DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sos and ralgps1

DIOPT Version :9

Sequence 1:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster
Sequence 2:	NP_001093616.1	Gene:	ralgps1 / 100101642	ZFINID:	ZDB-GENE-070720-16	Length:	581	Species:	Danio rerio

Alignment Length:	492	Identity:	110/492 - (22%)
Similarity:	203/492 - (41%)	Gaps:	107/492 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   788 VQRKNEQEKSNKKIVYAYGHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSE 852
            :..:|.|:.|:.:.:     |...::...|.......:|.:.|.|.|.|:||::..::|.::|.|
Zfish    13 ITSRNTQDSSSSESL-----DGRSLDSAKSFDAVVFDMLKVTPEEFASQITLMDAPVFKAIQPEE 72

  Fly   853 LVGSPWTKKDKEVKSPNLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNF 917
            |....|.||:|...|||::...:....|:.|..:.|..|:..:.|..|:...|::...:|||||.
Zfish    73 LASCGWNKKEKHSLSPNVVAFTRRFNQVSFWAVREILTAQTLKIRAEILGHFIKIAKKLLELNNL 137

  Fly   918 NGILSIVAAMGTASVYRLRWTFQGLPERYRKFLEECRELS--DDHLKKYQERLRSIN-PPCVPFF 979
            :.::|:|:|:.:|.::||..|:..:..:.:...|:...|:  :::..:.:|..||:. .||:|:.
Zfish   138 HSLVSVVSALQSAPIFRLSKTWALISRKDKATFEKLDFLTSKEENYNRMREYTRSLKMAPCIPYL 202

  Fly   980 GRYLTNILHLEEGNP--DLLANTELINFSKRRKVAEIIGEIQ---QYQN-------QPYCLNEES 1032
            |.||.::.:::...|  |.:..||. ..::...:..||.::|   :|.:       |.|.::.
Zfish   203 GIYLFDMTYIDSAYPASDSIIETEQ-RTNQMNNLLRIISDLQVSCKYDHLITLPHVQKYLMSV-- 264

  Fly  1033 TIRQFFEQLDPFNGLSDKQMSDYLYNESLRIEPRGCKTVPKFPRKWPHIPLKSPGIKPRRQNQTN 1097
               ::.|:|..|       :.|..|:.||:|||                              .|
Zfish   265 ---RYIEELQKF-------VEDDNYSLSLKIEP------------------------------GN 289

  Fly  1098 SSSKLSNSTSSVAAAAAASSTA----------TSIAT---ASAPSLHASS------------IMD 1137
            ||.:|.:|...:...:..|.:.          ||:..   ...|:.|..|            :::
Zfish   290 SSPRLVSSKEDLGGPSEVSMSVRYNRRPTCPDTSVVAHLPTPPPARHRKSHSLGNNMMCQFGVVE 354

  Fly  1138 APTAA------AANAGSGTLAGEQSPQHNPHAFSVFAPVIIPERNTSSW----SGTPQHTRTDQN 1192
            :.:|.      |.:....:.....||..|....|||...|......||:    |.|.:..|....
Zfish   355 SKSATFPEKEKARHLLDDSFLESHSPVRNHTHDSVFTNGISLGSRESSFSDELSSTVERGRMYAT 419

  Fly  1193 NG-EVSVPAPHLPKK-------PGAHVWANNNSTLAS 1221
            .| ...||..:.|:.       ||| |.:...|||:|
Zfish   420 LGPNWRVPMCNSPRSRSYIYSTPGA-VSSYECSTLSS 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sos	NP_476597.2	Histone	90..216	CDD:278551
		H2A	155..>196	CDD:305064
		RhoGEF	249..432	CDD:238091
		PH_SOS	476..586	CDD:269963
		PH	482..587	CDD:278594
		RasGEFN	637..791	CDD:214571	0/2 (0%)
		RasGEF	825..1062	CDD:238087	64/251 (25%)
ralgps1	NP_001093616.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		4/22 (18%)
		RasGEF	46..289	CDD:214539	68/285 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..339		4/18 (22%)
		PXXP	329..332		0/2 (0%)
		PH	456..567	CDD:278594	110/492 (22%)
		PH_RalGPS1_2	457..572	CDD:270120
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810