DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adat1 and ADAT1

DIOPT Version :9

Sequence 1:	NP_001260450.1	Gene:	Adat1 / 34787	FlyBaseID:	FBgn0028658	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001311374.1	Gene:	ADAT1 / 23536	HGNCID:	228	Length:	502	Species:	Homo sapiens

Alignment Length:	514	Identity:	166/514 - (32%)
Similarity:	233/514 - (45%)	Gaps:	148/514 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TVKEIAELCLKKFE-SLPKTGKPTAN-QWTILAGIVEFNRNTE-AC-----------QLVSLGCG 58
            |..|||:||.:.:. .|||.|||..| :||:||.:|:.....: ||           ::||:|.|
Human     3 TADEIAQLCYEHYGIRLPKKGKPEPNHEWTLLAAVVKIQSPADKACDTPDKPVQVTKEVVSMGTG 67

  Fly    59 TKCIGESKLCPNGLILNDSHAEVLARRGFLRFLYQE------LKQDRIFHWNSTLSTYDMDEHVE 117
            |||||:||:..||.|||||||||:|||.|.|:|..:      ||:|.||...:....:.:...:.
Human    68 TKCIGQSKMRKNGDILNDSHAEVIARRSFQRYLLHQLQLAATLKEDSIFVPGTQKGVWKLRRDLI 132

  Fly   118 FHFLSTQTPCGDACILE----EEQP---------------------AARAKRQRLDEDSEM---- 153
            |.|.|:.||||||.|:.    |:||                     |...:|:..|.||.:
Human   133 FVFFSSHTPCGDASIIPMLEFEDQPCCPVFRNWAHNSSVEASSNLEAPGNERKCEDPDSPVTKKM 197

  Fly   154 ----------------------------------------------------------VY-TGAK 159
                                                                      || ||||
Human   198 RLEPGTAAREVTNGAAHHQSFGKQKSGPISPGIHSCDLTVEGLATVTRIAPGSAKVIDVYRTGAK 262

  Fly   160 LISDLSDDPMLQTPGA-------LRTKPGRGERTLSMSCSDKIARWNVIGVQGALLDVLISKPIY 217
            .:...:.|.  ..|||       ||.|||||:||.|||||||:|||||:|.|||||..|:.:|||
Human   263 CVPGEAGDS--GKPGAAFHQVGLLRVKPGRGDRTRSMSCSDKMARWNVLGCQGALLMHLLEEPIY 325

  Fly   218 FSSLNF-CCDDAQLESLERAIFKRFDCRTFKHTRFQPQRPQINIDPGIRFEFS------QRSDWQ 275
            .|::.. .|..:| |:::||:..|....:.....|..|..:| :...:.||.|      :|:|
Human   326 LSAVVIGKCPYSQ-EAMQRALIGRCQNVSALPKGFGVQELKI-LQSDLLFEQSRSAVQAKRAD-- 386

  Fly   276 PSPNGLI-------WSQVPEELRPYEISVNGKRQGVTKKKMKTSQAALAISKYKLFLTFLELVKF 333
             ||..|:       ||.|||:  |.:::.||..||.|||.:.:.||...|||.:||.:|.:|
Human   387 -SPGRLVPCGAAISWSAVPEQ--PLDVTANGFPQGTTKKTIGSLQARSQISKVELFRSFQKL--- 445

  Fly   334 NPKLSEMFDQQLSDPERI----AYASCKDLARDYQFAWREIKEKYFLQWTKKPHELLDF 388
               ||.:...:.....|:    .|...|:.|..||.||..::::.|..|.:.|.:...|
Human   446 ---LSRIARDKWPHSLRVQKLDTYQEYKEAASSYQEAWSTLRKQVFGSWIRNPPDYHQF 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adat1	NP_001260450.1	ADEAMc	7..389	CDD:214718	166/514 (32%)
ADAT1	NP_001311374.1	A_deamin	63..495	CDD:307992	143/446 (32%)
ADAT1	NP_001311374.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..194		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2777
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8096
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55713
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	1	1.000	-	-		FOG0004810
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103859
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4484
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.690