DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adat1 and ADARB1

DIOPT Version :9

Sequence 1:	NP_001260450.1	Gene:	Adat1 / 34787	FlyBaseID:	FBgn0028658	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	XP_016883731.1	Gene:	ADARB1 / 104	HGNCID:	226	Length:	790	Species:	Homo sapiens

Alignment Length:	443	Identity:	119/443 - (26%)
Similarity:	183/443 - (41%)	Gaps:	96/443 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IAELCLKKFESLPKT-GKPTANQWTILAGIV-EFNRNTEACQLVSLGCGTKCIGESKLCPNGLIL 74
            ::.|.|.||..|... ..|.|.: .:|||:| ....:.:..:::|:..|||||....:...||.|
Human   376 VSRLVLGKFGDLTDNFSSPHARR-KVLAGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLAL 439

  Fly    75 NDSHAEVLARRGFLRFLYQELK--------QDRIFHWNSTLSTYDMDEHVEFHFLSTQTPCGDAC 131
            ||.|||:::||..|||||.:|:        |.|.....|....:.:.|:|:||...:.:|||||.
Human   440 NDCHAEIISRRSLLRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGDAR 504

  Fly   132 ILEEEQPAARAKRQ--------------------RLDEDSEMVYTGAKLISDLSDDPMLQTPGAL 176
            |....:|.....|.                    .|.:.|...:.||.........|..:..|.|
Human   505 IFSPHEPILEGSRSYTQAGVQWCNHGSLQPRPPGLLSDPSTSTFQGAGTTEPADRHPNRKARGQL 569

  Fly   177 RTK--------PGR-------------GERTLSMSCSDKIARWNVIGVQGALLDVLISKPIYFSS 220
            |||        |.|             |||.|:||||||||||||:|:||:||.:.: :||||||
Human   570 RTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFV-EPIYFSS 633

  Fly   221 LNFCCDDAQL---ESLERAIFKRFDCRTFKHTRFQPQRPQINIDPGIRFEFSQRSDWQP--SPN- 279
            :..    ..|   :.|.||:::|.       :..:...|...::..:....|.....||  :||
Human   634 IIL----GSLYHGDHLSRAMYQRI-------SNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNF 687

  Fly   280 GLIWSQVPEELRPYEISVNGKRQGVTKKKMKTSQAALAISKYKLFLTFLELVKFNPKLSEMFDQQ 344
            .:.|:.....:.....:......|          .|..:.|:.|:..::.:....|  |.:...:
Human   688 SVNWTVGDSAIEVINATTGKDELG----------RASRLCKHALYCRWMRVHGKVP--SHLLRSK 740

  Fly   345 LSDPERIAYASCKDLARDYQFAWREIKEKYFL--------QWTKKPHELLDFN 389
            ::.|.  .|...|..|::||.|    |.:.|.        .|.:||.|...|:
Human   741 ITKPN--VYHESKLAAKEYQAA----KARLFTAFIKAGLGAWVEKPTEQDQFS 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adat1	NP_001260450.1	ADEAMc	7..389	CDD:214718	118/441 (27%)
ADARB1	XP_016883731.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10910
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2305
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950