DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH1 and CA5A

DIOPT Version :9

Sequence 1:	NP_523561.1	Gene:	CAH1 / 34786	FlyBaseID:	FBgn0027844	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	XP_011521611.1	Gene:	CA5A / 763	HGNCID:	1377	Length:	376	Species:	Homo sapiens

Alignment Length:	165	Identity:	67/165 - (40%)
Similarity:	95/165 - (57%)	Gaps:	7/165 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 NGPAH--WAKEYPQASGHRQSPVDITPSSAKKGSELNVAPLKWKYVPEHTKSLVNPGYCWRVDVN 73
            |...|  |........|.||||::|....:....:|.  ||:..|.......:.|.||.::|:.:
Human    45 NNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLK--PLRVSYEAASCLYIWNTGYLFQVEFD 107

  Fly    74 GAD--SELTGGPLGDQIFKLEQFHCHWGCTDSKGSEHTVDGVSYSGELHLVHWNTTKYKSFGEAA 136
            .|.  |.::|||| :..::|:|||.|||..:..||||||||.:|..||||||||:.||:::.||.
Human   108 DATEASGISGGPL-ENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAV 171

  Fly   137 AAPDGLAVLGVFLKAGNHHAELDKVTSLLQFVLHK 171
            ...:||||:|||||.|.||..|.::..:|..:.||
Human   172 VGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHK 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH1	NP_523561.1	Carb_anhydrase	5..263	CDD:215000	67/165 (41%)
CA5A	XP_011521611.1	alpha_CA	61..>212	CDD:294017	64/149 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I2507
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3457
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48615
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	1	1.000	-	-		otm42196
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.080