DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adat1 and Adarb1

DIOPT Version :9

Sequence 1:	NP_001260450.1	Gene:	Adat1 / 34787	FlyBaseID:	FBgn0028658	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	XP_006513125.1	Gene:	Adarb1 / 110532	MGIID:	891999	Length:	775	Species:	Mus musculus

Alignment Length:	446	Identity:	120/446 - (26%)
Similarity:	190/446 - (42%)	Gaps:	103/446 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NKKPTVKE-------------IAELCLKKFESLPKT-GKPTANQWTILAGIV-EFNRNTEACQLV 53
            :::|.:.|             ::.|.|.||..|... ..|.|.: .:|:|:| ....:.:..:::
Mouse   370 SRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARR-KVLSGVVMTTGTDVKDAKVI 433

  Fly    54 SLGCGTKCIGESKLCPNGLILNDSHAEVLARRGFLRFLYQEL------KQDR---IFHWNSTLST 109
            |:..|||||....:...||.|||.|||:::||..|||||.:|      |:|:   ||. .|....
Mouse   434 SVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQ-KSERGG 497

  Fly   110 YDMDEHVEFHFLSTQTPCGDACILEEEQPAARAKRQRLDEDSEMVYTGAKLISDLSDDPMLQTPG 174
            :.:.:.|:||...:.:|||||.|....:|..    :.:..||.      :|.......|..:..|
Mouse   498 FRLKDTVQFHLYISTSPCGDARIFSPHEPVL----EGMTPDSH------QLTEPADRHPNRKARG 552

  Fly   175 ALRTK--------PGR-------------GERTLSMSCSDKIARWNVIGVQGALLDVLISKPIYF 218
            .||||        |.|             |||.|:||||||||||||:|:||:||.:.: :||||
Mouse   553 QLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFV-EPIYF 616

  Fly   219 SSLNFCCDDAQL---ESLERAIFKRFDCRTFKHTRFQPQRPQINIDPGIRFEFSQRSDWQP--SP 278
            ||:..    ..|   :.|.||:::|.       :..:...|...::..:....|.....||  :|
Mouse   617 SSIIL----GSLYHGDHLSRAMYQRI-------SNIEDLPPLYTLNKPLLSGISNAEARQPGKAP 670

  Fly   279 N-GLIWSQVPEELRPYEISVNGKRQGVTKKKMKTSQAALAISKYKLFLTFLEL-VKFNPKLSEMF 341
            | .:.|:.....:.....:......|...:          :.|:.|:..::.: .|..|.|   .
Mouse   671 NFSVNWTVGDATIEVINATTGKDELGRPSR----------LCKHALYCRWMRVHGKVPPHL---L 722

  Fly   342 DQQLSDPERIAYASCKDLARDYQFAWREIKEKYFL--------QWTKKPHELLDFN 389
            ..:::.|  ..|...|..||:||.|    |.:.|.        .|.:||.|...|:
Mouse   723 RTKITKP--TTYHESKLAAREYQAA----KARLFTAFIKAGLGAWVEKPTEQDQFS 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adat1	NP_001260450.1	ADEAMc	7..389	CDD:214718	119/441 (27%)
Adarb1	XP_006513125.1	DSRM_RED1_rpt1	139..210	CDD:380724
		DSRM_RED1_rpt2	296..365	CDD:380727
		ADEAMc	386..772	CDD:214718	117/428 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10910
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2305
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950