DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH1 and Ca12

DIOPT Version :9

Sequence 1:	NP_523561.1	Gene:	CAH1 / 34786	FlyBaseID:	FBgn0027844	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_001074225.1	Gene:	Ca12 / 363085	RGDID:	1306612	Length:	354	Species:	Rattus norvegicus

Alignment Length:	255	Identity:	95/255 - (37%)
Similarity:	145/255 - (56%)	Gaps:	15/255 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WGYTEENGPAHWAKEYPQASGHRQSPVDITPSSAKKGSELNVAPLK---WKYVPEHTKSLVNPGY 66
            |.|....|..:|:|:||...|..|||:|:.....:..:.|  |||:   :....|...:|.|.|:
  Rat    32 WTYIGPAGEKNWSKKYPSCGGLLQSPIDLHSDILQYDASL--APLQFQGYNVSVEKLLNLTNDGH 94

  Fly    67 CWRVDVNGADSELTGGPLGDQIFKLEQFHCHWG-CTDSKGSEHTVDGVSYSGELHLVHWNTTKYK 130
            ..|:::| :|..:.|  |....::.||.|.||| ..|..||||||.|..::.|||:||:|:..|.
  Rat    95 SVRLNLN-SDMYIQG--LQPHQYRAEQLHLHWGNRNDPHGSEHTVSGKHFAAELHIVHYNSDLYS 156

  Fly   131 SFGEAAAAPDGLAVLGVFLKAGNHHAELDKVTSLLQFVLHKGDRVTLPQGCDPGQLLPD-VHTYW 194
            .||.|:...:|||||.|.::.|:.:...||:.|.||.|.:||.:|.:| |.:..:|||: ...|:
  Rat   157 DFGSASDKSEGLAVLAVLIEIGSVNPSYDKIFSHLQHVKYKGQQVLIP-GFNIEELLPESPGEYY 220

  Fly   195 TYEGSLTTPPCSESVIWIVFKTPIEVSDDQLNAMRNLNAYDVKEECPCNEFNGKVINNFR 254
            .||||||||||..:|:|.||:.|:::|.:||.|:.....:...::....|    ::||||
  Rat   221 RYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALETALYFTHMDDPSPRE----MVNNFR 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH1	NP_523561.1	Carb_anhydrase	5..263	CDD:215000	95/255 (37%)
Ca12	NP_001074225.1	alpha_CA	39..290	CDD:294017	93/248 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820