Protein Alignment Sos and rgl3a

DIOPT Version :10

• Sequence 1: NP_476597.2
• Gene: Sos / 34790
• FlyBaseID: FBgn0001965
• Length: 1596
• Species: Drosophila melanogaster
• Sequence 2: XP_073809706.1
• Gene: rgl3a / 100149956
• ZFINID: ZDB-GENE-101130-1
• Length: 785
• Species: Danio rerio
• Alignment Length: 725
• Identity: 163/725 - (22%)
• Similarity: 281/725 - (38%)
• Gaps: 197/725 - (27%)

  Fly   592 LDRHLDSILQ----DIE---------RKHPLRMPSPEIYKFAVPDSGDN---IVLEERESAGVPM 640
            |..|.:..:|    ::|         .:.|::.|         ||:.::   ....:..:..|..
Zfish    51 LQEHTEDPVQEWGEEVEDGAIYGVTLHREPIQPP---------PDATESDAAFGFMQYRTLKVRR 106

  Fly   641 IKGATLCKLIERLTYHIYADPTFVRTFLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQDTGTAGA 705
            :|.|||.:|:..|......||.::..||:|||.|.....|::||.:
Zfish   107 LKAATLDRLVTELVNPECPDPDYMHIFLSTYRAFTCTNALIELLFQ------------------- 152

  Fly   706 GGMGGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDP--MLLEKLLNF 768
                            |||........| .|:..:..::|.|:|....|....|  ..|..|...
Zfish   153 ----------------REDMVTNLNNSV-CVKSSLPRLIRLWLDEFHEDLRDSPDHQALRLLCVH 200

  Fly   769 LEH-VNGKSMRKWVDSVLKIVQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEI----TLLTL 828
            |.| :..:.:....|::|:..|.:::|..::.: |.|...:.|..|.:|.  ..|:    .:|..
Zfish   201 LRHRLCCRRLVNQADALLRKFQTEDKQICTSAE-VSASAVENPATEDNLD--GQEVQEIGDVLDF 262

  Fly   829 HPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSPNLLKIMKHT----TNVTRWIEKSI- 888
            ...::|.|||:|:.|::..|.|...:|..|:::||: ::.||:..::.|    ..||..:..|:
Zfish   263 PAQDIAEQLTILDAELFSKVVPFHCLGCIWSQRDKK-ENQNLVSTVRATIAQFNVVTNCVITSLL 326

  Fly   889 --------------TEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVYRLRWT- 938
                          ..:..|  |..|:::.|.|.....:|.||:.:.:|::|:.:.:||||:.|
Zfish   327 CPPATSPPGSPPCHRSSPTY--RAKIIEKWISVAQECHQLRNFSSLRAILSALQSNAVYRLKKTW 389

  Fly   939 ----------FQGLPERY---------RKFL-EECRELSDDHLKKYQ-ERLRSINPPC------- 975
                      |:.|.:.:         |:.| ||..:.:|  ::.|. .:...::|.|
Zfish   390 AVISRESMAVFEHLCDTFPDENCVLINREILVEEGNQAAD--VETYSAPKSPRLSPTCKHMQSSS 452

  Fly   976 ---VPFFGRYLTNILHLEEGNPDLLANTE--LINFSKRRKVAEIIGEIQQYQNQ--PYCLNEEST 1033
               ||:.|.|||.:..|:....|   |.|  ||||.||||..||:..|:|.|..  .|.|.....
Zfish   453 SGEVPYLGTYLTVLTMLDTALTD---NVEGGLINFEKRRKEFEILSLIRQLQASCAHYTLQSHPR 514

  Fly  1034 IRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQTNS 1098
            |   ...::....|||::.    |..|..:|| .....|..|..|.|                ..
Zfish   515 I---ISWINSSMSLSDQKS----YELSRELEP-PVDPCPSSPNSWSH----------------RL 555

  Fly  1099 SSKLSNSTSSVAAAAAASSTATSIATASAPSLHASSIMDAPTAAAANAGSGTLAGEQSPQHNPHA 1163
            .:|..|...|.....:..:.|..|:.:|:.|  :.|.|:       :.|...    .||..:|..
Zfish   556 IAKKLNLLLSATENFSRKTLADQISVSSSGS--SGSDME-------DLGRDL----SSPNLSPLV 607

  Fly  1164 FSVFAPV-----IIPERNTSSWSGTPQHTRTDQNNGEVSVPAPHLPKKPGAHVWANNNSTLASAS 1223
            :.|::|.     |..:..|||.:..|...|:.|.:         ||:.|        :||.:|:|
Zfish   608 YKVWSPSVSCQDISVDTPTSSPTPPPSCQRSLQAD---------LPESP--------SSTSSSSS 655

  Fly  1224 AMDVVFSPAL 1233
            :.    ||:|
Zfish   656 SS----SPSL 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	HFD_SOS1_rpt1	68..145	CDD:467039
		HFD_SOS1_rpt2	153..227	CDD:467040
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		RasGEFN	637..791	CDD:214571	35/156 (22%)
		RasGEF	825..1062	CDD:238087	75/291 (26%)
		PHA03247	<1197..1502	CDD:223021	10/37 (27%)
rgl3a	XP_073809706.1	None