DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adat1 and ADAD1

DIOPT Version :9

Sequence 1:	NP_001260450.1	Gene:	Adat1 / 34787	FlyBaseID:	FBgn0028658	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_640336.1	Gene:	ADAD1 / 132612	HGNCID:	30713	Length:	576	Species:	Homo sapiens

Alignment Length:	376	Identity:	105/376 - (27%)
Similarity:	157/376 - (41%)	Gaps:	83/376 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 QLVSLGCGTKCIGESKLCPNGLILNDSHAEVLARRGFLRFLYQEL----------KQDRIFHWNS 105
            ::|::|.|.....:. :.|:|.:|:|:||.|.|||..||:.|::|          .:..||....
Human   246 EVVAIGTGEYNYSQD-IKPDGRVLHDTHAVVTARRSLLRYFYRQLLLFYSKNPAMMEKSIFCTEP 309

  Fly   106 TLSTYDMDEHVEFHFLSTQTPCGDACILEEEQPAARAKRQ-RLDEDSEMVYTGAKLISDLSDDPM 169
            |.:...:.:::.......|.|.|          :|:.|.| ||:..|         ||....:..
Human   310 TSNLLTLKQNINICLYMNQLPKG----------SAQIKSQLRLNPHS---------ISAFEANEE 355

  Fly   170 LQTPGALRTK-------PGRG-ERTLSMSCSDKIARWNVIGVQGALLDVLISKPIYFSSL---NF 223
            |....|:..|       |..| .|..|||.|||:.||.|:|||||||...| :|:|.||:   :.
Human   356 LCLHVAVEGKIYLTVYCPKDGVNRISSMSSSDKLTRWEVLGVQGALLSHFI-QPVYISSILIGDG 419

  Fly   224 CCDDAQLESLERAIFKRF-DCRTFKHTRFQ-PQRPQINIDP-------GIRFEFSQRSDWQPSPN 279
            .|.|.:  .||.||.:|. |..|.|...|. ..||.|::.|       .:.::|.
Human   420 NCSDTR--GLEIAIKQRVDDALTSKLPMFYLVNRPHISLVPSAYPLQMNLEYKFL---------- 472

  Fly   280 GLIWSQVPEELRPYEISVNGKRQGVTKKKMKTSQAALAISKYKLFLTFLELVKFNPKLSEMFDQQ 344
            .|.|:|....|   || |:|....:|:.....|..::|....|..:    |.:||....|...:.
Human   473 SLNWAQGDVSL---EI-VDGLSGKITESSPFKSGMSMASRLCKAAM----LSRFNLLAKEAKKEL 529

  Fly   345 LSDPERIAYASCKDLARDYQFAWREIKEKYFLQ------WTKKPHELLDFN 389
            |   |...|.:.|.::..||.|  :.|.|.:||      |..|...:..||
Human   530 L---EAGTYHAAKCMSASYQEA--KCKLKSYLQQHGYGSWIVKSPCIEQFN 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adat1	NP_001260450.1	ADEAMc	7..389	CDD:214718	103/374 (28%)
ADAD1	NP_640336.1	DSRM	97..162	CDD:214634
ADAD1	NP_640336.1	A_deamin	249..568	CDD:307992	101/364 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820