DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adat1 and ADAR

DIOPT Version :9

Sequence 1:	NP_001260450.1	Gene:	Adat1 / 34787	FlyBaseID:	FBgn0028658	Length:	394	Species:	Drosophila melanogaster
Sequence 2:	NP_001351974.1	Gene:	ADAR / 103	HGNCID:	225	Length:	1235	Species:	Homo sapiens

Alignment Length:	429	Identity:	118/429 - (27%)
Similarity:	178/429 - (41%)	Gaps:	101/429 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EIAELCLKKFESLPKTGKPTANQWTILAGIVEFNRNTEACQLVSLGCGTKCIGESKLCPNGLILN 75
            :||.|..:.|.:|..:.:|:.....|||.|:....:.:...:||||.|.:|:....|...|..:|
Human   852 QIAMLSHRCFNTLTNSFQPSLLGRKILAAIIMKKDSEDMGVVVSLGTGNRCVKGDSLSLKGETVN 916

  Fly    76 DSHAEVLARRGFLRFLYQEL-------KQDRIFHWNSTLSTYDMDEHVEFHFLSTQTPCGDACIL 133
            |.|||:::||||:||||.||       .:|.||..........:.:.|.||...:..||||..:.
Human   917 DCHAEIISRRGFIRFLYSELMKYNSQTAKDSIFEPAKGGEKLQIKKTVSFHLYISTAPCGDGALF 981

  Fly   134 EEEQPAARAKRQRLDEDSEMVYTGAKLISDLSDDPMLQTP--GALRTKPGRGERTL--------- 187
            :      ::...|..|.:|..:.           |:.:.|  |.||||...||.|:
Human   982 D------KSCSDRAMESTESRHY-----------PVFENPKQGKLRTKVENGEGTIPVESSDIVP 1029

  Fly   188 ------------SMSCSDKIARWNVIGVQGALLDVLISKPIYFSS--LNFCCDDAQLESLERAIF 238
                        :|||||||.||||:|:|||||...: :|||..|  |.:......   |.|||.
Human  1030 TWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTHFL-QPIYLKSVTLGYLFSQGH---LTRAIC 1090

  Fly   239 KRFDCRTFKHTRFQPQRPQINIDPGIRFEF--------------SQRSDWQPSPNGLIWSQVPEE 289
                ||.        .|.....:.|:|..|              |:|...:.....:.|....
Human  1091 ----CRV--------TRDGSAFEDGLRHPFIVNHPKVGRVSIYDSKRQSGKTKETSVNWCLAD-- 1141

  Fly   290 LRPYEISV-NGKRQGVTKKKMKTSQAALAISKYKLFLTFLELVKFNPKLSEMFDQQLSDPERIAY 353
              .|::.: :|.|..|...:.:.|:    :||..:||.|.:|..|..:         .|..|::|
Human  1142 --GYDLEILDGTRGTVDGPRNELSR----VSKKNIFLLFKKLCSFRYR---------RDLLRLSY 1191

  Fly   354 ASCKDLARDYQFA----WREIKEKYFLQWTKKPHELLDF 388
            ...|..||||:.|    .:.:|:..:..|..||.|..:|
Human  1192 GEAKKAARDYETAKNYFKKGLKDMGYGNWISKPQEEKNF 1230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adat1	NP_001260450.1	ADEAMc	7..389	CDD:214718	118/429 (28%)
ADAR	NP_001351974.1	z-alpha	144..210	CDD:280459
		z-alpha	304..368	CDD:280459
		DSRM	513..578	CDD:214634
		DSRM	624..689	CDD:214634
		DSRM	736..801	CDD:214634
		ADEAMc	848..1231	CDD:214718	118/429 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2305
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850