DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH1 and CA14

DIOPT Version :9

Sequence 1:	NP_523561.1	Gene:	CAH1 / 34786	FlyBaseID:	FBgn0027844	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_036245.1	Gene:	CA14 / 23632	HGNCID:	1372	Length:	337	Species:	Homo sapiens

Alignment Length:	263	Identity:	86/263 - (32%)
Similarity:	133/263 - (50%)	Gaps:	15/263 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HWGYTEENGPAHWAKEYPQASGHRQSPVDITPSSAKKGSEL-NVAPLKWKYVPEHTKSLVNPGYC 67
            ||.|...:|..||...||:...:.|||:||...|.....:| .:.|..:.........|.|.|:.
Human    21 HWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHT 85

  Fly    68 WRVDVNGADSELTGGPLGDQIFKLEQFHCHWGCTDSK-GSEHTVDGVSYSGELHLVHWNTTKYKS 131
            .::.:   .|.|..|.| .:.:...|.|.|||...|. ||||.::..:...|||:||:::..|.|
Human    86 VQLSL---PSTLYLGGL-PRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDS 146

  Fly   132 FGEAAAAPDGLAVLGVFLKAG-NHHAELDKVTSLLQFVLHKGDRVTLPQGCDPGQLLP-DVHTYW 194
            ..|||..|.||||||:.::.| ..:...:.:.|.|..|.||..:.::|. .:..:||| .:..|:
Human   147 LSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPP-FNLRELLPKQLGQYF 210

  Fly   195 TYEGSLTTPPCSESVIWIVFKTPIEVSDDQLNAMRNLNAYDVKEECPCNEFNGKVINNFRPPLPL 259
            .|.||||||||.:||:|.||....::|.:||..::. ..:..:|| |    :..::.|:|...||
Human   211 RYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQG-TLFSTEEE-P----SKLLVQNYRALQPL 269

  Fly   260 GKR 262
            .:|
Human   270 NQR 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH1	NP_523561.1	Carb_anhydrase	5..263	CDD:215000	85/262 (32%)
CA14	NP_036245.1	alpha_CA_XII_XIV	29..278	CDD:239400	83/255 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100138
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720