back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAH1 and CA2

DIOPT Version :9

Sequence 1:	NP_523561.1	Gene:	CAH1 / 34786	FlyBaseID:	FBgn0027844	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_000058.1	Gene:	CA2 / 760	HGNCID:	1373	Length:	260	Species:	Homo sapiens

Alignment Length:	273	Identity:	125/273 - (45%)
Similarity:	158/273 - (57%)	Gaps:	25/273 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHHWGYTEENGPAHWAKEYPQASGHRQSPVDITPSSAKKGSELNVAPLKWKYVPEHTKSLVNPG 65
            |||||||.:.|||.||.|::|.|.|.|||||||...:||....|.  ||...|....:..::|.|
Human     1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLK--PLSVSYDQATSLRILNNG 63

  Fly    66 YCWRVDVNGADSE--LTGGPLGDQIFKLEQFHCHWGCTDSKGSEHTVDGVSYSGELHLVHWNTTK 128
            :.:.|:.:.:..:  |.|||| |..::|.|||.|||..|.:|||||||...|:.|||||||| ||
Human    64 HAFNVEFDDSQDKAVLKGGPL-DGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWN-TK 126

  Fly   129 YKSFGEAAAAPDGLAVLGVFLKAGNHHAELDKVTSLLQFVLHKGDRVTLPQGCDPGQLLPDVHTY 193
            |..||:|...||||||||:|||.|:....|.||..:|..:..||..... ...||..|||:...|
Human   127 YGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADF-TNFDPRGLLPESLDY 190

  Fly   194 WTYEGSLTTPPCSESVIWIVFKTPIEVSDDQLNAMRNLNAYDVKEECPCNEFNGK------VINN 252
            |||.|||||||..|.|.|||.|.||.||.:|:...|.||            |||:      :::|
Human   191 WTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLN------------FNGEGEPEELMVDN 243

  Fly   253 FRPPLPLGKRELR 265
            :||..||..|:::
Human   244 WRPAQPLKNRQIK 256

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.