Protein Alignment Sec71 and GEA2

DIOPT Version :9

• Sequence 1: NP_609675.2
• Gene: Sec71 / 34785
• FlyBaseID: FBgn0028538
• Length: 1653
• Species: Drosophila melanogaster
• Sequence 2: NP_010892.1
• Gene: GEA2 / 856691
• SGDID: S000000748
• Length: 1459
• Species: Saccharomyces cerevisiae
• Alignment Length: 1532
• Identity: 315/1532 - (20%)
• Similarity: 566/1532 - (36%)
• Gaps: 449/1532 - (29%)

  Fly    77 INAETYFLPFEL--ACKSRSPRIVVTALDCLQKLIAYGHLTGSIQDSANPGHLLIDRIVVTIYGC 139
            |::.|...||.|  :..|.|..|...|||.|||......:..|.|:........::.:.    .|
Yeast    92 IDSLTILQPFLLIVSTSSISGYITSLALDSLQKFFTLNIINESSQNYIGAHRATVNALT----HC 152

  Fly   140 -FSGPQ--TDEAVQLQIIKALLTVVTSQHVEIHEFTLLQAVRTCYDIYLSSKNL--------VNQ 193
             |.|.|  :|::|.|:::..|.::|.|.:.::...:::      ||:..:..:|        |.:
Yeast   153 RFEGSQQLSDDSVLLKVVFLLRSIVDSPYGDLLSNSII------YDVLQTILSLACNNRRSEVLR 211

  Fly   194 TTARATLTQMLNVIFARME-------NQVYELPPPNSNPTNGSIHSEDCNGSGEESLRDSDEVIA 251
            ..|::|:..:...||::::       ||:|    .|.......:...|..|:..||..:..:
Yeast   212 NAAQSTMIAVTVKIFSKLKTIEPVNVNQIY----INDESYTNDVLKADTIGTNVESKEEGSQ--- 269

  Fly   252 SELLAEIISAAYNEAMKDQESVGEPEPTLNGNDYSSHSDHDSVE---LHSENDAVVTAKFTHILQ 313
                              ::.:|     :..|:..:.|:.|.:|   :|||. :...|:...|:|
Yeast   270 ------------------EDPIG-----MKVNNEEAISEDDGIEEEHIHSEK-STNGAEQLDIVQ 310

  Fly   314 K--------DAFL-------VFRALCKLSMKPL-PDGHPDPKSHELRSKVLSLHLLLLILQNAG- 361
            |        .|:.       |.|....|.:..: |:   :...|...:::..|.|:...|:.:|
Yeast   311 KTTRSNSRIQAYADDNYGLPVVRQYLNLLLSLIAPE---NELKHSYSTRIFGLELIQTALEISGD 372

  Fly   362 --------------PVFRSNEMFIMAIKQYLCVALSNNGVSLVPEVFELSLSIFVALLSNFKVHL 412
                          |:|:|          .|.:..:...:||:....:|..::.|.|.:|    |
Yeast   373 RLQLYPRLFTLISDPIFKS----------ILFIIQNTTKLSLLQATLQLFTTLVVILGNN----L 423

  Fly   413 KRQIEVFFKEIFLNILE---ANSSSFEH-------KWMVIQALTRICADAQS-VVDIYVNYDCDF 466
            :.|||:....||..:|:   ||:||.|:       |.::|:.::.:...:.| ....::|:||:.
Yeast   424 QLQIELTLTRIFSILLDDGTANNSSSENKNKPSIIKELLIEQISILWTRSPSFFTSTFINFDCNL 488

  Fly   467 SAANLFERLVNDLSKIAQGRQALELGANPMQEKSMRIRGLECLVSILKCMVEWSKDLYVNPNMPV 531
            ..|::....:..|:|:|....||                                    .....|
Yeast   489 DRADVSINFLKALTKLALPESAL------------------------------------TTTESV 517

  Fly   532 PPMQVQSPTSTEQDQADTTIQTMHSGSSHSLNSNQEQL---QDLPEALEERKMRKEVMETGIELF 593
            ||:.::...|...|..|           |..:.::|:.   ::..|.|::|..:.|.:|. ...|
Yeast   518 PPICLEGLVSLVDDMFD-----------HMKDIDREEFGRQKNEMEILKKRDRKTEFIEC-TNAF 570

  Fly   594 NRKPQKGVQFLQEKQLLGATCG-DIARWL-HEDERLDKTVIGNYIGENDDHSKEVMCAYIDAFDF 656
            |.||:||:..|.||..:.:... |||.:| :.:.|::|..||..:...|..|  ::..||..|||
Yeast   571 NEKPKKGIPMLIEKGFIASDSDKDIAEFLFNNNNRMNKKTIGLLLCHPDKVS--LLNEYIRLFDF 633

  Fly   657 RQMEVVAALRFLLEGFRLPGEAQKIDRLMEKFASRYCECNPKNQLFQ-----------------S 704
            ..:.|..|:|.||..||||||:|:|:|::|.|:|.|||    ||.:.                 .
Yeast   634 SGLRVDEAIRILLTKFRLPGESQQIERIIEAFSSAYCE----NQDYDPSKISDNAEDDISTVQPD 694

  Fly   705 ADTVYVLAFSIIMLTTDLHSPQVKHKMTKEQYIKMNRGISDSKSDLPEEYLSSIYDEISEHEIKM 769
            ||:|::|::|||||.||||:||||..|:.|.|....:|..:.| |.|..||..||..|.:.||.|
Yeast   695 ADSVFILSYSIIMLNTDLHNPQVKEHMSFEDYSGNLKGCCNHK-DFPFWYLDRIYCSIRDKEIVM 758

  Fly   770 -KNNSGMLQQAKPTGKQAFITEKRRKLLWNMEMEVISLTA--TNLMQSVSHVKSPFTSAKHLEHV 831
             :.:.|              .||..:..||   .:||.|.  |.:.:....|....|..:.|...
Yeast   759 PEEHHG--------------NEKWFEDAWN---NLISSTTVITEIKKDTQSVMDKLTPLELLNFD 806

  Fly   832 RPMFKMAWTPFLAA-FSVGLQDCDDPEIATLCLDGIRCAIRIACIFHMSLERDAYVQALARF--- 892
            |.:||......::. |::.:...|| .|:|..:              .||::.:|:.|...|
Yeast   807 RAIFKQVGPSIVSTLFNIYVVASDD-HISTRMI--------------TSLDKCSYISAFFDFKDL 856

  Fly   893 ------------TLLNAN------------SPINEMKAKNIDTIKTLIMVAHTDGNYLGSS---- 929
                        ||:|::            .|:..::.|..|| .|.|.|: ||....|.|
Yeast   857 FNDILNSIAKGTTLINSSHDDELSTLAFEYGPMPLVQIKFEDT-NTEIPVS-TDAVRFGRSFKGQ 919

  Fly   930 -----------------------WLDIVKCISQLELAQLIGTGVRPQ------------------ 953
                                   ||:||..|..|....::...:.|.
Yeast   920 LNTVVFFRIIRRNKDPKIFSKELWLNIVNIILTLYEDLILSPDIFPDLQKRLKLSNLPKPSPEIS 984

  Fly   954 ---------FLSGAQTTLKDSLNPSVKEHIGETSSQSVVVAVDRIFTGSMRLDGDAIVDFVKALC 1009
                     .||...:.||....|: :|.|..:......:....|.......:.:...|.:|.|.
Yeast   985 INKSKESKGLLSTFASYLKGDEEPT-EEEIKSSKKAMECIKSSNIAASVFGNESNITADLIKTLL 1048

  Fly  1010 QVSVDELQQQQPRMF--SLQKIVEISYYNMERIRLQWSRIWQVLGEHFNAVGCNSNEEISFFALD 1072
            ..:..|......|.|  .|..|:|::      |.|              .:.|...:|:..|.|.
Yeast  1049 DSAKTEKNADNSRYFEAELLFIIELT------IAL--------------FLFCKEEKELGKFILQ 1093

  Fly  1073 SLRQLS-MKFMEKGEFSNFRFQKDFLRPFEHIMKKNASPAIRDMVVRC------IAQMVNSQAHN 1130
            .:.||| .|.:.|.........|..|                  :..|      :::::|.:.
Yeast  1094 KVFQLSHTKGLTKRTVRRMLTYKILL------------------ISLCADQTEYLSKLINDEL-- 1138

  Fly  1131 IRSGWKNIFSIFHLAAGDNEEPIVELAFQTT------GKIIGDLYKRQFAIMVDSFQDAVKCLSE 1189
            ::.|  :||:....|....:|.:..| |..|      |.::|:....:|...|.:.::..:.:.|
Yeast  1139 LKKG--DIFTQKFFATNQGKEFLKRL-FSLTESEFYRGFLLGNENFWKFLRKVTAMKEQSESIFE 1200

  Fly  1190 FATARFPDTSMEAIRLVRTCAQCVHEAPQLFAEHAGMENDASV-AEEDRVWVRGWFPMLFSLSCV 1253
            :..        |:|:                       .|::: ..|:.:||.|....:.|:..|
Yeast  1201 YLN--------ESIK-----------------------TDSNILTNENFMWVLGLLDEISSMGAV 1234

  Fly  1254 VNRCKLDVRTRALTVLFEIVKTYGESFKPHWWKDLFNVIFRIFDNMKLPEHVTEK---------- 1308
            .|..:::.:        ::.::..:..|.:.:|....:..:   :::|..|:.|.
Yeast  1235 GNHWEIEYK--------KLTESGHKIDKENPYKKSIELSLK---SIQLTSHLLEDNNDLRKNEIF 1288

  Fly  1309 -----------------SEWMTTTCNHALYAIIDVFTQYFDVLGHLLLEELFAQLHWCVQQSNEQ 1356
                             ||:...|....|...|::.|...:.:..|:...|...|:....|.:::
Yeast  1289 AIIQALAHQCINPCKQISEFAVVTLEQTLINKIEIPTNEMESVEELIEGGLLPLLNSSETQEDQK 1353

  Fly  1357 LARSGTNCLENLVISNGFKFNESTWDKTCQCILDIFN 1393
            :..|....:.:.|..:..|..: |.::|...||.|||
Yeast  1354 ILISSILTIISNVYLHYLKLGK-TSNETFLKILSIFN 1389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec71	NP_609675.2	PLN03076	13..1580	CDD:215560	315/1532 (21%)
		DCB	30..212	CDD:292830	34/147 (23%)
		Sec7_N	312..465	CDD:289549	39/194 (20%)
		Sec7	582..767	CDD:279680	77/203 (38%)
		DUF1981	1080..1161	CDD:286414	13/86 (15%)
GEA2	NP_010892.1	COG5307	298..1331	CDD:227623	251/1225 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344272
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5307
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740