DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adat1 and Adat1

DIOPT Version :9

Sequence 1:	NP_001260450.1	Gene:	Adat1 / 34787	FlyBaseID:	FBgn0028658	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_038953.1	Gene:	Adat1 / 30947	MGIID:	1353631	Length:	499	Species:	Mus musculus

Alignment Length:	511	Identity:	168/511 - (32%)
Similarity:	234/511 - (45%)	Gaps:	145/511 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TVKEIAELCLKKFE-SLPKTGKPTAN-QWTILAGIVEFNRN-TEAC-----------QLVSLGCG 58
            |..|||:||...:. .|||.|||..| :||:||.:|:...: .:||           ::||:|.|
Mouse     3 TADEIAQLCYAHYNVRLPKQGKPEPNREWTLLAAVVKIQASANQACDIPEKEVQVTKEVVSMGTG 67

  Fly    59 TKCIGESKLCPNGLILNDSHAEVLARRGFLRFLYQE------LKQDRIFHWNSTLSTYDMDEHVE 117
            |||||:||:..:|.||||||||::|||.|.|:|..:      ||:|.||...:....:.:...:.
Mouse    68 TKCIGQSKMRESGDILNDSHAEIIARRSFQRYLLHQLHLAAVLKEDSIFVPGTQRGLWRLRPDLS 132

  Fly   118 FHFLSTQTPCGDACILE----EEQPAAR---------------------------------AKRQ 145
            |.|.|:.||||||.|:.    ||||...                                 ||:.
Mouse   133 FVFFSSHTPCGDASIIPMLEFEEQPCCPVIRSWANNSPVQETENLEDSKDKRNCEDPASPVAKKM 197

  Fly   146 RLD-------------------------EDSEM--------------------VY-TGAKLISDL 164
            ||.                         ..|::                    || ||||.:...
Mouse   198 RLGTPARSLSNCVAHHGTQESGPVKPDVSSSDLTKEEPDAANGIASGSFRVVDVYRTGAKCVPGE 262

  Fly   165 SDDPMLQTPGA-------LRTKPGRGERTLSMSCSDKIARWNVIGVQGALLDVLISKPIYFSSLN 222
            :.|  |:.|||       ||.|||||:||.|||||||:|||||:|.|||||...:.||||.|::.
Mouse   263 TGD--LREPGAAYHQVGLLRVKPGRGDRTCSMSCSDKMARWNVLGCQGALLMHFLEKPIYLSAVV 325

  Fly   223 F-CCDDAQLESLERAIFKRFDCRTFKHTRFQPQRPQINIDPGIRFEFS------QRSDWQPSPNG 280
            . .|..:| |::.||:..|.:........|..|..:|. ..|:.||.|      :|.|   ||..
Mouse   326 IGKCPYSQ-EAMRRALTGRCEETLVLPRGFGVQELEIQ-QSGLLFEQSRCAVHRKRGD---SPGR 385

  Fly   281 LI-------WSQVPEELRPYEISVNGKRQGVTKKKMKTSQAALAISKYKLFLTFLELVKFNPKLS 338
            |:       ||.||::  |.:::.||..||.|||::.:.:|...|||.:||.:|.:|      ||
Mouse   386 LVPCGAAISWSAVPQQ--PLDVTANGFPQGTTKKEIGSPRARSRISKVELFRSFQKL------LS 442

  Fly   339 EMFDQQLSDPERI-----AYASCKDLARDYQFAWREIKE-KYFLQWTKKPHELLDF 388
            .:.|.:..|..|:     .|...||.|..||.||..::. :.|..|.:.|.:...|
Mouse   443 SIADDEQPDSIRVTKKLDTYQEYKDAASAYQEAWGALRRIQPFASWIRNPPDYHQF 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adat1	NP_001260450.1	ADEAMc	7..389	CDD:214718	168/511 (33%)
Adat1	NP_038953.1	A_deamin	63..492	CDD:280326	137/437 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..194		19/30 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..237		8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2777
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8096
Inparanoid	1	1.050	122	1.000	Inparanoid score	I4743
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55713
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	1	1.000	-	-		FOG0004810
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103859
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2305
SonicParanoid	1	1.000	-	-		X4484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.770