DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH1 and ca6

DIOPT Version :9

Sequence 1:	NP_523561.1	Gene:	CAH1 / 34786	FlyBaseID:	FBgn0027844	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	XP_009295179.1	Gene:	ca6 / 100006448	ZFINID:	ZDB-GENE-030131-7091	Length:	538	Species:	Danio rerio

Alignment Length:	280	Identity:	94/280 - (33%)
Similarity:	136/280 - (48%)	Gaps:	51/280 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HWGYTEENGPAHWAKEYPQASGHRQSPVDITPSSAKKGSELNVAPLKWKYVPEHTKSLVNPGYCW 68
            :|.|:.|....|||::|....|.:|||:||...             |.:|.| ..:.|...||
Zfish    25 YWTYSGELDQKHWAEKYHDCGGQQQSPIDIQRR-------------KVRYSP-RMQQLELTGY-- 73

  Fly    69 RVDVNGADSELTGG-------PLGDQIFK-------LEQFHCHWGCTD--SKGSEHTVDGVSYSG 117
             .|:.|:......|       |...:|.|       ..|.|.|||..|  :.|||||:||:.|..
Zfish    74 -EDIRGSFLMKNNGHSVEIQLPSTMKITKGFPHQYTAVQMHLHWGGWDLEASGSEHTMDGIRYMA 137

  Fly   118 ELHLVHWNTTKYKSFGEAAAAPDGLAVLGVFLKAGNHHAE----LDKVTSLLQFVLHKGDRVTLP 178
            |||:||:|:.||.||.||...|||||||..|.:.|  |.|    .|.:::|.. :.:.|..:::.
Zfish   138 ELHVVHYNSEKYPSFEEAKNKPDGLAVLAFFFEDG--HFENTYYSDFISNLAN-IKYVGQSMSIS 199

  Fly   179 QGCDPGQLLPDVHTYWTYEGSLTTPPCSESVIWIVFKTPIEVSDDQLNAMRN-LNAYDVKEECPC 242
            .......|..::..::.|:||||||||.|||:|.||.|||.:|.:|:..:.: |..:|
Zfish   200 NLNVLSMLSENLSHFYRYKGSLTTPPCFESVMWTVFDTPITLSHNQIRKLESTLMDHD------- 257

  Fly   243 NEFNGKVINNFRPPLPLGKR 262
               |..:.|::|...||.:|
Zfish   258 ---NKTLWNDYRMAQPLNER 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH1	NP_523561.1	Carb_anhydrase	5..263	CDD:215000	94/279 (34%)
ca6	XP_009295179.1	alpha_CA	33..281	CDD:320708	91/272 (33%)
ca6	XP_009295179.1	LamG	332..521	CDD:328935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X57
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820