DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH1 and CAH2

DIOPT Version :9

Sequence 1:	NP_523561.1	Gene:	CAH1 / 34786	FlyBaseID:	FBgn0027844	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_648555.1	Gene:	CAH2 / 39390	FlyBaseID:	FBgn0027843	Length:	335	Species:	Drosophila melanogaster

Alignment Length:	274	Identity:	98/274 - (35%)
Similarity:	147/274 - (53%)	Gaps:	25/274 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHHWGYTEENGPAHWAKEYPQASGHRQSPVDITPSSA--KKGSELNVAPLKWKYVPEHTKSLVN 63
            ::..:||...:||.||:::|.:.||..|||::|...||  ||..:|..  ..:|.||::.: :.|
  Fly    24 LAQDFGYEGRHGPEHWSEDYARCSGKHQSPINIDQVSAVEKKFPKLEF--FNFKVVPDNLQ-MTN 85

  Fly    64 PGYCWRVDVNGADSEL---TGGPLGDQI---FKLEQFHCHWGCTDSKGSEHTVDGVSYSGELHLV 122
            .|:...|.::..:.|:   .||||.::.   ::.||||.|||..|:.|||..::..:|..|||:|
  Fly    86 NGHTVLVKMSYNEDEIPSVRGGPLAEKTPLGYQFEQFHFHWGENDTIGSEDLINNRAYPAELHVV 150

  Fly   123 HWNTTKYKSFGEAAAAPDGLAVLGVFLKAGNHH-AELDKVTSLLQFVLHKGDRVTLPQGCDPGQL 186
            ..| .:|..|..|.....|:||:..|.:.|:.. ...:..|:||..:..||..|.:......|:.
  Fly   151 LRN-LEYPDFASALDKDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDRKGKSVNMTNPLPLGEY 214

  Fly   187 L-PDVHTYWTYEGSLTTPPCSESVIWIVFKTPIEVSDDQLNAMRNLNAYDVKEECPCNEFNGKVI 250
            : ..|.:|::|.||||||||||.|.||.|.|||::::.||||.|.|.|.|           ..:.
  Fly   215 ISKSVESYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAFRLLTAND-----------DHLK 268

  Fly   251 NNFRPPLPLGKREL 264
            |||||..||..|.|
  Fly   269 NNFRPIQPLNDRTL 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH1	NP_523561.1	Carb_anhydrase	5..263	CDD:215000	96/267 (36%)
CAH2	NP_648555.1	Carb_anhydrase	28..281	CDD:215000	96/267 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I2610
eggNOG	1	0.900	-	-		E1_COG3338
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I2251
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113047at6656
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	1	1.000	-	-		mtm1014
orthoMCL	1	0.900	-	-		OOG6_100138
Panther	1	1.100	-	-	P	PTHR18952
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
	10	9.870