DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adat1 and Adarb2

DIOPT Version :9

Sequence 1:	NP_001260450.1	Gene:	Adat1 / 34787	FlyBaseID:	FBgn0028658	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_579836.1	Gene:	Adarb2 / 117088	RGDID:	621519	Length:	746	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	108/408 - (26%)
Similarity:	170/408 - (41%)	Gaps:	76/408 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IAELCLKKFESLPKTGKPTANQWTILAGIV-EFNRNTEACQLVSLGCGTKCIGESKLCPNGLILN 75
            :::|..:||..|.........:...||||| ....:|:..|::.|..|||||....:...||::|
  Rat   372 VSQLVTQKFRELTVGLTSVYARHKTLAGIVMTKGLDTKQAQVIVLSSGTKCISGEHISDQGLVVN 436

  Fly    76 DSHAEVLARRGFLRFLYQELK---------QDRIFHWNSTLSTYDMDEHVEFHFLSTQTPCGDAC 131
            |.|||::|||.||.|||.:|:         .:|..........|.:.|::.||...:.:|||||.
  Rat   437 DCHAEIVARRAFLHFLYTQLELHLSKHQEDPERSIFIRVKEGGYRLRENILFHLYVSTSPCGDAR 501

  Fly   132 I---------LEEEQPAARAKRQRLDEDSEMVYTGAKLISDLSDDPMLQTPGALRTKPG--RGER 185
            :         |...:...|..|..|         ..|:.|.....| ::.|.|::|..|  .||:
  Rat   502 LNSPYEITIDLNSSKHIVRKFRGHL---------RTKIESGEGTVP-VRGPSAVQTWDGILLGEQ 556

  Fly   186 TLSMSCSDKIARWNVIGVQGALLDVLISKPIYFSSLNFCCDDAQLE---SLERAIFKRFDCRTFK 247
            .::|||:||||.|||:|:|||||...| :|:|..|:..    ..|.   .|.|.:..|.:.....
  Rat   557 LVTMSCTDKIASWNVLGLQGALLCHFI-EPVYLHSIIV----GSLHHTGHLARVMSHRMEGIGQL 616

  Fly   248 HTRFQPQRPQINIDPGIRFEFSQRSDWQP--SPNGLIWSQVPEELRPYEISVNGKRQ-GVTKKKM 309
            ...::..||.::   |:....:::....|  |.|.::.|...|.:.    :..|||. |.:.:..
  Rat   617 PASYRQNRPLLS---GVSNAEARQPGKSPHFSANWVVGSADLEIIN----ATTGKRSCGGSSRLC 674

  Fly   310 KTSQAALAISKYKLFLTFLELVKFNPKLSEMFDQQLSDPERIAYASCKDLARDYQFAWREIKEKY 374
            |...:|             ...:.:.:||.........|.  .|...|..|..||    .:|::.
  Rat   675 KHVFSA-------------RWARLHGRLSTRIPGHGDTPS--MYCEAKRGAHTYQ----SVKQQL 720

  Fly   375 FL--------QWTKKPHE 384
            |.        .|.:||.|
  Rat   721 FKAFQKAGLGTWVRKPPE 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adat1	NP_001260450.1	ADEAMc	7..389	CDD:214718	108/408 (26%)
Adarb2	NP_579836.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		R-domain (ssRNA-binding). /evidence=ECO:0000250	23..35
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..105
		DSRM	126..190	CDD:238007
		DSRM	285..>332	CDD:214634
		ADEAMc	367..743	CDD:214718	108/408 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10910
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020