DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAH1 and CA8

DIOPT Version :9

Sequence 1:	NP_523561.1	Gene:	CAH1 / 34786	FlyBaseID:	FBgn0027844	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_001308766.1	Gene:	CA8 / 767	HGNCID:	1382	Length:	290	Species:	Homo sapiens

Alignment Length:	270	Identity:	102/270 - (37%)
Similarity:	149/270 - (55%)	Gaps:	21/270 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WGYTEENGPAHWAKEYPQASGHRQSPVDITPSSAKKGSELNVAPLKWKYVPEHTKSLVNPGYCWR 69
            |||.|   ...|...:|.|:|..|||:::....|:....|....|...||......:.|.|:..:
Human    29 WGYEE---GVEWGLVFPDANGEYQSPINLNSREARYDPSLLDVRLSPNYVVCRDCEVTNDGHTIQ 90

  Fly    70 VDVNGADSELTGGPL--GDQIFKLEQFHCHWGCTDSKGSEHTVDGVSYSGELHLVHWNTTKYKSF 132
            | :..:.|.|:||||  |.: |:|.:...|||..:.:||||||:..::..||||:|||:|.:.|.
Human    91 V-ILKSKSVLSGGPLPQGHE-FELYEVRFHWGRENQRGSEHTVNFKAFPMELHLIHWNSTLFGSI 153

  Fly   133 GEAAAAPDGLAVLGVFLKAGNHHAELDKVTSLLQFVLHKGDRVTLPQGC-DPGQLLPD--VHTYW 194
            .||...|.|:|::.:|::.|..|..|..||.:||.:.:||...|:|  | :|..||||  :..||
Human   154 DEAVGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIP--CFNPNTLLPDPLLRDYW 216

  Fly   195 TYEGSLTTPPCSESVIWIVFKTPIEVSDDQLNAMRNLNAY----DVKEECPCNEFNGKVINNFRP 255
            .||||||.|||||.|.||:|:.|:.:|..|:...|.|..:    ::.|.|     :|.:.:||||
Human   217 VYEGSLTIPPCSEGVTWILFRYPLTISQLQIEEFRRLRTHVKGAELVEGC-----DGILGDNFRP 276

  Fly   256 PLPLGKRELR 265
            ..||..|.:|
Human   277 TQPLSDRVIR 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH1	NP_523561.1	Carb_anhydrase	5..263	CDD:215000	100/266 (38%)
CA8	NP_001308766.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
CA8	NP_001308766.1	alpha_CARP_VIII	35..289	CDD:239394	98/261 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820