::::|..:..:|:.||:.|...:.....|..|...||  :..:...|:.||.:
Human   521 KLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAA-- 583

  Fly   973 PPCV----PFFGRYLTNILHLEEGNPDLL--ANTELINFSKRRKVAEIIGEIQQYQN-QPYCLNE 1030
              ||    |..|.:|.:::.|:...||.|  |.|.| |.:|.:::..|:.|:....: :|.....
Human   584 --CVGFRFPILGVHLKDLVALQLALPDWLDPARTRL-NGAKMKQLFSILEELAMVTSLRPPVQAN 645

  Fly  1031 ESTIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQ 1095
            ...:......||.:      |..|.||..||:.|||. |:.|..|...      :|..:|....:
Human   646 PDLLSLLTVSLDQY------QTEDELYQLSLQREPRS-KSSPTSPTSC------TPPPRPPVLEE 697

  Fly  1096 TNSSSK 1101
            ..|::|
Human   698 WTSAAK 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	14/75 (19%)
		RasGEF	825..1062	CDD:238087	58/245 (24%)
RASGRP2	XP_016872571.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810