| Sequence 1: | NP_476597.2 | Gene: | Sos / 34790 | FlyBaseID: | FBgn0001965 | Length: | 1596 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_005730.2 | Gene: | RASGRP1 / 10125 | HGNCID: | 9878 | Length: | 797 | Species: | Homo sapiens |
| Alignment Length: | 496 | Identity: | 105/496 - (21%) |
|---|---|---|---|
| Similarity: | 187/496 - (37%) | Gaps: | 120/496 - (24%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 640 MIKGATLCKLIERLTYHIYADPTFVRT------FLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQ 698
Fly 699 DTGTAGAGGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLE 763
Fly 764 KLLNFLEHVNGK--------------SMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEH 814
Fly 815 HLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSE----LVGSPWTKKDKEVK-SPNLLKIM 874
Fly 875 KHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWTF 939
Fly 940 QGLPERYRKFLEECREL------SDDHLKKYQERLRSINPPC----VPFFGRYLTNILHLEEGNP 994
Fly 995 DLLANTELINFSKRRKVAEIIGEIQQYQN--QPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLY 1057
Fly 1058 NESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQTNS 1098 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Sos | NP_476597.2 | Histone | 90..216 | CDD:278551 | |
| H2A | 155..>196 | CDD:305064 | |||
| RhoGEF | 249..432 | CDD:238091 | |||
| PH_SOS | 476..586 | CDD:269963 | |||
| PH | 482..587 | CDD:278594 | |||
| RasGEFN | 637..791 | CDD:214571 | 32/170 (19%) | ||
| RasGEF | 825..1062 | CDD:238087 | 59/253 (23%) | ||
| RASGRP1 | NP_005730.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..23 | ||
| RasGEFN | 54..175 | CDD:214571 | 28/155 (18%) | ||
| Ras exchanger motif region, required for transforming activity. /evidence=ECO:0000250 | 57..110 | 16/61 (26%) | |||
| RasGEF | 201..437 | CDD:214539 | 62/278 (22%) | ||
| EF-hand_7 | 478..527 | CDD:372618 | |||
| C1_1 | 542..591 | CDD:365894 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 673..694 | ||||
| Suppress the PT region-mediated translocation to plasma membrane. /evidence=ECO:0000250 | 686..694 | ||||
| PT region, mediates the BCR-dependent translocation to plasma membrane. /evidence=ECO:0000250 | 718..797 | ||||
| bZIP | <734..780 | CDD:389750 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3417 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.810 | |||||