DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH1 and CAH7

DIOPT Version :9

Sequence 1:	NP_523561.1	Gene:	CAH1 / 34786	FlyBaseID:	FBgn0027844	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_001287267.1	Gene:	CAH7 / 41238	FlyBaseID:	FBgn0037788	Length:	304	Species:	Drosophila melanogaster

Alignment Length:	269	Identity:	90/269 - (33%)
Similarity:	136/269 - (50%)	Gaps:	44/269 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SHHWGYTEENGPAHWAKEYPQ-----ASGHRQSPVDITPSSAKKGSELNVAPLKWKYVPEHTKSL 61
            ::.|||.:.:.  :..:.:|:     .||.:|||:::....|.|| |.:.  ||::...||.|:|
  Fly    19 ANEWGYPDLDN--NQDEPFPKWGGLCDSGKKQSPINLHVKGALKG-EFDA--LKFENYDEHQKNL 78

  Fly    62 --VNPGYCWRVDVNGADSELT--GGPLGDQIFKLEQFHCHWGCTDSKGSEHTVDGVSYSGELHLV 122
              ||.|:  .:.::|.|.|||  ||.| .|.|.:||.|.||      .||||::.:.|..|:|:|
  Fly    79 RMVNNGH--SIQLSGFDHELTLSGGAL-LQDFVVEQIHMHW------WSEHTINDIRYPLEVHIV 134

  Fly   123 HWNTTKYKSFGEAAAAPDGLAVLGVFLKAGNHHAELDKVTSLLQFV--LHKGDRVTLP----QGC 181
            |.||. |.:...||...||:.|:||.....|...|  .:.|:::.:  :...|.:..|    ...
  Fly   135 HRNTI-YPNMTMAANFKDGIVVIGVLYHVSNTPNE--AIGSIIKSLGAVKSYDSMNKPVLVADSL 196

  Fly   182 DPGQLLPDVHTYWTYEGSLTTPPCSESVIWIVFKTPIEVSDDQLNAMRNLNAYDVKEECPCNEFN 246
            ....|:|.|..|:||.||||||.|:|:|.|||......|:.||:|..:.:. ||          .
  Fly   197 AVDDLVPSVENYFTYAGSLTTPTCAEAVTWIVLTETFPVTLDQVNEFKEIE-YD----------E 250

  Fly   247 GKVI-NNFR 254
            ||.: ||:|
  Fly   251 GKQLHNNYR 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH1	NP_523561.1	Carb_anhydrase	5..263	CDD:215000	90/266 (34%)
CAH7	NP_001287267.1	alpha_CA	45..269	CDD:238200	85/241 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446818
Domainoid	1	1.000	91	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG3338
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I2251
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113047at6656
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	1	1.000	-	-		mtm1014
orthoMCL	1	0.900	-	-		OOG6_100138
Panther	1	1.100	-	-	P	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
	11	10.800