Protein Alignment CAH1 and CA2

DIOPT Version :10

• Sequence 1: NP_523561.1
• Gene: CAH1 / 34786
• FlyBaseID: FBgn0027844
• Length: 270
• Species: Drosophila melanogaster
• Sequence 2: NP_000058.1
• Gene: CA2 / 760
• HGNCID: 1373
• Length: 260
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 125/273 - (45%)
• Similarity: 158/273 - (57%)
• Gaps: 25/273 - (9%)

  Fly     1 MSHHWGYTEENGPAHWAKEYPQASGHRQSPVDITPSSAKKGSELNVAPLKWKYVPEHTKSLVNPG 65
            |||||||.:.|||.||.|::|.|.|.|||||||...:||....|.  ||...|....:..::|.|
Human     1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLK--PLSVSYDQATSLRILNNG 63

  Fly    66 YCWRVDVNGADSE--LTGGPLGDQIFKLEQFHCHWGCTDSKGSEHTVDGVSYSGELHLVHWNTTK 128
            :.:.|:.:.:..:  |.|||| |..::|.|||.|||..|.:|||||||...|:.|||||||| ||
Human    64 HAFNVEFDDSQDKAVLKGGPL-DGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWN-TK 126

  Fly   129 YKSFGEAAAAPDGLAVLGVFLKAGNHHAELDKVTSLLQFVLHKGDRVTLPQGCDPGQLLPDVHTY 193
            |..||:|...||||||||:|||.|:....|.||..:|..:..||..... ...||..|||:...|
Human   127 YGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADF-TNFDPRGLLPESLDY 190

  Fly   194 WTYEGSLTTPPCSESVIWIVFKTPIEVSDDQLNAMRNLNAYDVKEECPCNEFNGK------VINN 252
            |||.|||||||..|.|.|||.|.||.||.:|:...|.||            |||:      :::|
Human   191 WTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLN------------FNGEGEPEELMVDN 243

  Fly   253 FRPPLPLGKRELR 265
            :||..||..|:::
Human   244 WRPAQPLKNRQIK 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH1	NP_523561.1	Carb_anhydrase	11..265	CDD:459707	118/261 (45%)
CA2	NP_000058.1	alpha_CA_I_II_III_XIII	1..259	CDD:239393	125/273 (46%)